While the serotonin used in your gut doesn’t directly impact the brain, it does impact the enteric nervous system which communicates via the vagus nerve to your brain. So I don’t think it’s correct to say this doesn’t (or couldn’t) impact your mood (and indeed murine experiments demonstrate it does).
Or perhaps there are significant links demonstrated in murine models of the
multi-directional relationship of the gut-brain-immune axis, and that traditional models of disease are not sufficient to elucidate this?
Some people really do have mast cell issues, but everyone and their dog thinks they have MCAS these days and it's questionable in my opinion. Often a diagnosis will be based on whether any of the MCAS-drugs work (rather than testing which is very problematic for MCAS). But as you see in the linked paper famotidine was effective in mice genetically engineered without mast cells, so at least in that instance it's not a mast cell issue.
The tricky thing with increasing butyrate production is that everyone's gut dysbiosis is different - and therefore, a prebiotic that works for one person may make someone else's condition worse. For example, I have big blooms in my Prevotella Copri population which would consume Inulin and make my butyrate production worse - but in people without a Prevotella Copri overgrowth, Inulin would improve their butyrate production.
I would look into 16S microbiome testing (I use Biomesight) and use that as a guide, as well as slowly trialing interventions and monitoring symptoms. None of this is perfect and you kinda have to be on the bleeding edge of science/alternative medicine to figure things out.
Famotidine an old school H2 antihistamine used for acid reflux (pre PPIs), was found to have an additional mechanism of action via activation of the vagus nerve to inhibit pro-inflammatory cytokines in covid (via alpha 7 nicotinic acetylcholine receptor (α7nAChR) signal transduction - https://molmed.biomedcentral.com/articles/10.1186/s10020-022...).
It has also been used quite extensively to combat post-covid neuropsychiatric symptoms.
I think the link here is that increased LPS/endotoxin production by your microbiota can induce acid reflux, cause neuroinflammation and psychiatric symptoms. Low acid production itself can result in a more inflammatory microbiome further exacerbating the problem. Long term fix would be working on the migrating motor complex, improve motility/gastric emptying and rebalance the microbiome by reducing gram-negative bacteria/pathobionts and increasing butyrate production via selective feeding. [I'm not a doctor, this is just the direction I've been working on things myself]
How have you determined that the excess deaths are due to "covid restrictions" and not for example, long term sequelae of covid itself or other factors?
To get to the point of re-joining will take a long time with plenty of time for governments and minds in Europe to change.
Ultimately the EU is stronger with the UK as a member, and I’m sure if it’s willing to pay a high enough price it will be let back in (metrication, no-rebate, the euro etc).
I've used SSP and let's just say I think it's nothing short of revolutionary. It seems to be completely changing how my brain works and how quickly it gets activated (in the sense of what state it is in).
Try to be born vaginally rather than c-section (might be too late for that!), avoid antibiotics unless you absolutely need them, polyphenol-rich whole food diet with diverse fruits and vegetables, lots of fibre and resistant starch and fermented foods. Buy organic if possible.
My guess: Environmental toxins, antibiotic use and poor diet leading to loss of microbiome diversity/dysbiosis and consequential disruption to the body’s homeostatic processes.
Yes - totally the opposite. In fact, I think the issue with Angular is that they've not finished the work to make Angular RX-everywhere (for example, reactive components need to be manually plugged into Subjects at the moment).
With RxJS you should use it everywhere (observing state, observing component inputs, side effects etc). It's when you use it half-heartedly that you get problems with merging different programming paradigms.
The biggest issue with RxJS that we've found is that some devs have a super hard time getting to grips with the paradigm, and if your project is mostly those types of people, it will end up a disaster.
To add to my comment, this explains why SSRIs take some time to work - it's the signalling through the vagus nerve that takes time to impact the brain. Other compounds such as curcumin and famotidine (H2 antihsitamine) have also been found to work via this mechanism. For many many years scientists had dismissed curcumin as having no effect because it's not bioavailable - recent research has shown that it doesn't need to be if it directly activates your nervous system! There's a lot more research that needs to be done here, and I think promising therapeutics for impacting brain function are coming our way as researchers learn more.
If you consider the brain a state machine, inputs from the nerves - through gut-brain axis, through your eyes and ears (socialising, environmental cues, sounds of safety vs sounds of threat), through your skin (touch) etc all impact the state. This state can range from safety to fight-or-flight (anxiety) to shutdown (depression). This is hugely simplified (for example neuroinflammation, endotoxins/LPS etc can impact this also) but I've found it very useful for regulating my own state and understanding why I feel happy, agitated, low etc.
So they also seem to be effective via the enteric nervous system!