1.1.1.1
2001:4860:4860::8888
9.9.9.9
2606:4700:4700::1111
8.8.8.8
2620:fe::fe
1.0.0.1
2001:4860:4860::8844
149.112.112.112
2606:4700:4700::1001
8.8.4.4
2620:fe::9
will failover faster and more successfully on systemd-resolved, than if you specify all Cloudflare IPs together, then all Google IPs, etc.
One benefit of Microsoft requiring them for Windows 11 support is that nearly every recent computer has a TPM, either hardware or emulated by the CPU firmware.
It guarantees that the private key can never be exfiltrated or copied. But it doesn't stop malicious software on your machine from doing bad things from your machine.
So I'm not certain how much protection it really offers on this scenario.
Linux example: https://wiki.gentoo.org/wiki/Trusted_Platform_Module/SSH
macOS example (I haven't tested personally): https://gist.github.com/arianvp/5f59f1783e3eaf1a2d4cd8e952bb...