Scientists develop pill able to kill all solid tumors in preclinical research(cityofhope.org)
cityofhope.org
Scientists develop pill able to kill all solid tumors in preclinical research
https://www.cityofhope.org/city-hope-scientists-develop-targeted-chemotherapy-able-kill-all-solid-tumors-preclinical-research
25 comments
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The Cell Chemical Biology study entitled “Small Molecule Targeting of Transcription-Replication Conflict for Selective Chemotherapy” was supported by the Department of Defense
Congress directs the military to fund research for a variety of medical conditions that impact both currently serving and retired military personnel: https://cdmrp.health.mil/researchprograms
Seems bizarre though, no? Why not do this through the NIH or similar group with the deep expertise in this field?
Because the US military has a 243 year history of providing benefits for its war wounded and disabled.
As for "deep expertise" - my father worked for NIH, the VA and a few universities doing basic medical research for about three decades. Usually multiple of those at the same time, sometimes on the same project.
As for "deep expertise" - my father worked for NIH, the VA and a few universities doing basic medical research for about three decades. Usually multiple of those at the same time, sometimes on the same project.
Providing benefits and developing new treatments seem to differ though, don’t they?
Regarding your father, what was the benefit to him as a researcher to have all of these different groups to work for? Seems like there would be more waste (more fixed overhead of administrators) and bureaucracy.
Regarding your father, what was the benefit to him as a researcher to have all of these different groups to work for? Seems like there would be more waste (more fixed overhead of administrators) and bureaucracy.
> Providing benefits and developing new treatments seem to differ though, don’t they?
Not at all- many of the health conditions experienced by veterans are service-related, and no private funding is going to fund the basic research. Some of the research is also related to actively serving soldiers. During the Iraq and Afghanistan wars, some of my dad's research was related to keeping soldiers fighting in desert climates hydrated. I also did some work in a VA lab in high school which was researching new prosthetics technologies for victims of IED bombings, which did not leave enough of the persons's limb remaining for existing prosthetic designs to attach to.
> Regarding your father, what was the benefit to him as a researcher to have all of these different groups to work for?
More opportunities for funding! Federal grants are very competitive.
> Seems like there would be more waste (more fixed overhead of administrators) and bureaucracy.
Standard operating procedure when the US government's money is involved.
Not at all- many of the health conditions experienced by veterans are service-related, and no private funding is going to fund the basic research. Some of the research is also related to actively serving soldiers. During the Iraq and Afghanistan wars, some of my dad's research was related to keeping soldiers fighting in desert climates hydrated. I also did some work in a VA lab in high school which was researching new prosthetics technologies for victims of IED bombings, which did not leave enough of the persons's limb remaining for existing prosthetic designs to attach to.
> Regarding your father, what was the benefit to him as a researcher to have all of these different groups to work for?
More opportunities for funding! Federal grants are very competitive.
> Seems like there would be more waste (more fixed overhead of administrators) and bureaucracy.
Standard operating procedure when the US government's money is involved.
You gotta get creative when you have a trillion to dispense of every year.
This is the "Congressionally Directed Medical Research Programs".
Directed by congress, run by DoD, doing cancer researches.
Directed by congress, run by DoD, doing cancer researches.
Googling "was supported by the Department of Defense" give many interesting results.
This is a good point. Few people are brave enough to search for sentence fragments when they read articles online
DoD funds the VA, and cancer is a vast concern and expense for them. Good use of funds IMO.
I wish the best and fastest possible success to this very promising research. I wish it would come sooner for my family.
I wish the best and fastest possible success to this very promising research. I wish it would come sooner for my family.
You would be surprised. The DoD supports a really wide range of research, from biomedical to materials, energy, and computer science. After all, everything can be used to "defend" against an adversary.
It is one of the things that the US is still doing right. Lots of money is poured into basic research. Not all of them are used to build tanks and warships.
It is one of the things that the US is still doing right. Lots of money is poured into basic research. Not all of them are used to build tanks and warships.
Yeah, my first programming gig was doing research for an open source DoD compilers project (ROSE) run by the DOE at LLNL
This research may be funded as part of the US "Cancer Moonshot" program started in 2016 [1]. VA hospitals serve millions of patients every year.
[1] https://www.defense.gov/News/News-Stories/Article/Article/30...
[1] https://www.defense.gov/News/News-Stories/Article/Article/30...
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Between the carcinogens in the water at bases and the fumes from plastic in burn pits, it's not that surprising they'd want to cure cancer. Anyways it's a program administered by the DoD.
Just entering phase I.
> AOH1996 [...] is exclusively licensed by City of Hope to RLL, LLC, a biotechnology company that Malkas co-founded and holds financial interest in...
> AOH1996 [...] is exclusively licensed by City of Hope to RLL, LLC, a biotechnology company that Malkas co-founded and holds financial interest in...
I'm very happy this article keeps popping up on HN, but the tests have been on mice and dogs thus far. More info:
Full:
https://www.cell.com/cell-chemical-biology/fulltext/S2451-94...
Clinical trials:
https://www.cancer.gov/about-cancer/treatment/clinical-trial...
Derek Lowe's response on AOH1996:
https://www.science.org/content/blog-post/new-mode-cancer-tr...
The drug that came before it, AOH1160, but didn't metabolize well:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279569/
Other new, interesting anti-cancer drugs:
https://med.stanford.edu/cancer/about/news/rewiring-cancer-c...
https://www.nature.com/articles/s41586-023-06348-2
Full:
https://www.cell.com/cell-chemical-biology/fulltext/S2451-94...
Clinical trials:
https://www.cancer.gov/about-cancer/treatment/clinical-trial...
Derek Lowe's response on AOH1996:
https://www.science.org/content/blog-post/new-mode-cancer-tr...
The drug that came before it, AOH1160, but didn't metabolize well:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279569/
Other new, interesting anti-cancer drugs:
https://med.stanford.edu/cancer/about/news/rewiring-cancer-c...
https://www.nature.com/articles/s41586-023-06348-2
Oral cancer drug kills 100% of tumors in vitro and in animal models - https://news.ycombinator.com/item?id=37003617 - Aug 2023 (102 comments)
A New Mode of Cancer Treatment - https://news.ycombinator.com/item?id=36982813 - Aug 2023 (208 comments)
New targeted chemotherapy able to kill all solid tumors in preclinical research - https://news.ycombinator.com/item?id=36978199 - Aug 2023 (32 comments)
'Cancer-killing pill' is now being tested on humans - https://news.ycombinator.com/item?id=36969500 - Aug 2023 (31 comments)
Cancer pill AOH1996 shows promise in annihilating all solid tumours - https://news.ycombinator.com/item?id=36960895 - Aug 2023 (20 comments)
Cancer pill AOH1996 shows promise in annihilating all solid tumours - https://news.ycombinator.com/item?id=36960292 - Aug 2023 (16 comments)
A New Mode of Cancer Treatment - https://news.ycombinator.com/item?id=36982813 - Aug 2023 (208 comments)
New targeted chemotherapy able to kill all solid tumors in preclinical research - https://news.ycombinator.com/item?id=36978199 - Aug 2023 (32 comments)
'Cancer-killing pill' is now being tested on humans - https://news.ycombinator.com/item?id=36969500 - Aug 2023 (31 comments)
Cancer pill AOH1996 shows promise in annihilating all solid tumours - https://news.ycombinator.com/item?id=36960895 - Aug 2023 (20 comments)
Cancer pill AOH1996 shows promise in annihilating all solid tumours - https://news.ycombinator.com/item?id=36960292 - Aug 2023 (16 comments)
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Sounds like it's meant to single out dividing cells with damaged DNA. But something broad-acting seems more likely to carry unintended consequences. (Eg, if it turns out all liver cells 'look' damaged.) And this is why we have multistage trials.