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markusstrasser

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Bioinformatics Pipeline Example from the Bottom Up

ricomnl.com
2 points·by markusstrasser·4 years ago·0 comments

Ways to Accelerate Aging Research

longitudinal.blog
2 points·by markusstrasser·5 years ago·0 comments

What's Wrong with Social Science and How to Fix It:Reflections After 2578 Papers

fantasticanachronism.com
2 points·by markusstrasser·5 years ago·1 comments

NewLimit: a company built to extend human healthspan

blog.newlimit.com
64 points·by markusstrasser·5 years ago·136 comments

comments

markusstrasser
·8 months ago·discuss
Author here. Somehow the worst thing I ever wrote is on the front page of HN.

I wrote this fast so there's jargon and bad prose. The title is deliberately dry and bland so I wasn't expecting anyone to click it. Also I slightly changed my mind on some of the claims .. might write up later.

The main reason I like to think of creative work in a more abstract/formal/geometric way (acceptance volume, latency, sampling) is it's easier for me categorize tasks, modalities and domains and know how to design or work around it. It's very much biased by more own experiences making things.

Also, abstract technical concept often come with nice guarantees/properties/utils to build on .. some would say that's their raison d'être.

Re comments: * "this is just diminishing returns" -- ok and this is a framework for why: the non-worsening region collapses, so most micro-edits fail

* "bands record bangers in an hour" –– practice tax was prepaid. The recording session is exploitation/search riding on cached heuristics imo (and it still takes hours of repeated recording/mixing/producing to actually produce a single album track).

* music key example –– yes I should've picked a different one. Main point was that some choices create wider tolerance (arrangement/range/timbre) even if keys are symmetric in equal temperament
markusstrasser
·11 months ago·discuss
the interesting web problems (collaborative tools, creative software, scientific computing) have to fight against a framework ecosystem designed for the blandest landing pages.

Nextjs and most web frameworks assume you're building an e-commerce site that has to only differentiate on loading speeds.
markusstrasser
·11 months ago·discuss
Fair enough. IMO the best solution is/was always hiccup (cljs) since it has no extra syntax to the core of the language (vectors/maps)
markusstrasser
·11 months ago·discuss
Wrong frame. It's just a playground
markusstrasser
·11 months ago·discuss
It's great people experiment. Yet, after a quick glance the framework seems to break expected semantics for no gain? For example: the "component" construct auto-renders the JSX within the brackets instead of being a function that "returns a view as value" (if I understood correctly). I'm cool with breaking the "f(x)=>UI" but what for? The TS and VS Code integration is all fine and good but what's the gain of using JSX (again) instead of the beloved HTML-like Svelte markup? Have people ever loved JSX? Nostalgia maybe? Again, I'm all for tearing down the house but shouldn't we get more elegance or expressive semantics in return?

Still, great he did it I just hope he'll be bolder next time! Of the 7 mentioned features 3-4 are not actually about the language but minor tooling hook ins (prettier, VSCode,) ... maybe that's the wrong focus.

Either way, the strong similarity with other JS/TS frameworks (semantics & syntax) suggests that for really new ideas the community should look elsewhere? Perhaps Clojurescript or Laravel (PhP) ...
markusstrasser
·2 years ago·discuss
smarter waifus for the wicked
markusstrasser
·3 years ago·discuss
It's a glorified youtube channel. Not a technology. That's most of the crux. It worked because Khan was early and made good content
markusstrasser
·3 years ago·discuss
Why are people getting hung up on his hubris? If his megalomania gives us Mathematica who cares. It's a phenomenal accomplishment. It can, out of the box, do hundreds of things that'd take you weeks in python/julia/etc or would be entirely impossible for most in other systems.
markusstrasser
·3 years ago·discuss
sad that this guy could've continued doing good CS research as assoc prof but instead is compelled to do youtube and sell productivity courses of the three same rehashed ideas ad infinitum.
markusstrasser
·3 years ago·discuss
+1
markusstrasser
·3 years ago·discuss
he's been following his own advice religiously for years
markusstrasser
·5 years ago·discuss
Patents were the more obvious go to but we didn't want to work with obfuscated patent descriptions for the next years
markusstrasser
·5 years ago·discuss
But you're right; open source projects for extracting infos (like PubTator) are valuable but ontologies/KGs need ongoing expert (ML, AI, SWEs, information architects, labelers) work (unlike most of Wikipedia or GH) so it's tough to make something that doesn't suck in a distributed open source fashion
markusstrasser
·5 years ago·discuss
"follow the best institutions and ~50 top individuals" wasn't meant as a suggestion actually, just an observation of what most people do.

You're right they "could work if designed to solve a specific real world problem" but against what baseline? The baseline could be spending that time on actual deep tech projects and not NLP meta-science
markusstrasser
·5 years ago·discuss
Hey, author here. Great discussion so far. Will update the post with some of the comments and critiques.
markusstrasser
·5 years ago·discuss
You hit the nail on the head. Will put some of that in the appendix of the post!