In those situations, the more productive option to course-correct is to talk to the change author in a meeting/chat instead of just volleying off a tsunami of comments about various minutiae in the change IMO.
> When you receive a review with a hundred comments, it’s very hard to engage with that review on anything other than a trivial level.
Wow, that seems crazy. I can only hope I never have to work with somebody who thinks it is productive to leave that many comments on a change -- I genuinely cannot imagine any change that could ever require that.