Covid-19 Vaccine Makers Unsure If Fine-Tuning Shots for Omicron Is Worthwhile(wsj.com)
wsj.com
Covid-19 Vaccine Makers Unsure If Fine-Tuning Shots for Omicron Is Worthwhile
https://www.wsj.com/articles/covid-19-vaccine-makers-are-unsure-if-fine-tuning-shots-for-omicron-is-worthwhile-11639054806
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also known as the antigenic sin
https://en.m.wikipedia.org/wiki/Original_antigenic_sin
https://en.m.wikipedia.org/wiki/Original_antigenic_sin
Key quote: "Evidence is building that this phenomenon, also known as immune imprinting, is at work in Covid-19. The implication: Boosting with an Omicron-specific vaccine might only reawaken earlier immune responses, whether they were spurred by vaccination or infection. In other words, an Omicron-specific vaccine may have no advantage over simply boosting with the original vaccines."