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rdgthree

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Continuous inhalation of essential oil increases gray matter volume in the brain

pubmed.ncbi.nlm.nih.gov
1 points·by rdgthree·5 months ago·1 comments

Solubility in olive oil predicts anasthetic potency of a compound

en.wikipedia.org
3 points·by rdgthree·5 months ago·0 comments

A dead fish moves upstream when its body resonates with vortices in water [pdf]

liaolab.com
5 points·by rdgthree·6 months ago·1 comments

Alzheimer's disease starts in childhood in polluted Mexico City (2020)

pubmed.ncbi.nlm.nih.gov
5 points·by rdgthree·7 months ago·0 comments

Incidence of Dementia Before Age 65 Among 9/11 Attack Responders (2024)

jamanetwork.com
9 points·by rdgthree·7 months ago·0 comments

If a Meta AI model can read a brain-wide signal, why wouldn't the brain?

1393.xyz
141 points·by rdgthree·7 months ago·92 comments

Alzheimer's is the symptom, not the problem

1393.xyz
3 points·by rdgthree·7 months ago·0 comments

[untitled]

1 points·by rdgthree·7 months ago·0 comments

[untitled]

1 points·by rdgthree·7 months ago·0 comments

Could the root of Alzheimer's be magnetic?

1393.xyz
2 points·by rdgthree·8 months ago·5 comments

comments

rdgthree
·2 months ago·discuss
xAI had a lot of negotiating power here because Anthropic had ~0 comparable options and ultimately desperately needed the compute now. So, it wouldn't surprise me if data sharing was an explicit part of the agreement
rdgthree
·7 months ago·discuss
Nothing to add to this conversation in particular, but just wanted to say - truly amazing paper. Well done!
rdgthree
·7 months ago·discuss
Should have added one sooner! Here you go: https://1393.xyz/rss.xml
rdgthree
·7 months ago·discuss
I appreciate that you feel this way, but the mechanisms behind exactly which neural circuits are activated by TMS are simply not yet fully understood.

From 2024:

> Transcranial magnetic stimulation (TMS) is a non-invasive, FDA-cleared treatment for neuropsychiatric disorders with broad potential for new applications, but the neural circuits that are engaged during TMS are still poorly understood.

[0]https://journals.plos.org/ploscompbiol/article?id=10.1371%2F...
rdgthree
·7 months ago·discuss
Of course!

But also:

> Although the biology of why TMS works isn't completely understood, the stimulation appears to affect how the brain is working.

https://www.mayoclinic.org/tests-procedures/transcranial-mag...

I think it's reasonable to assume there's room to sharpen our understanding of it quite a bit.
rdgthree
·7 months ago·discuss
The whole argument hinges on the idea of tuned resonance: https://www.nature.com/articles/s41598-025-07988-2
rdgthree
·7 months ago·discuss
If you're interested in my personal chain-of-thought on the subject:

This was where I started pulling this thread (October 2025): https://1393.xyz/writing/could-the-root-cause-of-alzheimers-...

And this is an even further ancestor of the ideas (December 2023): https://1393.xyz/writing/are-we-only-conscious-while-were-le...

I'm operating off of my own subjective experience, and this idea lines up tightly with System 1 and System 2 in cognitive psychology.

It seems that many jump to "AI psychosis" when one mentions magnetic fields, but the evolutionary tree is very straightforward:

1. Nature evolves magnetoreception for navigation

2. Eventually, a brain in nature with magnetoreception accidentally "hears" its own magnetic field with with resonance

3. That lossy global summary of the brains ends up being an evolutionarily advantageous "higher-order sense"

4. Evolution sharpens the blade for many years

On first principles, that seems perfectly viable and even likely given that magnetoreception was such a boon for survival for all life.

Just glad others are finding it interesting!
rdgthree
·7 months ago·discuss
Not necessarily - I think it works like Daniel Kahneman's System 1 and System 2. Your conscious system is System 2 - when it's not working correctly, you just fall back to System 1.

Independently, since the whole idea relies on resonance, it may be the case that an fMRI doesn't actually interfere with the "stochastic resonance" mechanic quite like TMS (transcranial magnetic simulation) seems to.

If you model the brain this way, dementia looks like a clear breakdown of System 2, which is an interesting thought experiment even if the mechanics aren't perfect: https://1393.xyz/writing/alzheimers-is-the-symptom-not-the-p...
rdgthree
·7 months ago·discuss
In cognitive psychology there's all sorts of evidence that we have two distinct processes, but I don't think anyone has really mapped it to a physical system yet.

Modeling two physical systems is pretty interesting though because dementia ends up looking like a clear failure of System 2. Really neat idea generator even if imperfect.
rdgthree
·7 months ago·discuss
I think Daniel Kahneman's System 1 (habits, unconscious) and System 2 (learning, "error correction", conscious) are physical systems, and System 2 takes a LOT more energy to run.

So, when you get tired, System 2 leans more and more on the much more energy efficient System 1. So you get behaviors that look like unrestrained habits: poor impulse control, lowered emotional regulation, etc

Edit: I wrote more about this idea if anyone is curious: https://1393.xyz/writing/alzheimers-is-the-symptom-not-the-p...
rdgthree
·8 months ago·discuss
Did you read it?
rdgthree
·8 months ago·discuss
These have always felt like symptoms of the problem to me, so perhaps just downstream effects! Definitely not sure, obviously plenty of complexity to this one.
rdgthree
·6 years ago·discuss
I think this is the interesting question. I'm an extremely deep sleeper and almost nothing wakes me up while I'm sleeping, but I've found that I naturally sleep significantly longer if my bedroom has too much light or there's a significant amount of noise around me while I'm asleep. So despite not actually waking up consciously, I think I sometimes end up in this partial wake state where I'm not getting proper REM sleep and as a result, not actually getting the rest I need.

It wouldn't surprise me if this is often the case for people who feel they need more sleep. Having proper blackout shades and full silence (via ear plugs or otherwise) during sleep allows me to sleep a significantly shorter period of time as measured by however long I end up staying asleep. I typically don't use an alarm, so it's fascinating to be able to notice that natural difference in how long my body seems to need before booting back up.

Interesting anecdote - the pandemic is what triggered my awareness of this effect. When I'm at home alone sleeping (typically into the late morning, I'm a night owl), my dog will sleep with me. When my girlfriend started working from home from early in the morning, he would wake up with her and bark loudly at the occasional activity outside. I suddenly couldn't wake up on my normal schedule, even though I wasn't actually consciously woken up by the barking. The thought occurred to me that it could still be the barking and something related to the depth of the sleep, so I tried ear plugs + having my girlfriend close the bedroom door. Suddenly I was back to sleeping normal hours. Years of strange sleeping pattern problems were explained in an instant.
rdgthree
·6 years ago·discuss
I would imagine the group of people who immediately accepted everything this book claimed as fact and went on to immediately adjust their lifestyles to match may have a strong correlation with the group of people who are more susceptible to the placebo effect.

I didn't make it through the first chapter before I started looking into the accuracy of the claims he was making. Some of them were clearly bananas.
rdgthree
·6 years ago·discuss
Immensely frustrating how many people are citing his book in a thread about one of your own blog posts, of all places. I was so glad to see your post about it at the time, and this experiment is an interesting follow up.

"Why We Sleep" is everything wrong with "science" today, and as a person who also isn't a huge fan of sleeping, I'm desperate to understand the real drawbacks to a lack of sleep. That dumpster fire of a book has set back honest research on the subject by years.

Just venting, as I know you agree. Thanks again for your contributions to sanity.