The emotional side of me says: Don't run from something, run towards something. Whenever I catch myself convincing myself to accept a job, I know to reject it.
On a more practical level, I score things that are important to me. E.g. Flexibility, company, values, salary etc. Then I try to make a decision only after I scored each of these. Coincidentally, this also helps when I negotiate a new job: Can't pay me more? How about I get more holiday?