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DarwinsToffees

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DarwinsToffees
·il y a 10 mois·discuss
I also work in this field and while I largely agree with you, cell therapy is one of the hardest hit fields right now financially and investing in big shots to do something like dual edited islet cells is probably not going to happen. Maybe in the distant future, but right now I don't see someone going for that seriously in a clinical setting.
DarwinsToffees
·il y a 10 mois·discuss
Kill switch is a possibility, but once you start adding more than one item to a cell it doesn't always work out. What I mean is that the number of cells that successfully take both edits and continue to operate normally or survive the editing process drops considerably.

You are correct that current cell transplant therapies exist, but I don't believe any before have contained these immune escaping edits and I believe all of those treatments are cancer treatments which allow for a different level of risk. Diabetes is a very serious disease but a quality of life treatment does exist and having cells result in a potential cancer in patients would not be acceptable as an outcome.
DarwinsToffees
·il y a 10 mois·discuss
This is very encouraging, but will take a long time to get to any type of usable treatment because these cells are literally made to evade the immune system they run a whole bunch of other risks. Also cell therapies right now are one of the weakest markets in Biotechs due to the level of costs to develop. This is slightly different since it's Allogenic, but the market seems not very invested in cell therapy.
DarwinsToffees
·il y a 10 mois·discuss
To be honest I didn't even know they had this.