I click the comments on Reddit to read the full text of the article copied and pasted instead of clicking on the actual link and dealing with the website at the other end.
The entire testing system they describe feels like something I can strive towards too. They make you want their solution because it offers a way of life and thinking and doing like you've never experienced before
The fundamentals of biology are not difficult to grasp. Evolution, DNA -> RNA -> Protein, basic cell signalling, etc are all really easy to grasp with just the tiniest bit of effort. There's really no place for bad analogies, especially such a misleading one.
Sorry to bite your head off, but the reason that I'm passionate about this topic is, and I'm not joking, young earth Creationism. An analogy like the grandparent is something simple to grasp by many people, and then the Creationists can quickly turn around and say, "Well you see how biology is like a computer; somebody built a computer; therefore, God created us in six days, 6000 years ago."
If I had a nickel for every terrible biology to computer processes analogy I saw on this website since joining, I’d probably have enough money to buy a beer. Which is what I feel I need after I see something like this.
Biology does not act like a computer. You cannot reduce biology to an operating system
Honestly the major pain point is that the grad student that wrote the package you need is no longer maintaining it because they’ve graduated. Also the code they wrote sucks, but whatever.
I’m wary of software engineers coming over the bioinformatics because they never have the domain expertise required to make meaningful contributions, and yet many think they know everything.
There is literally a world of biology (text)books that describe the process of evolution and how life came to be. I would recommend finding a syllabus at a local college for a biology class, getting the textbook second hand and then reading it
I am currently in a run playing rapid 5|5 because I found myself consistently running out of time in longer time controls. To me, improving at rapid is making significant progress in my overall chess abilities. I developed a better understanding of end games and openings , so that I can spend more time being careful in the middle game. Recently I noticed that I don’t run out of time in Rapid, and that’s progress to me, regardless of my ELO
I disagree. I think that proteomics is useful without spatial information because it captures a snapshot of cell state, or tissue state rather, of signaling networks via PTMs along with abundance measurements. If you don’t have spatial orientation, you at least have temporal information.
I think increasing the yield of MS2 scans to PSMs specifically by dealing with spectra containing PTMs and chimeric spectra will further enable deeper understanding of cell signaling. Additionally, the targeted analysis of specific sub-proteomes using real time search, using GoDig from the Gygi lab for example, also seems very promising.
Plus, there’s large industry efforts using proteomics as a drug screening tool, an application that doesn’t require spatial resolution of anything. Specifically groups are looking for protein expression knockdown, but it’s not too far a stretch to look for pathway perturbations using real time search and careful controls.
There is nothing that I can think of. The tools of the trade are mass spectrometers, most dominantly right now the high end Orbitraps and the TIMS-TOF. If you’re interested in instrumentation I can send you some resources.
There’s a few good reviews I can send you if you’re interested. Let me know, I’d be happy to connect.
Technically two or three of the silver line buses are also considered to be subway, too. I believe SL1, SL2, and SL3. They’re subway fare and they go underground at some point