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martynr

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Landmark Trust UK – holidays in historic buildings

landmarktrust.org.uk
1 points·by martynr·letztes Jahr·0 comments

New study puts gut microbiome at the center of Parkinson's disease pathogenesis

uab.edu
4 points·by martynr·vor 2 Jahren·1 comments

comments

martynr
·vor 2 Jahren·discuss
Could it rather be that genZ are risk averse and choose not to volunteer to be shot at? Or even that they have greater moral concerns than earlier generations? (No judgement on that implied, complexities acknowledged)

That said, personally can’t see how a show would be much help either.
martynr
·vor 2 Jahren·discuss
Unlikely to be a popular question in this forum but in my view the most important topic we need to reflect on is “are we really better off with these services?” - obviously at face value there is utility or there wouldn’t be the market penetration but the externalities and issues of market dominance are becoming more apparent and pressing.

And if we agree that better solutions are needed then the question becomes “how do we create the market conditions that support those better outcomes?”

I’d really like to see kk reflect on this article with 10 years hindsight and see if he remains optimistic.
martynr
·vor 2 Jahren·discuss
Genuinely curious- In what sense is the risk calculated? I understand that the leverage factor is known but fundamentally isn’t this still just a bet that eth will rise? And if it falls then won’t the loss be multiplied by the same leverage factor?

Obviously you can research the eth market and form a view but you can also research horse racing form and the odds themselves should be a fair calculation indicator if the betting market is working well - so it seems fair to suggest that this is in the same category as a horse racing bet.
martynr
·vor 2 Jahren·discuss
This would be totally necessary for a robust conclusion-trust me, the social cues of having PD are not subtle ;)
martynr
·vor 2 Jahren·discuss
The associated paper is excellent and available on open access here:

https://www.nature.com/articles/s41467-022-34667-x
martynr
·vor 2 Jahren·discuss
This seems consistent with research from the University of Alabama that demonstrates substantial differences between Parkinsonian gut microbiome and control subjects- very plausible (IMO) that this might result in smell differences.

The Alabama paper is open access and well worth reading if you’re interested in Parkinson’s

https://www.uab.edu/news/research/item/13280-new-study-puts-...
martynr
·vor 2 Jahren·discuss
It’s not the winning, it’s the taking part
martynr
·vor 2 Jahren·discuss
Surely this can’t be justified as a ux driven “oversight” - I am not an economics professor but I would be feeling totally sketchy if I manipulated a data source in such an apparently arbitrary manner.

In combination with the (reportedly)blatant lack of any reference to the methodology in his paper this feels like wilful gross misconduct in professor-land.

IMO this sort of thing rightly undermines confidence and credibility of research in a much broader context and should be a sackable matter if shown to be true as asserted.
martynr
·vor 2 Jahren·discuss
Adjacent to this, I recommend reading (and perhaps even sharing with your parents) “Being Mortal” by Atul Gawande. It is a masterpiece on the reality of aging and what is important in managing the process towards a good life and ultimately death.

As someone dealing with a long term, chronic, progressive and currently incurable condition I can say that for me it really helped to find a better focus and conversation around what is important and how to communicate needs and desires towards good outcomes.