Tbh, when I bought my iPad and you didn't need to register it via iTunes I was relieved. For 3 years I didn't connect it to the computer so it never touched iTunes - this is how much I hate iTunes.
+ I am always afraid that if you sync with iTunes (yeah, soooo 2007) that I am going to lose something somewhere, a file, a tune, image or - for sure - a PDF in iBooks.
I've had so many things "lost" that way. Without warning, or a summary or an opportunity to make my decision.