I don't think that exculpates the Trump administration for its arbitrary and capricious use of export controls, an ill-suited legal mechanism, without reasonable process or justification - thereby forcing Anthropic to scramble.
That's one of the reasons. The primary reason is THC is a partial CB1 receptor agonist - CB1 is abundant in the central and peripheral nervous systems - so it increases sympathetic nervous system activity and norepinephrine, both of which raise heart rate independent of vasodilation.
They didn't find that cannabis use leads to cardiovascular disease. They found a strong association between cannabis use and cardiovascular disease in a very large study. Correlation isn't causation. The study itself acknowledges that. That doesn't mean it's an invalid or useless study that didn't add to the body of scientific knowledge and evidence about the relationship between cannabis use and cardiovascular disease - I think we agree there. That's how science works. Observational studies do not definitively prove causality.
After reading the study, should we update our posterior on the hypothesis that cannabis use causes cardiovascular disease to nudge it in the direction that it does? Yes - that's just Bayes' theorem. Does the probability go to 95%+? No, of course not; I'm not claiming otherwise. It's still useful research.
Also, worth noting that MI risk spikes several-fold within the first hour after cannabis use (and that's not caused by cocaine).
That's not really a fair standard by which to judge the study, abstract or not. The dosing mechanism information was not present in the underlying dataset available to them:
> This retrospective cohort study utilized the TriNetX health research network, which aggregates deidentified electronic medical records from health care organizations worldwide.
> 1) The cannabis-user group with cannabis use diagnoses (International Classification of Diseases, 10th Revision: F12.1, F12.9, F12.90).
You can't expect them to work miracles and come up with data they didn't have. They produced a valuable piece of research furthering our understanding of the cardiovascular risks of cannabis use based on a very large existing dataset that was available to them.
Of course they would love to be able to answer the question of whether smoking is worse for your heart than edibles and so on, and they stated they would like to do this in a future study. But that costs time and money to create an entirely new dataset, and you know what funding for science is like these days.
There's plenty of other evidence in the literature on the cardiovascular effects of THC if you want to see what our current understanding is there. TL;DR: smoking is worse than vaping or edibles; myocardial infarction risk spikes within the first few hours of using cannabis; but the risks are not limited to inhalation because THC itself has physiological effects that raise cardiovascular risk factors (increased heart rate, endothelial dysfunction, platelet activation raising clotting risk, inflammation and oxidative stress, etc.).
This article refers to two studies. The retrospective study of 4.6 million people did account for tobacco use.
> The findings are from a retrospective study of over 4.6 million people published in JACC Advances and a meta-analysis of 12 previously published studies being presented at the American College of Cardiology's Annual Scientific Session (ACC.25).
> Kamel and his team conducted the retrospective study using data from TriNetX, a global health research network that provides access to electronic medical records. Their findings indicate that over an average follow-up of over three years, cannabis users had more than a sixfold increased risk of heart attack, fourfold increased risk of ischemic stroke, twofold increased risk of heart failure and threefold increased risk of cardiovascular death, heart attack or stroke. All study participants were younger than age 50 and free of significant cardiovascular comorbidities at baseline, with blood pressure and low-density lipoprotein (LDL) cholesterol levels within a healthy range and no diabetes, tobacco use or prior coronary artery disease.
"I've heard a lot of questions about Fable's availability on subscription plans.
While it will come off subscriptions after July 7th, we aim to restore Fable as a standard part of our subscriptions as soon as capacity allows, as we mentioned in our original blog post."
"For Pro, Max, Team, and select Enterprise plans, Fable 5 will be included for up to 50% of weekly usage limits through July 7, after which it will be available via usage credits."
Yes, if you're savvy enough to know to stick to sunscreens that contain zinc oxide as the only ingredient (I don't think most people are), and don't mind looking like a ghost (the white cast) or getting white marks on your clothes, this is a safe and effective option. If you aren't checking the ingredients lists carefully, like most people aren't, and you don't know that most sunscreen-containing products in the US are hormone disruptors, like most people don't, your health is at risk.
BEMT is the first new ingredient allowed by the FDA since the 1990s. It's meaningful but a very narrow decision. The FDA still has not approved any of the following sunscreens that have been widely used outside of the US, in some cases for decades:
If you live in the US, you are quite literally taking a risk with your health using US-made sunscreens. Luckily brands like Beauty of Joseon (Korean) and many others are readily available through sites like Yamibuy.
Within the US, I would say New York, but the taxes are of course no better there than California. Both FL and TX are still growing fast in population (not sure about Austin or tech specifically though) while CA is experiencing net outflows.
Outside of the US, London (+5.4% annual growth in 2026) is probably the biggest concentration, with high quality inexpensive talent available from universities both within London (ICL, UCL, King's etc.) and from the nearby Oxford and Cambridge universities. Much of that talent used to flow to the US, but given the current administration and restrictions on H-1B, may now be more likely to stay in the UK.
Singapore (+26.7%) is growing very fast and is now in the top 10.