I read over it. Interesting. This is something I've been looking into a lot. THe idea to use crisper to alter the dna is good, but the tech isn't perfect and you could in fact program in unintended mutations.
That's why they have to run through a lot of source material before they get the right dna cuts they one, then they isolate those strands and let them proliferate.
You can also have your body clean up the older/damaged cells via autophagy.
Honestly I feel that epigenetics will be the answer to ending aging. Since the body is capable of producing new stem cells all you would have to do is map out the genetic triggers for creating those to replace older cells, and instigating autophagy to clean out the garbage.
For instance, with skin, the "aging" saggy, wrinkly, thinning skin is a result of the body no longer producing enough elastin, and collagen deficiency.
People believe that it's natural for the body to stop elastin production, but I've seen studies where scientists were able to trigger the genes in the dna that're responsible for creating the stuff needed to create elastin.
The cells were perfectly healthy, they simply stopped producing elastin, but when you introduce the trigger compound into the system the genes react to the trigger and you get elastin production.
If you can't pinpoint one gene that goes inactive in the dna that's the sole cause of aging, simply keep replacing damaged genes with fresh ones, and then piecemeal activate any inactive genes necessary to maintain a certain biological age.
So you could have a chronological age of say, 1,000 but your biological age is twenty.
I found this page because I have a google alert set up for "synthetic biology" I have no idea what this website is about honestly.
Exchanging emails or contact info on a public site would be a bit crazy, but I'd love to talk to you about this more. I'm not planning to just theorize about this. I eventually want to get my own lab and put in some work!
That's why they have to run through a lot of source material before they get the right dna cuts they one, then they isolate those strands and let them proliferate.
By the way, there are things that reduce the damage of mutations that happen in cells. Check out xanthohumol. https://www.lifeextension.com/magazine/2018/3/protect-your-h...
You can also have your body clean up the older/damaged cells via autophagy.
Honestly I feel that epigenetics will be the answer to ending aging. Since the body is capable of producing new stem cells all you would have to do is map out the genetic triggers for creating those to replace older cells, and instigating autophagy to clean out the garbage.
For instance, with skin, the "aging" saggy, wrinkly, thinning skin is a result of the body no longer producing enough elastin, and collagen deficiency.
People believe that it's natural for the body to stop elastin production, but I've seen studies where scientists were able to trigger the genes in the dna that're responsible for creating the stuff needed to create elastin.
The cells were perfectly healthy, they simply stopped producing elastin, but when you introduce the trigger compound into the system the genes react to the trigger and you get elastin production.
If you can't pinpoint one gene that goes inactive in the dna that's the sole cause of aging, simply keep replacing damaged genes with fresh ones, and then piecemeal activate any inactive genes necessary to maintain a certain biological age.
So you could have a chronological age of say, 1,000 but your biological age is twenty.
I found this page because I have a google alert set up for "synthetic biology" I have no idea what this website is about honestly.
Rationalist, I'd love to talk to you about this more. send me a dm on linkedin, or facebook. https://www.linkedin.com/in/kendrick-bowman-91b9b716b/ https://www.facebook.com/kendrick.bowman.7
Exchanging emails or contact info on a public site would be a bit crazy, but I'd love to talk to you about this more. I'm not planning to just theorize about this. I eventually want to get my own lab and put in some work!