I am also a bit skeptical when strong anti-Pharma opinions are expressed, based on personal experience only. Meta-analyses have shown that for severe depression, antidepressants are a first line of attack, only seconded or aided by CBT, but not interchangeable in terms of efficacy. It's kind of stupid to counterargue with yet another personal story, but for me not being able to take SSRIs has proven to be a real problem. I developed a somewhat rare side-effect with both SSRIs and SNRIs, I basically covered up in unexplanable bruises and given the increased risk of internal bleeding, am cut off from this medicine class completely. The only time in my life where I was not crippled by anxiety was on these meds. I continually try relaxation, CBT, DBT and whatnot, but unfortunately I am one of those who does not respond as well to therapy as I do to medication. To be really honest, I am on the other side of the fence: I hope big pharma comes up with something else than benzos and SSRIs for anxiety, so that I can be relieved from the task of living my life spiting anxiety 70% of the day.