I wouldn't say Missoula is far off into the woods, but maybe that's just where you want to be; sorry if I misunderstood you.
I think about remote work drying up often, but I think if remote work dried up for me it would mean there was a major shift in the industry, so I don't think anyone would be safe from that.
Being near an urban center would mean that you could possibly pound the pavement for a new job in a major city a lot easier. If the industry changes massively, will being near an urban center mean there will still be a lot of jobs there? Maybe? Maybe not.
I lived in San Francisco for the past seven years, but moved to Missoula, Montana because living in the city and even surrounding places like Oakland, South Bay was increasingly way too expensive. I count myself lucky that I am self-employed and work in an industry that I can easily do remote work as the job prospects in Missoula mostly center around low-wage service work.
At the end of the day, I moved to Missoula so I can do my part as a millennial and start buying diamonds again.