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comova

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Ask HN: Could an LLM predict someone's speech 5 seconds ahead in realtime?

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Drinking alcohol reduces the body's natural GLP-1 activity by 34%

recursiveadaptation.com
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comments

comova
·l’année dernière·discuss
I believe this is to improve performance by shortening the context window for long thinking processes. I don't think this is referring to real-time summarizing for the users' sake.
comova
·il y a 2 ans·discuss
For example, in the recent Phase 2b CB1 agonist for cannabis user disorder from AELIS, the FDA required a standard of efficacy of an 80% reduction in use. The trial failed for unrelated reasons, but many researchers in the field have expressed frustration that this requirement, a reduction far beyond what will improve a patient’s health, sends a negative signal to other companies interested in advancing effective addiction treatments.
comova
·il y a 2 ans·discuss
I’ve lost 60 pounds and my health has improved considerably. I was overeating out of boredom and stress. I’ve been able to reduce my blood pressure medication. My blood sugar is much more controlled. I started riding a recumbent bike for an hour and a half a day due to concerns of losing muscle along with fat.
comova
·il y a 2 ans·discuss
yes
comova
·il y a 2 ans·discuss
A new, large retrospective study of patient health records shows a 40% drop in opioid overdoses and a 50% drop in cases of alcohol intoxication among people who received GLP-1RAs (typically for diabetes or obesity).
comova
·il y a 2 ans·discuss
And if you haven't asked a friend who's on one, taking a GLP-1 medication reduces drinking by about 50%:

https://recursiveadaptation.com/p/first-ever-randomized-tria...
comova
·il y a 2 ans·discuss
"These findings provide compelling evidence that acute alcohol consumption decreases GLP-1, a satiation signal, elucidating alcohol's 'apéritif' effect." This could increase hunger and cravings (including for more alcohol).
comova
·il y a 2 ans·discuss
“I’m now offering GLP-1s to nearly all my substance use disorder patients.”
comova
·il y a 2 ans·discuss
This shape, known since at least Plato's time and named by Kepler, has fascinated thinkers from Archimedes to Buckminster Fuller. As its name implies, it's somewhere between a cube and an octahedron, taking six and eight of its 14 sides from each of those respectively. It's rounder than either of those shapes though, making it a much better vessel for salt, olives, or weed.
comova
·il y a 2 ans·discuss
"Because the pharma companies with approved GLP-1s do not pursue addiction treatment, a large scale trial and FDA indication will not happen on its own. Without a strategic public effort along these lines, we may be waiting 10-15 years before a GLP-1 indication becomes available.

If we are successful in launching large-scale studies, this will be an unprecedented non-profit scientific endeavor, filling the gap between public research agencies and pharma, and collaborating with both along the way. We’re excited."