robbiep

4,831 karmajoined 14 वर्ष पहले

Emergency Doctor Founder

comments

7 दिन पहलेdiscuss

You know what already detects breast cancer? Mammograms followed by ultrasound.

We have screening programs for a reason. We know the sensitivity and specificity of these. They are widely available in any rich country that doesn’t treat its citizens like shit. There will absolutely be better stuff out there as we progress, with better sensitivity/specificity and lower harm (everything medical has some harm quotient) but I have a hard time wrapping my head around how they will best physics to provide better than state of the art today with this technology (and bow they will beat availability of current screening systems)

13 दिन पहलेdiscuss

‘Catfishing is fine’

16 दिन पहलेdiscuss

My impression isn’t that they are trying to improve CTE imaging (did it say that in the article?!) but somehow approach the resolution of being able to run the blood flow data through a black box so they can demonstrate what the occipital cortex is processing. I mean, that’s literally the first part of the article?

Can MRI/CT demonstrate CTE.

Well, like a lot of things which as alzheimers, that is still a pathological diagnosis for the most part, to the best of my knowledge (not post mortem scanning but out some brain tissue on a slide), but this belies the general fact that getting the tissue diagnosis is really not that important to anyone except a pedant, because yes MRI will show changes in grey/white matter differentiation and size compared to age and sex weighted cohort; and CT will show similar; and in fact it is the history and examination that practically matter to both the patients and their family.

So while it’s nice to have a totally 100% bulletproof ‘diagnosis’ for labelling purposes, practically on history and exam it’s not going to change how they are managed or what they and their family do say to day; given that both CTE and basically any of the dementias don’t have any treatment associated with them, and the current neuro imaging we have can deliver much higher resolution than what this is promising anyway (I mean even CT angio, and it’s not using ‘advanced imaging processes’ to create data out of noise)

17 दिन पहलेdiscuss

The methods described in the main article refer specifically to neurovascular imaging. In order to have a higher resolution, they’re making use of microbubbles (which need to be prepared and injected just prior to imaging).

There is no world where vascular imaging with a methodology like this is better than what I can do today in a GP clinic with a handheld GE or butterfly (or similar) US probe for anything that matters:

- for dvts and thrombus I can already image them

- if it’s in the brain the last thing that is useful for you to do is fuck around in a small clinic when you should be getting to a major tertiary centre as soon as possible

2 माह पहलेdiscuss

Some Microsoft setups ONLY allow Authenticator - can’t use 1pass etc. I have recently fallen into this pit

6 माह पहलेdiscuss

I am a huge Tchaikovsky fan, mostly as I love his hard sci fi and incredible world building. I normally shy away from any fantasy but his city of last chances trilogy (now turning into a quadrilogy/on its was to 5??) is one of the absurdist Pythonesque and actually funny series I’ve read in years (although the first one is legitimately hard to parse/read given the style). Still, the juice is worth the squeeze and the second in the series I found hilarious.

7 माह पहलेdiscuss

I got a student subscription to cursor and after giving it a good 6 hours I’ve abandoned it.

I extremely dislike the way it goes forth and bolts. I don’t trust these tools enough to just point it in the direction and say go, I like to be a human in the loop. Perhaps the use case I was working on then was difficult (quite old react native library upgrade across a medium sized codebase) but I eventually cracked this on Claude; cursor in both entropic and Gemini left me with an absolute mess.

Even repeatedly asking the prompt to keep me in the loop it kept on just running haywire.

10 माह पहलेdiscuss

The difficulty is stopping when control of the organism is actually achieved, not just when you ‘feel better’. Most people are totally unable to make this judgement

10 माह पहलेdiscuss

Huntingtons is not unique but certainly notable because it is caused by repeat sequences and therefore uniquely suited to mRNA silencing in this manner. There are very few other progressive (and I presume you also mean neurological) conditions, but also applied to the rest of the body, where this is the pathophysiology. For example, currently there is no immediate expansion of this to ie Parkinson’s (different pathophysiological basis) Lewy body (although maybe?) alzheimers (again possibly depending on whether it is tau, amyloid beta or simply ‘type 3 diabetes’) and nothing whatsoever for vascular dementia or ALS

10 माह पहलेdiscuss

Have a read (rather than guessing) - it’s fascinating! Your other reply has a good insight but on more of a related topic but the primary reason this exists is for error correction. So approx one third of single nucleotide mutations have no change on the expression of the DNA or protein. And some of those that do change the amino acid are actually conservative; ie changing a basic amino acid to another basic amino acid which may still end up folding in the same way

पिछला वर्षdiscuss

I haven’t had an issue with Aussie cards?

But I still hit limits, I use Claudemind with jetbrains stuff and there is a max of input tokens (j believe), I am ‘tier 2’ but doesn’t look like I can go past this without an enterprise agreement

पिछला वर्षdiscuss

You used a shit example with the Woolies CEO - he was immediately absolutely reamed on every medium because of the sheer transparency of the stunt - him in his shirt with name tag in an empty shop and then chucking a wobbly when he didn’t like the questions. He blew it and he looked like a tool.

I find the obsession we have with saying we have a problem with success absolutely does not translate to my lived experience here. I see it on the national stage where the moment someone fucks up everyone piles on, but usually they’ve been on a path to being a flog for a long time anyway and they need, at the very least, a reality check.

Think how much better Elon musk’s headspace could be if one person in his circle had told him ‘you are mortal’ regularly along his journey of multiple triumphs

3 वर्ष पहलेdiscuss

You need to work on your comprehension

3 वर्ष पहलेdiscuss

I don’t get this HomePod hate. I have the big (old gen) and small one, and they rock. We’re in allocated housing at the moment for my fiancées work and they have a shitty tv. I wouldn’t be able to hear the thing if it wasn’t playing through my HomePod. And that’s before the benefits of it as a speaker

3 वर्ष पहलेdiscuss

Please do a show HN when you’re close!

4 वर्ष पहलेdiscuss

For all mankind.

4 वर्ष पहलेdiscuss

You’ve missed out a lot of numbers here. Soyuz is a bad example because it doesn’t matter how ‘cheap’ it is, it isn’t reusable.

If they can built a second stage for $13m, $2m for fuel and refurb (musk has previously said marginal cost for a relaunch is $15m) you’ve got marginal costs per terminal assuming 50 per launch of $300k, and terminals are somewhere between 250-500k (Shotwell said in 2019 they were below 500k ‘already’).

So I’m going to go with 600k cost to orbit for a single satellite.

There’s ~2,400 in orbit currently, so rough capital outlay so far is $1.44Bn

Income at 528M means they’re closing hard on some sort of model but yea that 2-4x figure looks good-ish

5 वर्ष पहलेdiscuss

You have misunderstood the point I am trying to make. I’m aware he has said and been responsible for things that are pretty distasteful today, and potentially by a bunch of people in his day. That doesn’t nullify his contribution to history, it just makes him another flawed human

5 वर्ष पहलेdiscuss

I didn’t intend to compare Churchill to Jobs or the others in terms of achievements, it was more a comment on criticism I have seen of him in the last year which nullifies all of his accomplishments on the basis of racist comments, which, however unpalatable they may seem today, appear to have ben unfortunately quite in keeping with many of his peers of the day. (I know there were other actions of his that have been criticised as well but let’s just keep it to one example at the moment). So, maybe bad comparison but my intent was illustrative only

5 वर्ष पहलेdiscuss

That works when a company is profitable, which it seems spacex isn’t; and as a musk style startup I (presume, with no evidence) that employees would have some stock. Perhaps.