Extremely difficult, but more likely than artificial meat, it isn't so much the life support system as the constant contamination and lack of immune system that kills in vitro neuron cultures.
It is much more efficient to use in vivo neurons since they come with an immune system attached and work just as well for leaning tasks.
This is closer to rent a transistor, and the main use case is to find out what its voltage curves are.
It is not a computer.
I did work on a version which used in vivo brains for actual computation. It worked but no one wanted to invest in building the matrix for rodents. With the benefit of hindsight I shouldn't have added the slide explaining ethical considerations: 'Container Labs in international waters help us manage regulatory risks'.
It is much more efficient to use in vivo neurons since they come with an immune system attached and work just as well for leaning tasks.