Use of adenovirus type-5 vectored vaccines: a cautionary tale(thelancet.com)
thelancet.com
Use of adenovirus type-5 vectored vaccines: a cautionary tale
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32156-5/fulltext
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32156-5/fulltext
https://www.sciencemag.org/news/2020/10/could-certain-covid-...
The concerns raised in this article do not speak to the efficacy of candidate vaccines using Ad5 vectors. Rather, they discuss the potential impact Antibody-dependent enhancement might have on at risk groups, and, as a consequence, for the design of clinical trials using those vectors.