I would think there wouldn't be much of a difference because the smallest unit you can really work with on modern computers is the byte. And whether you use 8 bits to encode a byte (with 256 possible values) or 5 trits (with 243 possible values), shouldn't really matter?
Wow, this is all I ever wanted. The only thing that's maybe missing is a natural way to do captions for images and tables, and a syntax for spoilers. But these can probably be built on top of the div and span syntax.
[0]: https://chaos.social/@yorgos/115931944888149528