I'm not optimistic. A simple loop summing numbers in a list is at least 30 times slower than PyPy, GraalPy, and Node.js, regardless of whether the JIT is enabled or not. I've watched and read everything there is to know about Python performance, and I'm afraid that without Python 4 (which won't be coming), there won't be much to gain. PyPy is great, but I'm afraid it won't be supported for long, and I wouldn't bet on it for a serious project. I migrated my own project to JS and I am rather satisfied (certainly with the performance).