"Doses are at the high end of those administered in clinical practice, reflecting typical doses in nonmedical settings, where use tends to be occasional rather than chronic."
I think the point is to highlight that using these drugs as a one-off is not effective. To the surprise of no-one, poorly dosed medications perform poorly.
There's going to be very little crossover between 1) people who need to see this paper, and 2) people who are the types to read papers on dosage efficacy.
Maybe 'unfit', 'ill-suited' or 'irrelevant' would be more suitable.
I love Cal's writing, but I feel like it's really going against his mantra (of Deep Work) to be making posts like this that try to pluck meaning out of nothing for the sake of marketing.