Glad to see someone pints this out. That’s the main reason I use React + Typescrip. JSX is an extension of javascript and can be fully checked while any template language is a custom invention that it’s hardly toolable.
If you're using a dynamic language, an ORM doesn't provide much. But in C# LINQ has the benefit of being strongly typed, this means your DB schema can be evolved. If you write raw SQL (or Python) and you rename a table/entity or column/property you gonna have a bad time. In C# you can just use a refactoring or, worst case, compile time errors.
Most enterprise web apps use bootstrap, that is quite Standart. But they do it on top of react/angular/grunt/we pack and a zillion npm packages to choose and keep updated. Nothing of this was necessary to make VB6 applications.