suzumer · HackerTrans

letztes Jahrdiscuss

Because a language being NP-hard implies it is at least as hard as the hardest NP problems. For any language that is NP-hard, if one had a turing machine that decided the language, one could construct a polynomial time transformation of any language in NP to the NP-hard language to decide it using the NP-hard turing machine.

suzumer

letztes Jahrdiscuss

This doesn't track my experience. I have Ewing's Sarcoma, and my first regimen involved 5 agents: Doxorubicin, Vincristine, Cytoxan, Ifofsfomide, and Etoposide. This [1] appears to be the same plan I used. When that failed, I had a second regimen with Vincristine, Irinotecan, and Temozolomide. After that failed, I had Irinotecan and Trabectidin, followed by Doxil, followed by, Cytoxan and Topotecan, followed by high dose Ifofsfomide. So only two of the treatments I received were single agent, but maybe it depends on the cancer.

[1] https://www.cancerresearchuk.org/about-cancer/treatment/drug...

suzumer

letztes Jahrdiscuss

I thought using multiple therapies for cancer was fairly common, or are you referring specifically to immunotherapies?

suzumer

letztes Jahrdiscuss

According to this [1] wikipedia article, the only feature Sapphire Rapids doesn't support is VP2INTERSECT.

[1]:https://en.wikipedia.org/wiki/Advanced_Vector_Extensions

suzumer

letztes Jahrdiscuss

At the time, there was essentially a 50/50 chance it was a lab leak or from a wet market. The issue with saying it was a lab leak at that time is that you are essentially gambling the US's relationship with China should it come out that it was a from a wet market. Also, a lot of the discussion regarding the lab leak theory early on seemed to me like it wouldn't be sated even if the US presented sufficient evidence that it was from a wet market.

suzumer

letztes Jahrdiscuss

Saying COVID-19 leaked from a lab with zero evidence is different than waiting for evidence and then saying it leaked from a lab.

suzumer

vor 2 Jahrendiscuss

The issue there is that the listens from people who listen to less music would be worth more than the listens from people who listen to more music.

suzumer

vor 2 Jahrendiscuss

Cern uses cling now (https://github.com/root-project/cling)

suzumer

vor 2 Jahrendiscuss

Mark Fairchild, one of the authors of CIECAM02, recently published a paper that heavily simplified that equation: https://markfairchild.org/PDFs/PAP45.pdf

If the link doesn't work, the paper is called: Brightness, lightness, colorfulness, and chroma in CIECAM02 and CAM16.

Also, if you want a readable introduction to color science, you can check out his book Color Appearance Models.

suzumer

vor 2 Jahrendiscuss

I haven't gone through the whole article, but it seems to be conflating chroma and saturation. If lightness of a color is scaled by a factor c, then chroma needs to be scaled by that same factor, or saturation won't be preserved, and the color will appear more vibrant then it should.

suzumer

vor 2 Jahrendiscuss

Do you live in Canada?

suzumer

vor 2 Jahrendiscuss

CAM16's hue lines are curved by design. Hue is not linear with regards to xy chromaticity, as evidenced by the Abney effect[1].

[1] https://en.wikipedia.org/wiki/Abney_effect

suzumer

vor 2 Jahrendiscuss

While one commenter had it somewhat right that HDR has to do with how bright/dark an image can be, the main thing HDR images specify is how far ABOVE reference white you can display. With srgb, 100 percent of all channels is 100 percent white (brightness of a perfect lambertian reflector). Rec 2100 together with rec 2408 specify modern hdr encoding, where 203 nits is 100 percebt white, and above that would be anything brighter (light sources, specular reflection, etc). So if a white image encoded in sdr looks dimmer than hdr for non specular detail, that is probably encoding or decoding error.

suzumer

vor 2 Jahrendiscuss

Cam16 (as opposed to cam16 ucs) is perception based. It calculates chroma, lightness, and hue, and is based on the munsell color system. Hellwig and Fairchild recently simplifed the model mathematically, improving it's chroma accuracy.( http://markfairchild.org/PDFs/PAP45.pdf) Another, simpler, model is CIELAB, which outputs paramters L, a, and b, where L is lightness, hypot(a,b) is chroma, and arctan2(b,a) is the hue.

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