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ashwal

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No models are perfect, but Biotech's are terrible

adamashwal.com
3 points·by ashwal·vor 4 Jahren·0 comments

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ashwal
·vor 4 Jahren·discuss
This is much more than I would have guessed!

Considering how recent ~any level of EV mass manufacturing is v.s. the total stock and new purchases of ICE cars, a material dent seems rather impressive?

Why we always gotta be so cynical ¯\_(ツ)_/¯
ashwal
·vor 4 Jahren·discuss
Their measurements (Figure 4) directly contradict this so they add another variable to their model ¯\_(ツ)_/¯

Task performance & subjective rating don't change between the two groups.

The measurements are crude.

There's a lot of degrees of freedom in this study. Useful for others in the field, but a popular writeup deserves to go in the bin
ashwal
·vor 4 Jahren·discuss
Some good tips in here, I've find myself reaching for JSON/excel methods often.

Despite using it for years, I still haven't decided if pandas is poorly architected or if the clunkiness (for lack of better of term) is a result of the inherent difficulty of the tasks.
ashwal
·vor 4 Jahren·discuss
Which book, do you recall?
ashwal
·vor 5 Jahren·discuss
They're probably referring to: https://pubmed.ncbi.nlm.nih.gov/11909679/

I think this is one symptom of a much greater issue: the inbred mice strains we use are disastrously weird (arising from the initial population artificially bred to make research easier). For the sake of controlling for genetics, we've chosen to make lab research translation drastically less effective.
ashwal
·vor 5 Jahren·discuss
There's many papers showing similar. (My personal favorite is https://www.science.org/doi/10.1126/scitranslmed.aaw8412 where they removed the claimed target for various cancer therapies and many still worked)

If you've ever been within a mile of a research lab this shouldn't be remotely shocking. Typical research is done rapidly, sloppily, and in a context where getting the "right" answer is the only incentive.

The replication crisis that hit psych is only being held back by (IMO) that bio is harder to replicate due to tooling, protocols, reagents, cell lines, etc.

In complex systems you have the degrees of freedom to be wrong at a scale that folks still do not appreciate.