what we’re seeing now is that the immune system can go into overdrive, where certain immune cells trigger sepsis-like illness, sometimes in milder or chronic ways. long covid and related conditions seem like part of that same spectrum of immune dysfunction.
the nih recover autopsy studies are also finding viral persistence in multiple organs, with more results coming soon
https://recovercovid.org/pathobiology
i work on multiple NIH RECOVER efforts on this topic and post long covid research on x, and honestly the picture is both fascinating and pretty grim
https://x.com/atranscendedman
They fund and do a lot of work beyond the horrible choices for initial RCTs. This fall we should hopefully see actual pharmaceutical interventions and a plethora of research they’ve been publishing.
The more important parts of their programs are the omics and tissue biopsy programs.
Very likely. All of these illnesses are diseases of the cells. We're entering the golden age of immune cell science. You figure out what immune cells are causing disease and how to restore them.
Here the T cells are imbalanced and a specific protein is found to regulate the imbalance but the interferon is countering the protein's effects. Now you can target that in many ways and run all sorts of clinical trials.
Many ME experts are doing both. RECOVER is considering adding ME/CFS arms to its huge clinical trial platform. UCSF just added ME/CFS as a priority in their LIINC program.
SARS-CoV-2 therapeutics won’t work on both but immune cell based ones may given they haven’t been tested in either yet.
Both suggest a root cause of persistent viral antigen. Time will tell what works here.
I really like https://readwise.io/ for this purpose regarding all the books I've read and the quotes I like to re-visit here and there. It uses a SRS technique.
While this type of article is almost cliche at this point regarding someone coming across the memory limitations and the power of anki for the first time, I really think the case for anki is exaggerated with "important ideas".
Anki is great for preparing to go on jeopardy or being in say med school. It is not really needed for lifelong learning.
Wrote a book covering this topic this year. You could live an entire life not being bored. There’s definitely different types of boredom and we are constantly distracted from the good kinds.
One theory is that we're not aware nor can break free from the three major types of anxiety in life such as fate and death, emptiness and loss meaning, and guilt and condemnation.
We struggle to find peace with #2 and #3 given #1 will always be present in life.
Shakespeare knew this given how often he asked the question of "to be or not to be".
Some ecosystems adopt latest semantic version (i.e. caret/hat versions).
Some ecosystems adopt lowest applicable version (i.e. explicit/implicit ranges).
Although this may be more specific to the former ecosystems, I think the real lesson here is that there's associated risk with not pinning your dependencies in favor of receiving security/bug fixes. Yes, lock files are a thing, but there's still a real downstream effects to these things when they are regenerated/created.
Was the author within their rights to do this? Absolutely.
Was the package manager within their rights to mitigate harm? Absolutely.
These actions do not go without consequence. Time will tell what those are exactly. This is not the first time this happened, and it won't be the last.
there’s some great new research out of the university of virginia looking into this https://www.science.org/doi/10.1126/science.adq2509
mis-c and the adult versions are rare but real, and there’s early promise with a treatment called larazotide https://www.science.org/doi/10.1126/scitranslmed.adu4284
the nih recover autopsy studies are also finding viral persistence in multiple organs, with more results coming soon https://recovercovid.org/pathobiology
i work on multiple NIH RECOVER efforts on this topic and post long covid research on x, and honestly the picture is both fascinating and pretty grim https://x.com/atranscendedman