Yeah, no shit. As a non-tech person who has tried to use it for non-tech stuff: Having the compulsively-lying, halluciating POS algorithm that everyone thinks is the second coming of Christ burn an obscene amount of non-renewable energy to create said lies while my company wants us to train it to steal out jobs is kinda something I'm not interested in.
How is training my replacement on a plagiarism machine that is actively putting people (including myself) out of the job while destroying the environment (but whose results are still not as good as a human) in any world a good thing?
There is no boost in productivity for non-tech related stuff. If you need to double-check the output, it is de facto not as productive as a human, since you need to effectively do the work twice.
Also, it adds nothing of value where is is being crammed into everything, and just seems to be a cynical techbro PE driven buzzword play.
Science fiction beat the author of this article to the punch re: novel cooling solutions in space. The author proposes squirting oil from one arm, through open vacuum, to another arm - the oil droplets radiate the heat en route from arm 1 to arm 2. However, like most modern tech, science fiction writing has anticipated it. In the book Saturns Run (2015), by John Stanford and Ctien, their spaceship cools down it's megawatt nuclear reactor by using a eutectic metal as coolant, which runs as a molten ribbon through open vacuum from arm 1 to arm 2.
My take is also a missile, but as an interceptor, not offensive purposes. North Korea has shown that they can deliver a payload to Japan if they want. If the NKs do decide to launch something at Japan, it's not going to be tipped with conventional explosives. It'll be a nuke. Hypersonic interceptor seems the more likely application is this tech to me.
Long-time ebay seller here. I'm seeing comments floating towards the top that are essentially positing that the physical GameStop locations can be used as hubs where people can buy or sell their stuff in general (especially items that are 'pick-up only'). A pawn shop, basically.
Thing is, GameStop is, well, for videogames and videogame paraphernalia. It's not a general store. Doing this would turn them into a thrift shop, not a pawn shop, as people are trying to offload their carpets, desks, etc - bulky stuff.
I don't think this makes sense.
This does make sense when you consider the collectable market, another domain I'm involved in. Trading card games, specifically pokemon, have exploded over the last 5 years. GameStop is making a killing off of buying, selling, and grading these cards. Ebay is the primary marketplace to buy and sell those cards. There's also tax free havens ("Vaults") offered by multiple companies, grading service passthroughs, and scalping offered through ebay too.
Viewed through the above lens, that's what's prompting this offer, I think.
> They paid a total of 2 people $50,000 (edit: in 2016 dollars). That doesn't seem like enough to entirely shape worldwide discourse around nutrition and sugar.
You would be astonished at how little it takes to bribe, I mean donate, to a politician for example. For as little as $10-20k USD you can get a literal seat at a table with a sitting senator or congresscritter for several hours at a "charity" dinner, with results as expected.
You are absolutely bonkers. This post and the rationale behind it are beyond insane.
We do not understand these ecosystems beyond their extreme fragility and low entropy conditions. This is an incredibly destructive and expensive manner of resource extraction that destroys the seabed. Why would anyone sane ever support this beyond, I don't know, someone who also thinks that clearcutting the amazon is a good idea? What kind of vested interest do you have in this blighted technology?
Keytruda, pembrolizumab, (what he probably received) can only do so much. If it was in his GI tract it was also elsewhere in multiple places. The PD-L1 drugs at this point have more than 400k patients treated, with decent efficacy. I'm sorry for your loss. If his melanoma had metastasized to his GI tract it was too late for anything except palliative care.
This drug has been used in a huge number of patients for more than 11 years; the next gen of drugs is currently being used. I'm sorry for my curt style of writing, but - people like your father have helped pave the way for that next generation of drugs by constraining clinical trial designs.
Sorry, as someone in this field, this is bullshit. It is in mice.
Several things trigger my bullshit meter. Quote:
"This dramatically surpasses the therapeutic efficacy of current standard treatments, including immune checkpoint inhibitors (anti-PD-L1 antibody) and liposomal doxorubicin (chemotherapy agents)"
PD-L1 monoclonal antibodies are only effective against cancers that are, you guessed it, PD-L1 positive. At high percentages, ranging from 1 to 50%. Are these authors even familiar with the state of the art when it comes to cancer medications? Mouse tumors do not equate to people tumors. Many tumor types are not PD-l1 positive.
Doxy is an ancient SOC chemo.
This is a nothing burger.
Give me phase II/III clinical trials, and then let me know what their PFS/OS was after 5 years. and what the medians were at 3- and 5-years. Also, ORR and CR and needed.
CAR-T is ahead of the game, and will be the ultimate winner here as it grows to scale.
I feel like many of the comments are focused on the trees and not on the forest. The new head of Facebook AI is 28 years old? That's not OK, that's too young. Too inexperienced and not worldwise enough by a long shot. No shit they're having problems. Can you imagine being a facebook lifer, or one of the LLM pros they've bribed/hired over to the company, to be bossed around by someone with very little life experience? No shit it isn't going well.
The only benefit as I perceive it re: orbital data center hardware is regulatory avoidance. Think...DDOS machines that can't be shut off; or financial hosting services for unsavory individuals. However, it's very expensive by all metrics (including those talked about in the article), and frankly, these satellites are sitting ducks for the hunter killer satellites the various space powers have, if they actually wanted to do something about these hypothtical data centers and the problems they would cause.
So, I'm going to chip in with a different perspective from that of some other commentators on here. The overwhelming majority of computers in the entire world, used by our entire species, have windows as their OS.
While I applaud the use of alternatives to windows and it's apps, universities teach it because it is what their graduates will use in the real world. Governments use it because while it has it's flaws, it mostly works and is a universal standard. It's the toyota of operating systems. The parts and manpower to repair it and use it are available everywhere, and it's cheap and reliable.
There have been several proposals. This paper proposes a feasable mechanism[1]:
-"a SBH could be artificially created by firing a huge number of gamma rays from a spherically converging laser. The idea is to pack so much energy into such a small space that a BH will form."
https://en.wikipedia.org/wiki/Wikipedia:Administrators'_noti...