tsc filename.ts
And you will have a javascript file that you can run in a browser. No configuration files needed, just need to install the typescript compiler. Sure if you need more complicated things. You will need a more complicated setup. But it is no worse (and in someways better) than most of the ecosystem.
IIRC He said that when Apple got the cleartype patent (due to the Apple/Microsoft cross patent agreement that happened in the late 90s), they kinda messed up the implementation of cleartype and Windows actually implements it correctly and Mac OS X (now Mac OS) doesn't.
So I find this somewhat amusing.