That's actually what I didn't understand in Dan Abramov's response ...
If you run a synchronous function that takes 2 seconds your app will block whether you use Svelte or React or whatever. You need to offload it to a webworker anyway.
Still I think it's a good idea to update the DOM not more often than needed: Only update the last change of an element every 23 ms and skip the changes that have been overriden. You can do this without a virt DOM.
The choice has to be made by ecosystem, programming style, etc.
React as a library offers not enough for me personally. Angular is too heavy on concepts. Vue seems to hit the sweet spot?