Anarchists making their own medicine (2018)(vice.com)
vice.com
Anarchists making their own medicine (2018)
https://www.vice.com/en/article/43pngb/how-to-make-your-own-medicine-four-thieves-vinegar-collective
220 comments
Those costs aren't all borne by corporations, just the profits. The cost is the cost of public schooling of the children that invent these things, the invention and development of internet partially funded by DARPA that allows quickly conveying scientific information these companies use, the millinia of scientific research that precedes the invention.
The corporation then benefits from regulatory capture, and insanely high regulatory barriers to lock away less capitalized competitors from introducing their own unique drugs. Those who can afford the insane regulatory costs then can squeeze consumers dry.
Open up a maximally free market for pharmaceuticals and watch these snakes die. If I want to GC/MS some shit I bought out of some guys basement to check purity myself then let me.
The corporation then benefits from regulatory capture, and insanely high regulatory barriers to lock away less capitalized competitors from introducing their own unique drugs. Those who can afford the insane regulatory costs then can squeeze consumers dry.
Open up a maximally free market for pharmaceuticals and watch these snakes die. If I want to GC/MS some shit I bought out of some guys basement to check purity myself then let me.
Even in academia, where most research originates and matures before being sold to corporations, the vast majority of research is tax-payer funded. I wholeheartedly agree with you stance. It's unsurprising that these regulatory barriers keep all but the wealthiest corporations out of the market considering that big pharma and insurance account for significant share the donor-base of most politicians in the United States.
Tax base funds the work, donor base collects the rewards.
Tax base funds the work, donor base collects the rewards.
Most of the R&D done to make drugs isn't done at universities. They do some initial discovery work and invent entire new categories of drugs, but their overall role in the process of taking a druggable target to market is limited.
Academia gets to keep rewards; universities patent discoveries and license the technology to industry. This made $$$ for Stanford and UC (billions of dollars).
I am sympathetic to the idea that regular joe of US doesn't get enough benefit for their tax payments but actually I think if you look at all the benefits americans get indirectly from living here, it's hard to say for certain that individuals aren't recompensed properly. And, I suppose, if they wanted, many people can buy stock in pharma and enjoy the profits themselves.
Academia gets to keep rewards; universities patent discoveries and license the technology to industry. This made $$$ for Stanford and UC (billions of dollars).
I am sympathetic to the idea that regular joe of US doesn't get enough benefit for their tax payments but actually I think if you look at all the benefits americans get indirectly from living here, it's hard to say for certain that individuals aren't recompensed properly. And, I suppose, if they wanted, many people can buy stock in pharma and enjoy the profits themselves.
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Most of the work is NOT done by academia (i done the academic work myself). I’d say maybe 80% is done by pharma.
You think academia know how to optimize structure? Bulk manufacturer? Organize clinical trials across the globe? Check all the regulatory boxes?
You think academia know how to optimize structure? Bulk manufacturer? Organize clinical trials across the globe? Check all the regulatory boxes?
> You think academia know how to optimize structure? Bulk manufacturer? Organize clinical trials across the globe? Check all the regulatory boxes?
Yes? That is literally where the standards for these things are developed, and constantly tested? For example: the techniques for optimizing structure? Developed in academia. Bulk manufacturing? Reliant on tons of science, engineering, and mathematics, that was developed in academia.
Yes? That is literally where the standards for these things are developed, and constantly tested? For example: the techniques for optimizing structure? Developed in academia. Bulk manufacturing? Reliant on tons of science, engineering, and mathematics, that was developed in academia.
Then you would be mistaken. The proficiency in these tasks and the cost of their execution is borne by Pharma.
Regulatory capture etc is quite real and toxic. But this eat the rich stuff is getting a little out of hand.
Regulatory capture etc is quite real and toxic. But this eat the rich stuff is getting a little out of hand.
I don't understand, where does eat the rich come in here? Academia is usually made up of people who are (relatively) rich and privileged. This has nothing to do with "eat the rich", and everything to do with answering the question: "who bears the costs?", or more appropriately "who pays the bills?".
Answering with the "tax payer" does not now imply that capitalism is evil, and corporations are awful, etc. etc. Rather, it should sober businesses, and remind them that they are part of a system. They need consumers, and consumers need them. Hurting consumers by maintaining unfair prices ultimately comes full circle, and will hurt them, in the long run, even if they profit in the short term.
Of course, our businesses tend not to think about the long term too much, but again, this has nothing to do with "eating the rich", but everything to do with pondering human hubris.
Answering with the "tax payer" does not now imply that capitalism is evil, and corporations are awful, etc. etc. Rather, it should sober businesses, and remind them that they are part of a system. They need consumers, and consumers need them. Hurting consumers by maintaining unfair prices ultimately comes full circle, and will hurt them, in the long run, even if they profit in the short term.
Of course, our businesses tend not to think about the long term too much, but again, this has nothing to do with "eating the rich", but everything to do with pondering human hubris.
QC and regulatory costs are absolutely borne by the corporations that are getting their drugs approved. Those are major expenditures.
I'm not completely arguing with the idea that pharma overprices drugs, but to me, that's a distinct problem from who pays for, and benefits from research and development.
I'm not completely arguing with the idea that pharma overprices drugs, but to me, that's a distinct problem from who pays for, and benefits from research and development.
Terrible argument that implies “nobody makes anything on their own so I have every right to use their work”.
You are free to make your own drugs and “GC/MS some shit”, though you’d just be smarter to buy it outside the US.
You are free to make your own drugs and “GC/MS some shit”, though you’d just be smarter to buy it outside the US.
My argument is terrible. That's why yours is found at the bottom, and mine at the top.
Fuck the thieving snakes claiming it is "their" work when an entirely different 3rd party with no prior contract with the pharma snakes uses their own reagents and chemicals and published or reverse engineered synthetic pathway to produce a substance.
"You are free to make your own drugs." I suppose you are, if you're willing to violate the CSA and FDA/DEA regulations, as my comment pertained to being able to buy drugs _someone else_ made in their basement (although I'd also like to include making your own as well).
Fuck the thieving snakes claiming it is "their" work when an entirely different 3rd party with no prior contract with the pharma snakes uses their own reagents and chemicals and published or reverse engineered synthetic pathway to produce a substance.
"You are free to make your own drugs." I suppose you are, if you're willing to violate the CSA and FDA/DEA regulations, as my comment pertained to being able to buy drugs _someone else_ made in their basement (although I'd also like to include making your own as well).
Our comments are found in the same place because mine is a reply to yours?
You sounds like a very angry anarchist who doesn't really understand R&D works and what kind of effort is required to put into it.
Why would making your own medicines violate the CSA or DEA regulations? You just looking to get high?
You sounds like a very angry anarchist who doesn't really understand R&D works and what kind of effort is required to put into it.
Why would making your own medicines violate the CSA or DEA regulations? You just looking to get high?
>Why would making your own medicines violate the CSA or DEA regulations? You just looking to get high?
Maybe you are unaware. Many medicines are controlled substances. Some people are ill and not just looking to get high, although I think getting high is OK too.
>You sounds like a very angry anarchist
Shit, I am an anarchist. I guess you impugned my character and my statements must be irrelevant. Oh wait, that is ad hominem fallacy.
>who doesn't really understand R&D works and what kind of effort is required to put into it.
I am not angry about R&D. R&D I find to be one of the legitimate components of pharma. It takes so many people to bring a drug to market, I don't think you can really understand the complete picture of how R&D works either. But thank you for the arrogant superiority complex. Are you in R&D or something or why do you think I'm attacking researchers? I've continually said (and perhaps this was better reflected on other comments, apologies if not clear enough on my prior) researchers are important to drug development and that they create real value.
It's the regulatory capture, lobbying, insanely high regulatory barriers that enable many pharma businesses to squash new development from competitors that leaves a bad taste in my mouth, corrupt intermingling with FDA and agencies. Amongst other things, but those are some of the larger ones.
Maybe you are unaware. Many medicines are controlled substances. Some people are ill and not just looking to get high, although I think getting high is OK too.
>You sounds like a very angry anarchist
Shit, I am an anarchist. I guess you impugned my character and my statements must be irrelevant. Oh wait, that is ad hominem fallacy.
>who doesn't really understand R&D works and what kind of effort is required to put into it.
I am not angry about R&D. R&D I find to be one of the legitimate components of pharma. It takes so many people to bring a drug to market, I don't think you can really understand the complete picture of how R&D works either. But thank you for the arrogant superiority complex. Are you in R&D or something or why do you think I'm attacking researchers? I've continually said (and perhaps this was better reflected on other comments, apologies if not clear enough on my prior) researchers are important to drug development and that they create real value.
It's the regulatory capture, lobbying, insanely high regulatory barriers that enable many pharma businesses to squash new development from competitors that leaves a bad taste in my mouth, corrupt intermingling with FDA and agencies. Amongst other things, but those are some of the larger ones.
Just to frame all this a bit better: in Italy epipens cost… wait for it… ZERO - nil - nada.
You have a diagnose of anaphylactic shock risk? You get epipens. Public healthcare pays for it, therefore everyone pays for it with their taxes.
Without a prescription, you can get one for around 75€, which is already considered criminally expensive.
This is true for thousands other products. So please now tell me again how r&d and other costs justify the US prices for the same drugs that are sold profitably Yet way cheaper in other western markets.
This is true for thousands other products. So please now tell me again how r&d and other costs justify the US prices for the same drugs that are sold profitably Yet way cheaper in other western markets.
The direct cost to the consumer is $0 (or lira, or EU, or whatever), but that's because public healthcare negotiated with the power of a volume customer to agree on a fixed price, which is paid for by the government, which is paid for by people's taxes. So what you're doing is spreading the cost of the drug across the population. I had a similar situation when I had kaiser- no out of pocket costs.
As to why drugs are expensive in the US: because the market bears it. Demand is just elastic enough (or inelastic, I always get it backwards) in the US that providers slowly edge prices up. Sometimes they get it wrong for example aduhelm didn't sell so it had a huge price drop recently.
As to why drugs are expensive in the US: because the market bears it. Demand is just elastic enough (or inelastic, I always get it backwards) in the US that providers slowly edge prices up. Sometimes they get it wrong for example aduhelm didn't sell so it had a huge price drop recently.
Drugs are expensive partly because there is not a free market. Drugs that have been off-patent for decades which have 20 generics in other countries have none or only a few here. Anti-parasitics for example, that cost a few cents in Africa are $20 a pill here, for no reason at all, other than regulatory hurdles designed to ensure profit.
Inelastic means less price sensitive i.e. people will pay more. You can kind of think of it like immutable vs mutable.
How much does public healthcare pay for them? That's the crucial question here, not whether the cost is borne by the individual using the good or by the taxpayers as a group. I mean, clearly universal access to healthcare is improved by collectivizing the cost, but it's improved even more by eliminating the cost, or most of it.
I'm confused. Isn't this like saying I bought you lunch with money I took from you last year so your lunch was free?
No. Spreading the costs over millions of taxpayers makes the cost you pay into the system way smaller, plus gives the government a huge contractual power when dealing with pharma companies.
It’s really not that hard to comprehend, but I yet have to find a single American that for some reason doesn’t try to justify or straight up defend the US broken and unequal healthcare system.
Yes, medical cost in the US is out of control. No, the government should not be the provider. That doesn't fix the problem. It just makes new ones. Our government is extremely limited by the Constitution on what they are supposed to do. Unless "providing medical services" is added as a power of government to the Constitution there will continue to be a large, vocal opposition to government healthcare.
Apologies in advance if I’m mistaken, but isn’t your Constitution supposed to protect your right to “life, liberty, and the pursuit of happiness?”
How does one have life and liberty if they have a crushing burden of medical bills?
More simply, how does one have life if the medication needed to save you - is $750 a dose? or $300 an injection (and expiries with no refundable “core charge” whether you use it or not)?
How does one have life and liberty if they have a crushing burden of medical bills?
More simply, how does one have life if the medication needed to save you - is $750 a dose? or $300 an injection (and expiries with no refundable “core charge” whether you use it or not)?
> Apologies in advance if I’m mistaken, but isn’t your Constitution supposed to protect your right to “life, liberty, and the pursuit of happiness?”
You are mistaken. But, that's okay, even many Americans get confused about attributes of the Declaration of Independence vs. the Articles of Confederation vs. the Constitution, and tend to misattribute things from the first two to the last one.
You are mistaken. But, that's okay, even many Americans get confused about attributes of the Declaration of Independence vs. the Articles of Confederation vs. the Constitution, and tend to misattribute things from the first two to the last one.
R&D and quality control provides benefits to patients, and it is critically important to figure out how to reduce the cost of R&D and quality control so we can do a lot more of them. That's what Four Thieves Vinegar and other biohackers are doing.
Regulatory compliance doesn't provide benefits to patients; it's a deadweight loss. As you are presumably aware, to a significant extent, the reason that regulatory compliance is so costly is that, being costly protects established drug companies from competition.
Quality control and initial R&D have nothing to do with why Epi Pens, insulin, or Daraprim are absurdly overpriced in the US. That's purely monopoly rent extraction.
Regulatory compliance doesn't provide benefits to patients; it's a deadweight loss. As you are presumably aware, to a significant extent, the reason that regulatory compliance is so costly is that, being costly protects established drug companies from competition.
Quality control and initial R&D have nothing to do with why Epi Pens, insulin, or Daraprim are absurdly overpriced in the US. That's purely monopoly rent extraction.
Nothing I said above disagrees with the fact that many pharma are indeed doing what you call "monopoly rent extraction". I think all of those drugs are overpriced for non-economic reasons.
Regulatory compliance, for example, with the FDA approval process, isn't a deadweight loss; it's a process that reduces the risk a dangerous drug will be given to the public. It's mostly costly due to incompetence and bureaucracy, not because pharma is evilly plotting to continue to be the only people who can get stuff through the FDA.
If somebody comes up with magical ways to reduce the costs of R&D and QC in pharma, I'm all for it. Just be aware: I've worked around pharma for decades and it will only get more expensive to do any of this. Nobody is going to come in and magically disrupt the business with a new technology pharma didn't think of yet.
Regulatory compliance, for example, with the FDA approval process, isn't a deadweight loss; it's a process that reduces the risk a dangerous drug will be given to the public. It's mostly costly due to incompetence and bureaucracy, not because pharma is evilly plotting to continue to be the only people who can get stuff through the FDA.
If somebody comes up with magical ways to reduce the costs of R&D and QC in pharma, I'm all for it. Just be aware: I've worked around pharma for decades and it will only get more expensive to do any of this. Nobody is going to come in and magically disrupt the business with a new technology pharma didn't think of yet.
Umm, the variance in prices in only very slightly due to quality, like often 5% or 1% or less than 1% of the variance. Please show data accounting for why anti-parasitics that costs 5 cents per dose for a horse or 5 cents per dose in India with 20 high quality generic versions are $50 in the US. Hint. BECAUSE WE DO NOT HAVE A FREE MARKET ON HIGH-QUALITY AND SAFE DRUGS. WE HAVE A PAY TO EXTRACT RENT SYSTEM.
I wish you wouldn't post things like this because, although what you are saying is factually correct, you are saying it in a patronizing and shouting way, which will lead people to associate these insights with acting like an asshole. That makes it harder for them to assimilate them, even when I'm the one explaining them and even if I'm managing not to act like an asshole.
I'm sorry but I used to work in healthcare and we see people suffer because they can't afford the $10 monthly copay on drugs that should cost no more than $10 or $20 for a year supply, like a giant bottle of generic aspirin. The fact that they suffer due to pure exploitation is disturbing.
I understand, and I appreciate your compassion.
Also, the person you were shouting at and saying "Hint" to probably knows about 100 times more than you do about the economics of drug companies.
Sure, if we are talking about on-patent drugs I don't know that much. But if we are talking about off-patent generics there isn't a lot to know. We in the United States have a variety of financial, temporal, regulatory, and competitive barriers that bloat prices, sometimes by a factor of 100, over consumer market price in somewhere like India, or even Mexico.
What reduces the risk that a drug will be dangerous is testing, quality control, replication, and transparency. Regulatory compliance is, at best, a means to those ends, not an end in itself. At worst, and far too often, it's a major obstacle to them.
People don't have to be evilly plotting when their incentives are set up to empower only people who do evil things. Don't forget that, in the US, we're talking about the same regulatory regime that rejected magainin, hasn't brought a new class of antibiotics to market in half a century, has outlawed the flavored vape liquids that help people quit smoking, won't allow you to buy a blood sugar meter until after you have diabetes, prohibited covid testing at the beginning of the pandemic, delayed covid vaccination until five or six months after China was doing mass vaccination, and routinely cuts off opiate addicts cold turkey. It's a Kafkaesque farce, as you know very well, and quite possibly the primary cause of death in the US today.
People don't have to be evilly plotting when their incentives are set up to empower only people who do evil things. Don't forget that, in the US, we're talking about the same regulatory regime that rejected magainin, hasn't brought a new class of antibiotics to market in half a century, has outlawed the flavored vape liquids that help people quit smoking, won't allow you to buy a blood sugar meter until after you have diabetes, prohibited covid testing at the beginning of the pandemic, delayed covid vaccination until five or six months after China was doing mass vaccination, and routinely cuts off opiate addicts cold turkey. It's a Kafkaesque farce, as you know very well, and quite possibly the primary cause of death in the US today.
So, uh, how are we going to ensure that all that testing, QC, and transparency occurs... without some sort of regulatory agency that enforces it? and that agency woudl use compliance (submit this and that form and follow this and that process)... so it would seem that they act as proxies for the value of the things you listed.
In the comment you responded to, I am not taking up the subject of how to achieve testing, replication, QC, and transparency. I am merely pointing out that, to reason clearly about the issue, it is essential to distinguish these goods—genuinely valuable benefits to drug users which should be maximized—from any potential means for achieving them, such as regulatory compliance, which is a deadweight loss to be minimized, even if it is an unavoidable one, as you claim it is.
To do otherwise is similar to measuring the progress of a software project in lines of code, measuring the quality of an airframe design by its weight, or measuring the security provided by the TSA in the number of fingernail trimmers confiscated. It's counting regulatory compliance activities on the wrong side of the ledger.
To do otherwise is similar to measuring the progress of a software project in lines of code, measuring the quality of an airframe design by its weight, or measuring the security provided by the TSA in the number of fingernail trimmers confiscated. It's counting regulatory compliance activities on the wrong side of the ledger.
The people who write the rules take money from the rent extractors and the people who enforce the rules have huge conflicts of interest and go immediately to and from working with the rent extractors. It is a corrupt system of rent extraction that has some quality benefit for the consumer that is extremely inefficient. CRONY-CAPITALISM, MONOPOLIES past patent expiration, and A LACK OF A FREE-MARKET extracts rent from the consumer and destroys a countries' industrial competitiveness as does any form of corruption. Just look up how many generics are available in somewhere like India, or look at drug costs on the Mexican [more] free-market, or just do some research into what is actually happening.
There is a really simple number that tells you what the costs of a company are vs its prices to users. Its called profit. So are the pharama companies profitable?
Yes, most large pharma are very profitable (it's one of the most profitable sectors). As we liked to joke, Roche isn't so much a pharma company as it is a wealthy family that invests in pharma because it's so profitable (until recently there was a very interest structure of family cross-ownership of all the Basel-based pharma firms that was set up for or less for MAD purposes).
I hope we can eventually have self-contained machines that can synthesize many different types of medications. By certifying the machines or testing them thoroughly, you can lessen the worry that people will synthesize the drugs wrong.
I think this is almost possible for a large range of simple, small-molecule drugs.
I think this is almost possible for a large range of simple, small-molecule drugs.
The point of this exercise is that the regulatory capture effectively prevents life saving treatments from reaching the people who need them.
For example, better quality insulin is far more expensive because there's tremendous capture not only in the insulin market but the bioreactors required to make the insulin from bacteria. The process isn't insanely complicated, chemistry-wise, but the fact that only a few can make it and its MUCH better means they can charge more.
Another example is one-off drugs for rare but potentially curable conditions. They are often so expensive that they're pulled from the market because 1% of 1% of the population needs them and you can't use that to drive revenue.
3D printing took off precisely because of the LACK of regulatory capture. Imagine you had an FDA synthesizer that could make something common and simple like blood pressure medication for fractional cents on the dollar. You wouldn't be able to find the plans for this like you could for a 3D printed gun, for example, because the technology requires actual expertise to use. So you'd likely be left buying it from some biotech firm who will happily charge a price equivalent to a lifetime supply of all the drugs it can produce. You once again reach the affordability problem. Not because the technology is that far out of reach or so esoteric, but to be able to even get the device into the people's homes who need it you would need to find centuries of deeply entrenched and well capitalized special interests. Pharma would rather you die from something preventable than leave a single penny uncollected. Normally this would be considered hyperbole but in this case it's absolutely, verifiably true.
You can be certain if any DIY "3d molecule printer" ever took off there would be heavily armed alphabet soup boys at the DEA ready to kill whoever to keep the interests of big pharma in power.
For example, better quality insulin is far more expensive because there's tremendous capture not only in the insulin market but the bioreactors required to make the insulin from bacteria. The process isn't insanely complicated, chemistry-wise, but the fact that only a few can make it and its MUCH better means they can charge more.
Another example is one-off drugs for rare but potentially curable conditions. They are often so expensive that they're pulled from the market because 1% of 1% of the population needs them and you can't use that to drive revenue.
3D printing took off precisely because of the LACK of regulatory capture. Imagine you had an FDA synthesizer that could make something common and simple like blood pressure medication for fractional cents on the dollar. You wouldn't be able to find the plans for this like you could for a 3D printed gun, for example, because the technology requires actual expertise to use. So you'd likely be left buying it from some biotech firm who will happily charge a price equivalent to a lifetime supply of all the drugs it can produce. You once again reach the affordability problem. Not because the technology is that far out of reach or so esoteric, but to be able to even get the device into the people's homes who need it you would need to find centuries of deeply entrenched and well capitalized special interests. Pharma would rather you die from something preventable than leave a single penny uncollected. Normally this would be considered hyperbole but in this case it's absolutely, verifiably true.
You can be certain if any DIY "3d molecule printer" ever took off there would be heavily armed alphabet soup boys at the DEA ready to kill whoever to keep the interests of big pharma in power.
That could never be as efficient or as safe as making huge industrial-size batches.
Citation needed. You often get far better purity with lab scale synthesis, but the cost per mole is OOM higher.
I remember a few years ago, someone made a suggestion, that, because a lot of these overpriced drugs are paid by insurance companies.
So why don't insurance companies contract an independent lab to make their own medicine instead of paying ridiculously high prices for out-of-patent medicine? Of course, it would be a proper lab, with certifications and quality control, not some guy's basement, so it would be expensive, but on the other hand, the alternative is also way too expensive.
So why don't insurance companies contract an independent lab to make their own medicine instead of paying ridiculously high prices for out-of-patent medicine? Of course, it would be a proper lab, with certifications and quality control, not some guy's basement, so it would be expensive, but on the other hand, the alternative is also way too expensive.
The big insurance companies own, at least in part, the large pharmacies. Manufacturing drugs adds a risk bundle of appeasing regulators and liability for adverse effects from the drugs made.
Insurance companies are happy to be the buyer and seller as that is plenty profitable without the legal risk.
Insurance companies are happy to be the buyer and seller as that is plenty profitable without the legal risk.
It all sounded nice and good until I read the part about the microlab using spare bicycle tubing, and wanting drug dealers to cut heroin with PrEP meds...what can possibly go wrong with cutting everh dose of heroin with an HIV drug made through bicycle plastic tubing?
Not to mention that PrEP is not made to be injected, blood clots and other issues can appear. These natural medicine people are dangerous.
Your information may be out of date. Wiki[1] says "In December 2021, the FDA approved Apretude, which is an injectable form of PrEP", and Apretude seems to be a brand name for cabotegravir, which is the chemical named in the OP. (The capital letters in PrEP make me think it's a specific drug, but apparently people use it to mean several different drugs with similar purposes.)
[1] https://en.wikipedia.org/wiki/Pre-exposure_prophylaxis
[1] https://en.wikipedia.org/wiki/Pre-exposure_prophylaxis
PrEP is a generic term for a medication that you take before the act, yeah. I was mostly refering to Truvada here which is the one that gets most passed around.
And how does the risk of that compare against:
- the risks from whatever else the heroin is cut with (fentanyl?)
- the risk of getting HIV
- the risks of taking heroin in the first place
The others aren't crimes against humanity unlike willful and deliberate human experimentation on unwitting and unconsenting human subjects.
Er... Is the anti-HIV stuff human experimentation? Are these guys collecting data? Seems like they're taking a drug that's known to help (incidentally it got FDA-approved in December 2021, based on trials whose results were announced in November 2020; I'm sure the FDA had excellent reasons for that delay) and sticking it where they think it'll help those who take it. This is compared to drug dealers who take a drug known to be harmful (fentanyl) and stick it where they think it'll substitute for more expensive ingredients and will keep the customers coming.
Are you really saying that the former is a crime against humanity and the latter isn't?
Are you really saying that the former is a crime against humanity and the latter isn't?
Yeah, that tubing sounds like it could be pretty bad for your health
Not an Anachist but I wonder how much of the danger here is due to the law. Ideally they would simply be selling the epipencils and doing testing etc but there is no way they would be able to do this. So instead the best they can do is create DIY kits.
I wonder how far they can legally push the DIY kit. Can they ship you supplies with the kit? Can they ship you expresso-like packs for your DIY machine?
I wonder how far they can legally push the DIY kit. Can they ship you supplies with the kit? Can they ship you expresso-like packs for your DIY machine?
This reminds me of vaping in Australia: since vaping liquids containing nicotine are illegal, people make their own liquid by mixing nicotine-free vaping liquids (which are legal) with nicotine extracted from products such as Nicorette (which are also legal) - unfortunately some just go back to cigarettes rather than going through all that trouble.
Luckily, I didn't go back to the stinkies - I never smoked again (I also quit vaping after a while, quitting vaping is not hard because it's not nearly as addictive as ciggies are).
Luckily, I didn't go back to the stinkies - I never smoked again (I also quit vaping after a while, quitting vaping is not hard because it's not nearly as addictive as ciggies are).
They should just call them nutritional supplements so they'll be completely unregulated for either efficacy or safety.
Supplements aren't unregulated. They're treated as food. And I'd bet there's some bit of regulation somewhere that says you can't arbitrarily label a medicine as a supplement.
They're unregulated as a matter of law until there are reports of injury. Unlike food, there's no requirement that the manufacturing adhere to any kind of standard, or that the contents of the supplement match the ingredient list.
Well, if people can even successfully defend against murder charges if they acted in self-defense, to preserve one's own life, why should they not be able to defend against piracy/drug laws if the alternative is death? Some medicines are too expensive, in absence of a proper public health system, and being unable to pay means certain death to some people.
I love this. I have a disorder with no cure, so I will take medication daily for the rest of my life. Worse, it's a controlled substance, so there are all sorts of obstacles thrown in my way arbitrarily. I have to get a new prescription written by my doctor every 3 months, which is a pain in the ass as I have to deal with the bureaucracy. Every time I change jobs, new insurance requires "prior authorization" in addition to a new prescription, so more BS. If I'm traveling abroad, the pharmacy can't ship overseas, and if I get a prescription there, the insurance company won't cover it (and it's more than $1000 / month). Doctors office running a few days behind or not answering faxes (lol) from the pharmacy when I need a new script (happens most of the time I need one)? SOL. Fuck this whole system. I am sick of having to ask permission to get the medicine I need.
> “If you're going to die and you're being denied the medicine that can save you, would you rather break the law and live, or be a good upstanding citizen and a corpse?”
It's obviously better to risk using DIY medicine than to die, and it sounds appealing—mutual aid, neighbors helping neighbors, saving lives with free medicine! But framing it this way significantly misrepresents the issue of for-profit medicine.
People mostly aren't dying because they can't afford life-saving medicine. They are selling their homes, emptying retirement accounts and their kids college funds, going into debt and going bankrupt to pay for life-saving medicine.
These guys have given people a new option. You don't have to go into debt—you could instead choose DIY medicines of dubious quality that could have costly medical consequences for you.
This isn't quite as appealing. It isn't some radical, utopian alternative. It's just how the system works today for poor people in so many areas of life: education, housing, food, medical care, etc. The rich can afford quality, while the poor have to make hard trade-offs and take risks to stretch their dollars.
It's obviously better to risk using DIY medicine than to die, and it sounds appealing—mutual aid, neighbors helping neighbors, saving lives with free medicine! But framing it this way significantly misrepresents the issue of for-profit medicine.
People mostly aren't dying because they can't afford life-saving medicine. They are selling their homes, emptying retirement accounts and their kids college funds, going into debt and going bankrupt to pay for life-saving medicine.
These guys have given people a new option. You don't have to go into debt—you could instead choose DIY medicines of dubious quality that could have costly medical consequences for you.
This isn't quite as appealing. It isn't some radical, utopian alternative. It's just how the system works today for poor people in so many areas of life: education, housing, food, medical care, etc. The rich can afford quality, while the poor have to make hard trade-offs and take risks to stretch their dollars.
> People mostly aren't dying because they can't afford life-saving medicine.
No, people are definitely dying because they can't afford medicine. They're not taking things they need, they're cutting pills in half, they're diluting injections. When they finally die from some acute episode, what got them there is never recorded.
The amount of bullshit I have gone through to get albuterol inhalers (which cost $5 in civilized countries, but used to cost $20 in the US until a consortium of pharma lobbyists churned the patent and got the price up to $80.) I've met people in parking lots to buy out of date medicine in a crumpled brown paper bag. I guarantee that more than one person dies from this every single day, and none of them are recorded any differently than any other asthma death. Not being able to obtain this absurdly cheap to produce medicine that has been available for half a century has put me into intensive care for a week, causing years of medical debt when I was young. I wouldn't have been there if I hadn't been trying to manage without an inhaler.
Daraprim and emergency epinephrine seem like the same type of thing. To be honest, though, I prefer to Meet the Criminals Smuggling Their Own Medicine. For Albuterol, ordering inhalers from India was the real answer.
No, people are definitely dying because they can't afford medicine. They're not taking things they need, they're cutting pills in half, they're diluting injections. When they finally die from some acute episode, what got them there is never recorded.
The amount of bullshit I have gone through to get albuterol inhalers (which cost $5 in civilized countries, but used to cost $20 in the US until a consortium of pharma lobbyists churned the patent and got the price up to $80.) I've met people in parking lots to buy out of date medicine in a crumpled brown paper bag. I guarantee that more than one person dies from this every single day, and none of them are recorded any differently than any other asthma death. Not being able to obtain this absurdly cheap to produce medicine that has been available for half a century has put me into intensive care for a week, causing years of medical debt when I was young. I wouldn't have been there if I hadn't been trying to manage without an inhaler.
Daraprim and emergency epinephrine seem like the same type of thing. To be honest, though, I prefer to Meet the Criminals Smuggling Their Own Medicine. For Albuterol, ordering inhalers from India was the real answer.
It's also worth mentioning that albuterol and similar inhalers used to be an exception to the prohibitions on CFCs (these inhalers an't used in large enough volume to do significant ozone damage), but due to lobbying from the companies that made them, they no longer are.
Why would a company lobby to outlaw its current product? Well, they had patents on "improved" CFC-free versions, allowing them to exclude new entrants from the market.
Why would a company lobby to outlaw its current product? Well, they had patents on "improved" CFC-free versions, allowing them to exclude new entrants from the market.
*aren't used in large enough
That's what I call Metacapitalism.
It is "evergreen" with respect to patented pharmaceuticals.
See https://en.wikipedia.org/wiki/Evergreening
See https://en.wikipedia.org/wiki/Evergreening
Seems odd to call it that as there's little 'capitalism' in it. It's abuse of state regulations rather than market forces.
Agreed, regulators granting your company a monopoly is definitely the opposite of capitalism in a significant sense, even if the company does use wage-labor to produce products whose ownership rests with the owners of the means of production rather than the laborers.
State regulations which are exploitable due to lobbyism which is capital transferred into law generating power. Neo-Feudalism is the final form of unregulated capitalism and has always been it.
Why not just step forward into the Acceptance-Stage of Ideology-Death, instead of being caught with the intellectual trousers down half a century later by ones googling grandkids on a witch hunt?
Why not just step forward into the Acceptance-Stage of Ideology-Death, instead of being caught with the intellectual trousers down half a century later by ones googling grandkids on a witch hunt?
Any characterization of corporations as neofeudal shows a fundamental complete and utter ignorance to what feudalism actually is, in a way that only communists could manage to get so wrong.
Feudalism is a system of rule by networks of oaths and obligations, with military service as the top links. Its practicioners also historically depised merchants and traders from the top and bottom of the hierarchy. It aims for lifetime oaths.
And it is capitalism which cannot accept its ideological death, not communism? The one who proclaimed its inevitability loudly only to die in a single human lifetime, and is preoccupied with 19th century writings and works from unquestioned imperatives rather than experimentation? I think there is some major projection going on here.
Feudalism is a system of rule by networks of oaths and obligations, with military service as the top links. Its practicioners also historically depised merchants and traders from the top and bottom of the hierarchy. It aims for lifetime oaths.
And it is capitalism which cannot accept its ideological death, not communism? The one who proclaimed its inevitability loudly only to die in a single human lifetime, and is preoccupied with 19th century writings and works from unquestioned imperatives rather than experimentation? I think there is some major projection going on here.
Why wouldn't a capitalist corporation choose to lobby the government to bend the rules in their favor if they think that that would give the best ROI? In what version of Capitalism would this not happen? What would remove this incentive structure?
In almost any version of Democracy, an authoritarian politician can choose to run for office on a platform of establishing a dictatorship; in most of them, they can even succeed. That doesn't make the would-be dictator a democrat, and it doesn't make their platform a democratic platform. Similarly, free-market incentives to lobby for government monopolies don't make monopolies capitalistic, because capitalism requires a free market, and monopolies and monopsonies are the opposite of a free market.
Marx called this sort of thing "the internal contradictions of capitalism"; he argued that capitalism was an inherently unstable structure, just as many writers have argued that democracy was inherently unstable. They might be right. But in either case, the possible fact that one system inevitably gives rise to its opposite doesn't make it the same as its opposite.
Marx called this sort of thing "the internal contradictions of capitalism"; he argued that capitalism was an inherently unstable structure, just as many writers have argued that democracy was inherently unstable. They might be right. But in either case, the possible fact that one system inevitably gives rise to its opposite doesn't make it the same as its opposite.
If the premise is that being elected dictator in a free and fair election is undemocratic, it's an authoritarian premise. It presumes that elections are only democratic to the extent that the results agree with some "democratic values" that are separate from the process of having elections.
I agree that the outcomes of democracy can be bad. But I don't believe that bad and undemocratic are synonymous.
I agree that the outcomes of democracy can be bad. But I don't believe that bad and undemocratic are synonymous.
I don't think that the election is undemocratic, no. I think that when the new dictator bans all opposition parties, dissolves the parliament, replaces judges with his allies, and starts having the police shut down newspapers and torture dissidents, that's undemocratic, even if the dictator was democratically elected in the first place, and even if what the dictator is doing is not bad.
You're missing the forest for the trees. This is what Capitalism has always been and always will be due to its incentive structure. If you accept wealth and thus power concentration, you accept market manipulation. The corps won't skip this due to some overarching ideological free-market reason. That's just naive.
I mean, just look at the jungle of regulations and the vast inefficient bureaucracy of the US healthcare system. Those 15k layers of shite can only happen with just as many corps doing everything to either save their profits or trying to get as large a piece of the cake as possible. Public good be damned.
Say if the US gov planned to add $100 per patient in some grant for whatever reason. How much do you think would actually trickle down to the patient? I'd be like nervously donating $100 to a dodgy charity in a corrupt developing nation in the 1960s.
I mean, just look at the jungle of regulations and the vast inefficient bureaucracy of the US healthcare system. Those 15k layers of shite can only happen with just as many corps doing everything to either save their profits or trying to get as large a piece of the cake as possible. Public good be damned.
Say if the US gov planned to add $100 per patient in some grant for whatever reason. How much do you think would actually trickle down to the patient? I'd be like nervously donating $100 to a dodgy charity in a corrupt developing nation in the 1960s.
This is an absolutist fallacy. The fact that no capitalist market has ever been free of market power doesn't mean that they all function just as badly as Brezhnev-era Soviet "markets" or the US healthcare "market". There are actually existing markets that are more capitalist and less capitalist. Markets mostly organized around government-granted monopolies are by definition failing at capitalism.
I think that very little of your hypothetical US$100 would benefit the patient, precisely the opposite of giving US$100 to every consumer in a capitalist market.
I think that very little of your hypothetical US$100 would benefit the patient, precisely the opposite of giving US$100 to every consumer in a capitalist market.
> This is an absolutist fallacy.
Why? You haven't really answered anything with regards to the incentive structure of Capitalism to manipulate the market ASAP. What good "free markets" segments of society even exists today? Restaurants? No, the big chains lobby intensely there as well - less profits if employees earn a living wage.
> I think that very little of your hypothetical US$100 would benefit the patient, precisely the opposite of giving US$100 to every consumer in a capitalist market.
You're missing the point entirely. The comparison if ofc with what would happen if e.g. a Nordic government would do the same thing under a system of universal healthcare.
Why? You haven't really answered anything with regards to the incentive structure of Capitalism to manipulate the market ASAP. What good "free markets" segments of society even exists today? Restaurants? No, the big chains lobby intensely there as well - less profits if employees earn a living wage.
> I think that very little of your hypothetical US$100 would benefit the patient, precisely the opposite of giving US$100 to every consumer in a capitalist market.
You're missing the point entirely. The comparison if ofc with what would happen if e.g. a Nordic government would do the same thing under a system of universal healthcare.
Almost the entire world economy, by value, consists of more competitive markets than US healthcare. Restaurants, yes, but also the rest of retail, energy, agriculture, transportation, mining, metals, automobiles, clothing, shipbuilding, forestry, fishing, custom manufacturing, industrial food processing, scientific instruments, electronics, electrical equipment, and the financial markets. Some of these sectors don't engage in wage-labor production, or aren't dominated by it, and so aren't capitalist, while others are. Actors in all of these sectors, even the noncapitalist ones, engage in lobbying and other forms of anticompetitive behavior, but they generally aren't successful in obtaining monopoly or monopsony power and thus ending capitalism where it exists.
Sectors that lack competitive markets include the military, healthcare in much of the world, banking, and most of telecommunications.
I agree that business (not just capitalism!) creates incentives to destroy free markets, just as politics creates incentives to destroy democracy. When actors succeed in following those incentives, that ends capitalism by eliminating competitive markets, which prevents the price system from being used to allocate resources. Competitive markets and the price system are central characteristics of capitalism; where they fail to exist, what you have is not capitalism, but something else.
At this point I'm starting to repeat myself, because I've already explained this about as clearly as I know how, and you still apparently don't understand.
Sectors that lack competitive markets include the military, healthcare in much of the world, banking, and most of telecommunications.
I agree that business (not just capitalism!) creates incentives to destroy free markets, just as politics creates incentives to destroy democracy. When actors succeed in following those incentives, that ends capitalism by eliminating competitive markets, which prevents the price system from being used to allocate resources. Competitive markets and the price system are central characteristics of capitalism; where they fail to exist, what you have is not capitalism, but something else.
At this point I'm starting to repeat myself, because I've already explained this about as clearly as I know how, and you still apparently don't understand.
That's like saying that a Leninist system stops being Leninist when its vanguard inevitably becomes corrupted, because its vanilla state is - in theory - democratic. But that's ridiculous, each system should be held accountable for the outcome of its incentive system, not just its vanilla state.
> Some of these sectors don't engage in wage-labor production, or aren't dominated by it, and so aren't capitalist, while others are
You seem to be relying on a rather narrow definition of "capitalism".
You seem to be relying on a rather narrow definition of "capitalism".
Thgis is roughly my opionion. I expect companies to get right up against the legal line of what is permitted (to make more profit than their competitors, and be motivated to make the best products) while I expect government to regulate them when their actions would harm the public good.
Only the most naive understanding of capitalism holds those two things as opposites, or mutually exclusive.
lobbying is just utilizing accumulated capital to create favorable conditions. that capital was accumulated by a capitalist firm. that firm's competitive strategy might be aesthetically unappealing to you, but the firm exists in the first place because it can more efficiently utilize resources than any individual could.
capitalism is a way of organizing production with workers being paid a flat rate and owners keeping all additional value added by the workers in exchange. is that not how pharmaceutical companies are arranged?
capitalism is a way of organizing production with workers being paid a flat rate and owners keeping all additional value added by the workers in exchange. is that not how pharmaceutical companies are arranged?
of course, true capitalism has never been tried, but this is what you might call 'actually existing capitalism'
Exactly. This woman in Canada had to sell her house to get a drug that insurance readily pays for in the US. Criminal.
https://www.cbc.ca/news/canada/british-columbia/a-tale-of-2-...
”"It's crazy that I live in Canada, but now I'm looking at having to sell my house for coverage of my medication."
Earlier this week, McLaren walked to her local Shopper's Drug Mart and paid nearly $8,000 for a 21-day supply. On Tuesday she swallowed her first pill, worth $262.40 for just one day of treatment.”
https://www.cbc.ca/news/canada/british-columbia/a-tale-of-2-...
”"It's crazy that I live in Canada, but now I'm looking at having to sell my house for coverage of my medication."
Earlier this week, McLaren walked to her local Shopper's Drug Mart and paid nearly $8,000 for a 21-day supply. On Tuesday she swallowed her first pill, worth $262.40 for just one day of treatment.”
I said mostly. Some die without medicine, but I'd argue that the number is small in comparison with people who are affected economically. By focusing on deaths, you're effectively minimizing the problem.
It's similar to issues like homelessness: 0.15% of the population are on the street, but the number of people affected by housing costs is much larger.
Or police shootings of unarmed black men: 100-200 per year, which pales in comparison with millions of incarcerated black men.
We hear so much about these tiny problems is because political activists have chosen media-centric strategies to influence policy makers. The idea is to use outrage to get on the news, and then bring up the bigger issues. But in practice, policy makers just solve the outrageous problem: body cams for police; more shelters. Then the media goes away.
It's similar to issues like homelessness: 0.15% of the population are on the street, but the number of people affected by housing costs is much larger.
Or police shootings of unarmed black men: 100-200 per year, which pales in comparison with millions of incarcerated black men.
We hear so much about these tiny problems is because political activists have chosen media-centric strategies to influence policy makers. The idea is to use outrage to get on the news, and then bring up the bigger issues. But in practice, policy makers just solve the outrageous problem: body cams for police; more shelters. Then the media goes away.
What if the DIY medicines weren't of dubious quality? What if they were higher quality than the ones that cost US$750 a dose? What if everyone had an analysis machine that could analyze the medicines, DIY or not, to find out what was in them, and the DIY stuff turned out to be purer and more precisely dosed? That's what happened with Linux versus, say, Solaris and Microsoft Windows, and it's what's happening now with programmable insulin pumps.
Also, medical consequences have to get pretty costly before they're more costly than selling your home and emptying your retirement account and your kids' college funds.
Also, medical consequences have to get pretty costly before they're more costly than selling your home and emptying your retirement account and your kids' college funds.
> What if everyone had an analysis machine that could analyze the medicines, DIY or not, to find out what was in them
I can fairly confidently predict this will not happen like it did for software. Chemical analysis has been around a long time and remains difficult for experts to do accurately without context, let alone for a layman. Gas chromatography, for example, requires large and expensive machinery and some idea of what the substance is composed of in order to determine the concentration of analytes.
Reagent testing is cheap, simple, and straightforward, but it is generally only capable of detecting whether or not some class of substances are present above a particular concentration. You cannot use reagent testing to determine "how pure" a medicine is, let alone whether the impurities (which there will assuredly be) are potentially harmful.
As is currently the case for illicit drugs, I imagine there will be an ecosystem to verify that A) the active ingredient is actually present and B) some limited range of problem impurities are not present, but that is a much less stringent form of quality control than pharmaceutical companies perform.
I can fairly confidently predict this will not happen like it did for software. Chemical analysis has been around a long time and remains difficult for experts to do accurately without context, let alone for a layman. Gas chromatography, for example, requires large and expensive machinery and some idea of what the substance is composed of in order to determine the concentration of analytes.
Reagent testing is cheap, simple, and straightforward, but it is generally only capable of detecting whether or not some class of substances are present above a particular concentration. You cannot use reagent testing to determine "how pure" a medicine is, let alone whether the impurities (which there will assuredly be) are potentially harmful.
As is currently the case for illicit drugs, I imagine there will be an ecosystem to verify that A) the active ingredient is actually present and B) some limited range of problem impurities are not present, but that is a much less stringent form of quality control than pharmaceutical companies perform.
Clearly making it happen will require a revolution in manufacturing, which may or may not already be underway, but making it happen for software required decades of continuous revolution in semiconductors and telecommunications.
Some kinds of analysis machinery, like GC, ICP, and DSC or DTA, are probably inherently fairly large; other kinds, like FT-IR, other kinds of spectrometry, TLC, HPLC, other kinds of liquid chromatography, XRF, XRD, and NMR, can be miniaturized and mass-produced. There hasn't been much pressure to do this because bio and chem labs don't care if their spectrophotometer costs US$0.12 or US$12000 or whether it weighs 100 mg or 100 kg; they need one to get their work done, they don't need it to be portable, and they aren't going to lose it because it stays in the lab. But that doesn't mean it can't be done. Even Victorian-era-style reagent testing can be made quantitative in some cases!
Some kinds of analysis machinery, like GC, ICP, and DSC or DTA, are probably inherently fairly large; other kinds, like FT-IR, other kinds of spectrometry, TLC, HPLC, other kinds of liquid chromatography, XRF, XRD, and NMR, can be miniaturized and mass-produced. There hasn't been much pressure to do this because bio and chem labs don't care if their spectrophotometer costs US$0.12 or US$12000 or whether it weighs 100 mg or 100 kg; they need one to get their work done, they don't need it to be portable, and they aren't going to lose it because it stays in the lab. But that doesn't mean it can't be done. Even Victorian-era-style reagent testing can be made quantitative in some cases!
> Some kinds of analysis machinery, like GC, ICP, and DSC or DTA, are probably inherently fairly large; other kinds, like FT-IR, other kinds of spectrometry, TLC, HPLC, other kinds of liquid chromatography, XRF, XRD, and NMR, can be miniaturized and mass-produced
Many of the types of analysis listed here are elemental analysis only, which are useless for trying to identify pharmaceutical analytes or determine their concentration.
Out of all of these, microfluidic liquid chromatography is the least science fiction. There's plenty of literature about it but nobody really "has it working", and the reality is that it's not likely to ever have the same capability as benchtop HPLC.
Many of the types of analysis listed here are elemental analysis only, which are useless for trying to identify pharmaceutical analytes or determine their concentration.
Out of all of these, microfluidic liquid chromatography is the least science fiction. There's plenty of literature about it but nobody really "has it working", and the reality is that it's not likely to ever have the same capability as benchtop HPLC.
> Many of the types of analysis listed here are elemental analysis only, which are useless for trying to identify pharmaceutical analytes or determine their concentration.
That's mostly true, but if a pill has significant amounts of lead, arsenic, and mercury in it, you know something went wrong, and you shouldn't take it. Even XRF might be enough to allow you to safely use lead-based or arsenic-based catalysts in your synthesis.
> Out of all of these, microfluidic liquid chromatography is the least science fiction. There's plenty of literature about it but nobody really "has it working", and the reality is that it's not likely to ever have the same capability as benchtop HPLC.
Thanks! Can you think of any other plausibly miniaturizable general-purpose analysis techniques? Those are just the ones I came up with off the top of my head. I think microfluidic liquid chromatography doesn't actually have to run faster than the bear, just faster than color-changing DanceSafe test kits.
As for science fiction, https://news.ycombinator.com/item?id=29816434 talks a bit about how today's science fiction is tomorrow's old news.
That's mostly true, but if a pill has significant amounts of lead, arsenic, and mercury in it, you know something went wrong, and you shouldn't take it. Even XRF might be enough to allow you to safely use lead-based or arsenic-based catalysts in your synthesis.
> Out of all of these, microfluidic liquid chromatography is the least science fiction. There's plenty of literature about it but nobody really "has it working", and the reality is that it's not likely to ever have the same capability as benchtop HPLC.
Thanks! Can you think of any other plausibly miniaturizable general-purpose analysis techniques? Those are just the ones I came up with off the top of my head. I think microfluidic liquid chromatography doesn't actually have to run faster than the bear, just faster than color-changing DanceSafe test kits.
As for science fiction, https://news.ycombinator.com/item?id=29816434 talks a bit about how today's science fiction is tomorrow's old news.
Probably the 'manufacturing revolution' will be modifying yeast, plants, etc. to produce the chemical compound of interest. Everyone needn't have expensive equipment - testing can be outsourced. Such an effort would need a GPL like agreement to keep people honest, but the technology exists.
Conceivably, but I was a lot more enthusiastic about this possibility 35 years ago before the humans had much experience with it. It turns out DNA is a really shitty programming language for humans. Like, worse than Malbolge.
Miniaturized NMR? can you explain how that would work?
They use rare earth permanent magnets and don't offer the resolution of superconducting magnet NMR, but they are much smaller and cheaper (tens of thousands of dollars, new) than superconducting units or the even older resistive electromagnet NMR units. The first one I saw was from picoSpin, which has since been acquired by Thermo Fisher Scientific. I think that there are multiple vendors now. Here's a current picoSpin unit:
https://www.thermofisher.com/order/catalog/product/912A0913
https://www.thermofisher.com/order/catalog/product/912A0913
An 80MHz desktop NMR in 2022 is hilarious. This owuld be great to put in a research lab or to teach students, but it's not something that could be used in a high volume, high quality pharma testing situation.
(my phd in nmr is from 20 years ago... even then it was hard to justify the expense of nmr machines in structural biology...)
(my phd in nmr is from 20 years ago... even then it was hard to justify the expense of nmr machines in structural biology...)
Benchtop NMR spectrometers already exist (for decades now), and some are already cryogen-free, permitting room-temperature measurements, eliminating the dewar and cryogens which account for a lot of the mass and volume of traditional NMR spectrometers. We now have room-temperature superconductors, which might work to eliminate the bulky, heavy permanent magnets in current benchtop devices, though the pressures required may turn out to be impractical. Beyond that I can handwave at improved electronics and SQUIDs, but I don't really know.
Do you think there are some fundamental obstacles to miniaturizing NMR, and if so, what?
Do you think there are some fundamental obstacles to miniaturizing NMR, and if so, what?
Benchtops are at 60-90 MHz field strengths. That is not really enough to look at more complex molecules, the bigger routine NMR spectrometers are at 400-600 MHz (and there are even larger ones, but those are not used for small molecules that much). And even then those benchtops cost something close to 100k USD, that's quite far from affordable.
The "room temperature" superconductors are not used at room temperature in these cases, they're still cooled down. And so far the only spectrometer I know of where they are used is the still extremely new 1.2 GHz Bruker. And that one is almost certainly somewhere between 10 and 20 million USD. The new superconductors are low temperature superconductors, not room temperature. And even then they still work better at lower temperatures. At best you can remove the liquid helium from the system and use liquid nitrogen only, which is an advantage but still really far from room temperature.
The "room temperature" superconductors are not used at room temperature in these cases, they're still cooled down. And so far the only spectrometer I know of where they are used is the still extremely new 1.2 GHz Bruker. And that one is almost certainly somewhere between 10 and 20 million USD. The new superconductors are low temperature superconductors, not room temperature. And even then they still work better at lower temperatures. At best you can remove the liquid helium from the system and use liquid nitrogen only, which is an advantage but still really far from room temperature.
Thank you for explaining!
Yes, I don't know if the current room-temperature superconductor material (which really is room temperature, 15°C) will ever be useful for this; it was only discovered in 02020, so it is very unlikely that anyone is using it in a product today, even if they find a way to apply the necessary pressure (267 GPa, thus requiring ultrahard anvils). You're probably thinking of something like YBCO, which is "high-temperature" in the sense you're describing, requiring only LN₂, not "room-temperature".
Costs change over time. There was a time when solar panels cost 100k USD, too. A lot of the costs you're describing are NRE; others are costs that can be reduced.
Yes, I don't know if the current room-temperature superconductor material (which really is room temperature, 15°C) will ever be useful for this; it was only discovered in 02020, so it is very unlikely that anyone is using it in a product today, even if they find a way to apply the necessary pressure (267 GPa, thus requiring ultrahard anvils). You're probably thinking of something like YBCO, which is "high-temperature" in the sense you're describing, requiring only LN₂, not "room-temperature".
Costs change over time. There was a time when solar panels cost 100k USD, too. A lot of the costs you're describing are NRE; others are costs that can be reduced.
The new spectrometers are using YBCO, and they are many years beyond schedule. That whole thing turned out to be a lot harder than many people seemed to expect.
The magnets are not the only cost in NMR spectrometers, I think you're seriously understimating the amount of electronics in them. You need to detect very weak signals at several hundreds of MHz, that's not trivial.
The magnets are not the only cost in NMR spectrometers, I think you're seriously understimating the amount of electronics in them. You need to detect very weak signals at several hundreds of MHz, that's not trivial.
How weak are they? Detecting very weak signals (-110 dBm) at hundreds of MHz and even GHz is routinely done by Wi-Fi cards and cellphone radios, and GPS receivers detect signals that are orders of magnitude weaker than that (routinely -150 dBm), but only at tens of MHz. My eyes routinely detect submillilux signals when I look at the stars at night, with an integration time of well under a second; if I'm doing the calculations correctly, that's about -70 or -80 dBm in the 100–1000 THz band. PMTs (including microchannel plates) and SPADs routinely detect optical signals much weaker than that.
To a significant extent you can detect arbitrarily weak signals with coding gain and longer averaging times, although if your benchtop machine already takes ten minutes to give you a result, you probably can't afford to wait more than about 36 dB longer, give you another 18 dB of SNR).
So, I'm not worried about the electronics or the signal processing; there's no such thing as an "amount of electronics". Precision analog equipment is not easy to design, calibrate, and build, but you only need a very small "amount" of it, and it can be mass-produced.
Take resistors. When I was a kid back in the 01980s normal resistors were ±20% carbon composition, which would drift by more than 20% over time or if overvolted, with fiendish temperature coefficients. Now you can't buy a ±20% resistor; most resistors are ±1%, ±0.1% resistors are commonplace, and ±0.01% resistors are easily available for a dollar or two. Precision resistors are now made with an extremum of resistance around room temperature, so the temperature coefficient there is literally zero.
No, what I'm worried about is the physics. I'm not surprised YBCO spectrometers turned out to be a pain in the ass; YBCO is a huge pain in the ass in every possible way. What do you think the physical obstacles are?
To a significant extent you can detect arbitrarily weak signals with coding gain and longer averaging times, although if your benchtop machine already takes ten minutes to give you a result, you probably can't afford to wait more than about 36 dB longer, give you another 18 dB of SNR).
So, I'm not worried about the electronics or the signal processing; there's no such thing as an "amount of electronics". Precision analog equipment is not easy to design, calibrate, and build, but you only need a very small "amount" of it, and it can be mass-produced.
Take resistors. When I was a kid back in the 01980s normal resistors were ±20% carbon composition, which would drift by more than 20% over time or if overvolted, with fiendish temperature coefficients. Now you can't buy a ±20% resistor; most resistors are ±1%, ±0.1% resistors are commonplace, and ±0.01% resistors are easily available for a dollar or two. Precision resistors are now made with an extremum of resistance around room temperature, so the temperature coefficient there is literally zero.
No, what I'm worried about is the physics. I'm not surprised YBCO spectrometers turned out to be a pain in the ass; YBCO is a huge pain in the ass in every possible way. What do you think the physical obstacles are?
The signals are weak, but more importantly, the signals are being detected in a volume wiht a huge magnetic field. You can't even put a digital circuit anywhere in the amplifier. When I worked on the NMR all the monitors in the room were shifted toward the magnet, it would wipe your credit cards, and to adjust the amplifier involved sitting under a multi-ton device twiddling knobs to minimize the impedence.
Think of NMR as bespoke. Like a large luxury liner built for a rich individual. It's not ever going to be a zodiac.
Think of NMR as bespoke. Like a large luxury liner built for a rich individual. It's not ever going to be a zodiac.
As I understand it, the magnetic field doesn't have to be voluminous; it just has to be strong and uniform. It can be arbitrarily small as long as it's large compared to an atom, which is why benchtop NMR machines can exist at all, though they won't ever be truly miniature unless either we can also miniaturize the cryostats and refrigerant supply, or we can find a usable room-temperature superconductor. Am I misunderstanding something? As I said, you know a lot more about this than I do.
benchtop NMR doesn't solve this problem, it's not powerful enough.
If you had improvements to NMR they would actually go first to other things than doing chemical analysis of anarchist drug batches. IE there are other industries that will buy all your machines if they existed.
The real question is why would you EVER use NMR for just about anything? It's really high cost and the total value of the data is lower than just about any other technique. It really only makes sense in research situations.
If you had improvements to NMR they would actually go first to other things than doing chemical analysis of anarchist drug batches. IE there are other industries that will buy all your machines if they existed.
The real question is why would you EVER use NMR for just about anything? It's really high cost and the total value of the data is lower than just about any other technique. It really only makes sense in research situations.
What are the companies, or at least the industries, that would buy all the machines?
Ultimately what everyday people will end up using is whatever is cheap and works well enough. Right now NMR isn't cheap, and neither is FT-IR or XRD, but these things change over time. Benchtop NMR is already good enough for distinguishing between significant classes of contaminants that could be in your purported insulin.
I'm typing this on a 50-gigaflops computer, which is faster than the Cray Y-MP Los Alamos had back in the 01990s, and people routinely buy teraflops video cards now, any one of which is faster than ASCI Option Red, if you remember that. I just drank a mass-produced soft drink out of a can made of aluminum, the metal Napoleon III preferred to gold to exhibit his wealth. Last year Chinese companies brought three covid vaccines to market within six months of the disease's discovery and started mass vaccinations, though most observers had predicted a minimum of 18 months. SpaceX is routinely landing reusable rockets on their tails now, and the world's energy infrastructure is rapidly shifting from fossil fuels to solar.
Things change. Today's science fiction is tomorrow's old news.
Ultimately what everyday people will end up using is whatever is cheap and works well enough. Right now NMR isn't cheap, and neither is FT-IR or XRD, but these things change over time. Benchtop NMR is already good enough for distinguishing between significant classes of contaminants that could be in your purported insulin.
I'm typing this on a 50-gigaflops computer, which is faster than the Cray Y-MP Los Alamos had back in the 01990s, and people routinely buy teraflops video cards now, any one of which is faster than ASCI Option Red, if you remember that. I just drank a mass-produced soft drink out of a can made of aluminum, the metal Napoleon III preferred to gold to exhibit his wealth. Last year Chinese companies brought three covid vaccines to market within six months of the disease's discovery and started mass vaccinations, though most observers had predicted a minimum of 18 months. SpaceX is routinely landing reusable rockets on their tails now, and the world's energy infrastructure is rapidly shifting from fossil fuels to solar.
Things change. Today's science fiction is tomorrow's old news.
Some things change, but to make NMR cost effective would be cheating mother nature. The entire technique is based on producing a strong and homogenous magnetic field that can hold a lot of sample, only to probe the sample with weak RF and listen to its faint echoes.
Industrial diamonds got "cheap" but large ones never did.
Industrial diamonds got "cheap" but large ones never did.
You could be right; certainly you know a great deal more about the subject than I do.
What are the companies, or at least the industries, that would buy all the machines if you could make them much cheaper and/or better?
What are the companies, or at least the industries, that would buy all the machines if you could make them much cheaper and/or better?
You can't really escape the physics here, you need a very strong and very homogeneous magnetic field for NMR and very sensitive electronics to detect the signal. That's not something we can do for cheap right now.
And even beyond that I don't think the area has enough volumen and is competitive enough to produce significantly lower prices. The high-field NMR area is almost a monopoly right now, the benchtops and lower field instruments are somewhat competitive. But even those are in price areas far beyond someone doing synthesis at home.
And even beyond that I don't think the area has enough volumen and is competitive enough to produce significantly lower prices. The high-field NMR area is almost a monopoly right now, the benchtops and lower field instruments are somewhat competitive. But even those are in price areas far beyond someone doing synthesis at home.
As I asked you above, how sensitive do the electronics need to be? How weak is the signal?
I'm not arguing with what you're saying, but GC/MS can be bought for like $100 a sample and it's conceivable a system can be invented where private auditors audit the output of an unregulated pharmaceutical manufacturer in such a way that the QC assurances to the consumer are as good or better as in our current system, with much lower regulatory costs.
In the limit what you are describing is a generic drugmaker.
It's certainly possible to audit drug quality by sending it to labs, and people do that for darknet drugs all the time, but there are still problems:
1) There is no way to use ex-post analysis alone to achieve the kind of QA that pharmaceutical companies do; they have visibility into the entire manufacturing process and process control. Put another way, a sample of a drug cannot be used to verify that the process used to manufacture it is safe.
2) There is no assurance that anything you get in the future is made with the same process.
The only way I see this working, honestly, is for a rogue jurisdiction to offer safe harbor to "generic pirates". The rogue jurisdiction would offer legitimate regulatory oversight in exchange for tax revenue, and the drugs would be smuggled out of the jurisdiction for sale. To some extent this is already the case in grey markets where brand name drugs which are sold for less in other countries get arbitraged/smuggled back to high-cost markets.
It's certainly possible to audit drug quality by sending it to labs, and people do that for darknet drugs all the time, but there are still problems:
1) There is no way to use ex-post analysis alone to achieve the kind of QA that pharmaceutical companies do; they have visibility into the entire manufacturing process and process control. Put another way, a sample of a drug cannot be used to verify that the process used to manufacture it is safe.
2) There is no assurance that anything you get in the future is made with the same process.
The only way I see this working, honestly, is for a rogue jurisdiction to offer safe harbor to "generic pirates". The rogue jurisdiction would offer legitimate regulatory oversight in exchange for tax revenue, and the drugs would be smuggled out of the jurisdiction for sale. To some extent this is already the case in grey markets where brand name drugs which are sold for less in other countries get arbitraged/smuggled back to high-cost markets.
Here's a possible approach.
Buy n = 1024 doses of your insulin or whatever, D(0, i) for i from 0 to n - 1 = 1023, homogenize each dose, and divide each one in half into half-doses called E(0, i) and F(0, i).
Mix pairs F(0, 2*i) and F(0, 2*i + 1) into 512 new doses D(1, i) for i from 0 to 511. Homogenize these new doses and divide each one in half into half-doses called E(1, i) and F(1, i).
Mix pairs F(1, 2*i) and F(1, 2*i + 1) into 256 new doses D(2, i) for i from 0 to 255.
And so on, until in step k = lg n = 10 step you mix the half-doses F(k - 1 = 9, 0) and F(9, 1) into a single dose D(k = 10, 0). Send this D(k, 0) off to the lab to be analyzed.
If the lab is equipped to detect dangerous impurities in your insulin at one-thousandth the danger level, which is reasonable for many contaminants, and the sample comes back clean, then you know that all 1024 doses were safe, though some of them may have the wrong dose. Mix the remaining 1023 doses well so that they all have the same dose and store them safely.
If not, you need to track down the contamination (or massive dilution), so in the next iteration, you send E(9, 0) and E(9, 1) to the lab for analysis. If one of them comes back safe, you know the 511 doses that were mixed into it were okay, and you can mix them well and store them safely, then repeat the process on the contaminated subtree.
Depending on your cost function (latency, shipping and handling costs, etc.) and your priors for correlation among the samples, it might be worthwhile to recurse more deeply on failure: instead of sending E(9, i) for i from 0 to 1 to the lab, you might instead send them E(6, i) for i from 0 to 15. If one out of 30 doses was randomly contaminated, for example, about 14 out of the 16 groups will be bad on average, while if it's one out of 100, then you'll have about 7 bad groups out of 16. At some point you need to give up on the recursion, too, or you'll end up testing almost all 1024 doses when they're all bad.
This of course doesn't solve the problem of future buys, just reduces it by the factor of n.
Buy n = 1024 doses of your insulin or whatever, D(0, i) for i from 0 to n - 1 = 1023, homogenize each dose, and divide each one in half into half-doses called E(0, i) and F(0, i).
Mix pairs F(0, 2*i) and F(0, 2*i + 1) into 512 new doses D(1, i) for i from 0 to 511. Homogenize these new doses and divide each one in half into half-doses called E(1, i) and F(1, i).
Mix pairs F(1, 2*i) and F(1, 2*i + 1) into 256 new doses D(2, i) for i from 0 to 255.
And so on, until in step k = lg n = 10 step you mix the half-doses F(k - 1 = 9, 0) and F(9, 1) into a single dose D(k = 10, 0). Send this D(k, 0) off to the lab to be analyzed.
If the lab is equipped to detect dangerous impurities in your insulin at one-thousandth the danger level, which is reasonable for many contaminants, and the sample comes back clean, then you know that all 1024 doses were safe, though some of them may have the wrong dose. Mix the remaining 1023 doses well so that they all have the same dose and store them safely.
If not, you need to track down the contamination (or massive dilution), so in the next iteration, you send E(9, 0) and E(9, 1) to the lab for analysis. If one of them comes back safe, you know the 511 doses that were mixed into it were okay, and you can mix them well and store them safely, then repeat the process on the contaminated subtree.
Depending on your cost function (latency, shipping and handling costs, etc.) and your priors for correlation among the samples, it might be worthwhile to recurse more deeply on failure: instead of sending E(9, i) for i from 0 to 1 to the lab, you might instead send them E(6, i) for i from 0 to 15. If one out of 30 doses was randomly contaminated, for example, about 14 out of the 16 groups will be bad on average, while if it's one out of 100, then you'll have about 7 bad groups out of 16. At some point you need to give up on the recursion, too, or you'll end up testing almost all 1024 doses when they're all bad.
This of course doesn't solve the problem of future buys, just reduces it by the factor of n.
I think we are seeing the same thing, a system designed to remove corruption/regulatory capture/lobbying as far as possible from the process. I'm seeing a "rogue" auditor that performs the same service, while you are seeing a rogue government. If the outcome is the same, I am fine with either. Your pointed weakness regarding auditing the manufacturing process could be incorporated into either.
> I think we are seeing the same thing, a system designed to remove corruption/regulatory capture/lobbying as far as possible from the process
Not really. It's more like a system to selectively remove intellectual property rights without destroying the financial incentive to develop drugs.
Not really. It's more like a system to selectively remove intellectual property rights without destroying the financial incentive to develop drugs.
Oh. So you don't want a system that removes corruption, regulatory capture, and lobbying as far as possible? I don't want to destroy the financial incentive either, I think it's great people that bring wanted goods to market profit from it.
IP is an interesting point, although I'm not convinced that generating the IP is more than a small fraction of the cost of a drug. An aggregate I saw from 2011-2018 puts Research at only 17% of revenue, and only some proportion of that is geared towards generating IP. That is to say, with all else removed you could generate an IP only company for 17% the cost of drug sales.
IP is an interesting point, although I'm not convinced that generating the IP is more than a small fraction of the cost of a drug. An aggregate I saw from 2011-2018 puts Research at only 17% of revenue, and only some proportion of that is geared towards generating IP. That is to say, with all else removed you could generate an IP only company for 17% the cost of drug sales.
> Oh. So you don't want a system that removes corruption, regulatory capture, and lobbying as far as possible?
Well, sure. But that's not what this is actually about. The titular anarchists are not inventing new drugs, they're finding alternative ways to get drugs that have already been invented.
> That is to say, with all else removed you could generate an IP only company for 17% the cost of drug sales.
I am not convinced that accurately reflects the reality of running a pharmaceutical business, even if incentives/competition is somewhat warped in healthcare. There are a lot of penny-stock pharma companies whose only mission is to generate valuable IP. They're notorious for being volatile (since their outcome is basically binary on the results of research), but not for being great investments. If what you are asserting was actually true, those sorts of firms would generate ~5x higher returns, on average.
Well, sure. But that's not what this is actually about. The titular anarchists are not inventing new drugs, they're finding alternative ways to get drugs that have already been invented.
> That is to say, with all else removed you could generate an IP only company for 17% the cost of drug sales.
I am not convinced that accurately reflects the reality of running a pharmaceutical business, even if incentives/competition is somewhat warped in healthcare. There are a lot of penny-stock pharma companies whose only mission is to generate valuable IP. They're notorious for being volatile (since their outcome is basically binary on the results of research), but not for being great investments. If what you are asserting was actually true, those sorts of firms would generate ~5x higher returns, on average.
>Well, sure. But that's not what this is actually about. The titular anarchists are not inventing new drugs, they're finding alternative ways to get drugs that have already been invented.
... yes and they're doing so because in part regulatory capture, lobbying, and corruption have lead to unaffordable drugs. So that is, partially, what this is actually about. But sure there are other reasons for people to manufacture their own drugs outside of formal channels.
>I am not convinced that accurately reflects the reality of running a pharmaceutical business, even if incentives/competition is somewhat warped in healthcare. There are a lot of penny-stock pharma companies whose only mission is to generate valuable IP. They're notorious for being volatile (since their outcome is basically binary on the results of research), but not for being great investments. If what you are asserting was actually true, those sorts of firms would generate ~5x higher returns, on average.
That's actually my point. Generating the IP looks to be low value compared to wading through all the insane regulatory barriers, developing sales channels in-bred with medical board licensed doctors and FDA regulators that examine sales materials, lobbying for regulatory capture and all the other expensive pursuits that arguably may not add much value to the ill person consuming the drug. Another words, I'm not sure removing IP from the equation really changes the cost of drugs that much.
... yes and they're doing so because in part regulatory capture, lobbying, and corruption have lead to unaffordable drugs. So that is, partially, what this is actually about. But sure there are other reasons for people to manufacture their own drugs outside of formal channels.
>I am not convinced that accurately reflects the reality of running a pharmaceutical business, even if incentives/competition is somewhat warped in healthcare. There are a lot of penny-stock pharma companies whose only mission is to generate valuable IP. They're notorious for being volatile (since their outcome is basically binary on the results of research), but not for being great investments. If what you are asserting was actually true, those sorts of firms would generate ~5x higher returns, on average.
That's actually my point. Generating the IP looks to be low value compared to wading through all the insane regulatory barriers, developing sales channels in-bred with medical board licensed doctors and FDA regulators that examine sales materials, lobbying for regulatory capture and all the other expensive pursuits that arguably may not add much value to the ill person consuming the drug. Another words, I'm not sure removing IP from the equation really changes the cost of drugs that much.
>it's conceivable a system can be invented where private auditors audit the output of an unregulated pharmaceutical manufacturer in such a way that the QC assurances to the consumer are as good or better as in our current system, with much lower regulatory costs.
No, it's not. This is ideological libertarian nonsense. There's a reason pharma came to be regulated in the first place. All this will lead to are more injuries and death of consumers.
No, it's not. This is ideological libertarian nonsense. There's a reason pharma came to be regulated in the first place. All this will lead to are more injuries and death of consumers.
>No, it's not. This is ideological libertarian nonsense.
If I could flag your post, I would. This is purely political nonsense and a god-like attempt to disprove something through fiat.
If I could flag your post, I would. This is purely political nonsense and a god-like attempt to disprove something through fiat.
[deleted]
Heck, even the FDA can't guarantee all generics are equivalent to the branded version (some anticonvulsants come to mind). Might be a while before this ability comes to the masses.
A lot of machinery has been getting smaller. You can do GC/MS with a desktop device now.
92% of contributors to the Linux kernel are paid by companies:
https://www.suse.com/suse-defines/definition/linux-contribut...
Most major OSS projects are controlled by a few companies who pay developers to work on them. They're more like industry consortiums than DIY anarchist collectives.
Most major OSS projects are controlled by a few companies who pay developers to work on them. They're more like industry consortiums than DIY anarchist collectives.
Something can be both an industry consortium and a DIY anarchist collective, like Linux; the Linux Foundation isn't Linux. It turns out that industrial companies don't appreciate being subject to monopoly rents any more than private individuals do! The GPL is undeniably very anarchist, and it serves as a kind of constitution that keeps the companies that participate in GPL projects from controlling them. Consider, for example, Oracle and LibreOffice, MariaDB, and Jenkins, or GitHub (now Microsoft) and Git.
The solution isn't to destroy capitalism or exclude industrial companies from participation. We tried that a century ago. It went badly, because, as it turns out, capitalism is better at limiting the damage done by ambitious psychopaths than the alternative systems are; if Beria had been born in Ohio maybe he would have ended up running a soap company or a division of GE instead of mass-murdering dissidents.
Similarly, the GPL (and, to a lesser extent, non-copyleft open-source licensing) reduces the damage selfish companies can do to software projects and the people and companies that depend on them.
We need to figure out how to do the same thing to drug companies and the FDA, because they are just killing far too many people and causing far too much needless suffering today.
The solution isn't to destroy capitalism or exclude industrial companies from participation. We tried that a century ago. It went badly, because, as it turns out, capitalism is better at limiting the damage done by ambitious psychopaths than the alternative systems are; if Beria had been born in Ohio maybe he would have ended up running a soap company or a division of GE instead of mass-murdering dissidents.
Similarly, the GPL (and, to a lesser extent, non-copyleft open-source licensing) reduces the damage selfish companies can do to software projects and the people and companies that depend on them.
We need to figure out how to do the same thing to drug companies and the FDA, because they are just killing far too many people and causing far too much needless suffering today.
It's misleading to mix up anarchism and marxism-leninism. While both are anti capitalist, ML is the one where you're just replacing one hierarchy (economic power) with another (party membership). Anarchism is fundamentally against coercive hierarchy.
Anarchism is indeed fundamentally against coercive hierarchy, yes, and I apologize for not being clearer about that. That said, Emma Goldman and many other anarchists were delighted to be deported to Soviet Russia until their famous disillusionment; historically speaking, the mainstream of anarchism considered state communism more friend than enemy, until they saw how it worked out in practice. And my own experiences with nominally anti-hierarchical organizations have not given me great faith.
I think a lot of people had a lot of hope in the Soviet Union, especially when there were actual soviet councils involved. It didn't take long to devolve into a regular dictatorship. After all the state was supposed to be a vanguard for the implementation of socialism but power begets power and in the end it existed to serve itself.
I think that's the main reason that most sane leftists* are some flavour of anarchist these days.
* not including social democrats/other liberals in the "leftist" bracket.
I think that's the main reason that most sane leftists* are some flavour of anarchist these days.
* not including social democrats/other liberals in the "leftist" bracket.
How can one be both anarchist and leftist? Doesn't re-allocating resources in an unprofitable way for the owner require some sort of involuntary transaction, or would you expect owners of capital will all relinquish them peacefully? It seems like capitalism is more compatible with anarchism as capitalism can be contained within voluntary transactions.
It sounds like you would benefit from reading at least the introduction section of https://en.wikipedia.org/wiki/Anarchism.
Oxford dictionary: noun
belief in the abolition of all government and the organization of society on a voluntary, cooperative basis without recourse to force or compulsion.
That sounds compatible with mere free trade amongst men without any sort of socialism. Seems like leftism wants some involuntary reallocation of capital, but maybe I'm mistaken. If they don't I'd say they're just charitable capitalists.
That sounds compatible with mere free trade amongst men without any sort of socialism. Seems like leftism wants some involuntary reallocation of capital, but maybe I'm mistaken. If they don't I'd say they're just charitable capitalists.
Anarchism isn't just "no rules or government" as it means in common parlance; it is against coercive hierarchy in general, and capitalism is inherently coercive because it involves denial of access to means of production, and denial of access to necessary resources like food and medicine. Think of anarchism as being more akin to a modern attempt at the tribal system of humanity's prehistory, but scaled up: resources being pooled and shared instead of traded transactionally. There are other interpretations of anarchist productive organisation but that's a common one.
How are you going to take my means of production (in my case, my electronics manufacturing and design lab) and use it for something else (un-deny the access)?
Or say I have a full fledged industrial scale wave soldering, mass PnP, full inventory of millions of dollars worth of components. I need it to feed my family, I'm not going to just hand it to you after I gained it through consensual trade fair and square. Doesn't that require coercion? I'm not just going to give up my goods I worked hard for, what's going to happen when the comrades see the loaded barrel of a rifle protecting that which feeds my family? I think a lot of people needing to feed there families are going to have a lot of rifles, and they're not going to be very happy about someone coming along to "open up access" to means of production of their business.
When you take my means of production, you deny ME access to what I gained without coercion, by using coercion.
This all just sounds like a violent way of less efficiently allocating capital, under the guise of non-coercion. Access to property should require consent, otherwise you have coercion. Seems to me free market trading of private property fits a lot more neatly with the oxford definition of anarchism.
Or say I have a full fledged industrial scale wave soldering, mass PnP, full inventory of millions of dollars worth of components. I need it to feed my family, I'm not going to just hand it to you after I gained it through consensual trade fair and square. Doesn't that require coercion? I'm not just going to give up my goods I worked hard for, what's going to happen when the comrades see the loaded barrel of a rifle protecting that which feeds my family? I think a lot of people needing to feed there families are going to have a lot of rifles, and they're not going to be very happy about someone coming along to "open up access" to means of production of their business.
When you take my means of production, you deny ME access to what I gained without coercion, by using coercion.
This all just sounds like a violent way of less efficiently allocating capital, under the guise of non-coercion. Access to property should require consent, otherwise you have coercion. Seems to me free market trading of private property fits a lot more neatly with the oxford definition of anarchism.
You seem to be confusing anarchism with libertarianism. Libertarianism is basically capitalism on steroids; it's an individualistic, "rules-are-for-little-people" ideology. Anarchism is any of several different kinds of non-hierarchical socialism.
For clarity, by "socialism" I don't mean Robin Hood socialism, taking from the rich to give to the poor; that's coercive. I mean that socialists aim for a more-equal society. So I'm saying that anarchists are people that aim for a more equal society, and hope to achieve that using processes and structures that minimise hierarchy.
For clarity, by "socialism" I don't mean Robin Hood socialism, taking from the rich to give to the poor; that's coercive. I mean that socialists aim for a more-equal society. So I'm saying that anarchists are people that aim for a more equal society, and hope to achieve that using processes and structures that minimise hierarchy.
Capitalism isn't incompatible with anarchism unless you're speaking with leftist.
Anarchism is leftist.
I consider myself anarchist in the sense I do not believe in the legitimacy of government. I do not have any leftist view whatsoever, but I think people should retain ownership of their property except through consensual trade. Does that mean I'm not an anarchist, or does that mean I'm a leftist?
I suppose it depends on what definitions you're using of words like "government", "leftist view", "their property", and "anarchist"; clearly at least one of them differs from the mainstream definitions. I suspect it's "anarchist", since anarchism (as normally understood) opposes coercive hierarchy more broadly than just the usual definition of "government", including things sometimes described as "property", but I can't know for sure; you might be using a nonstandard definition of "government" instead, for example.
As I said before, though, you might benefit from reading at the introductory section of https://en.wikipedia.org/wiki/Anarchism.
As I said before, though, you might benefit from reading at the introductory section of https://en.wikipedia.org/wiki/Anarchism.
I've looked it over. I understand leftists have a rich history of invoking anti-state ideology. I'm using the oxford definition of anarchism.
I'm not saying leftists can't exist in anarchism as some sort of pact or contract amongst leftist, in the sense of without coercive hierarchy. But I don't see how anarchism is inherently leftist. If leftism means socialism or some form of redistributing property involuntarily, that sounds coercive.
Voluntary exchange of property and capital is the opposite of coercion. It seems capitalism fits in neatly with anarchism.
I'm not saying leftists can't exist in anarchism as some sort of pact or contract amongst leftist, in the sense of without coercive hierarchy. But I don't see how anarchism is inherently leftist. If leftism means socialism or some form of redistributing property involuntarily, that sounds coercive.
Voluntary exchange of property and capital is the opposite of coercion. It seems capitalism fits in neatly with anarchism.
> I'm using the oxford definition of anarchism.
Which Oxford definition? You've cited "The Oxford Dictionary" up-thread. There's a bunch of online lexicographical resources that are unrelated to the OED, but trade on its name and reputation.
At any rate, a brief definition from a concise lexicon is no substitute for doing some proper reading on the subject. And even reading will leave you pretty confused about how it can possibly work; participation in an anarchist collective might blow your mind.
Which Oxford definition? You've cited "The Oxford Dictionary" up-thread. There's a bunch of online lexicographical resources that are unrelated to the OED, but trade on its name and reputation.
At any rate, a brief definition from a concise lexicon is no substitute for doing some proper reading on the subject. And even reading will leave you pretty confused about how it can possibly work; participation in an anarchist collective might blow your mind.
https://languages.oup.com/google-dictionary-en/
Anarchism isn't some cursory subject for me. Someone up thread mentioned Rojava as an example of something closest to an anarchist collective. I went there and lived there. What I found was voluntary trade which we commonly call capitalism. I find this to be compatible with anarchism when trades are made voluntarily and not say, by strong arm of government forcing how you trade with people or the strong arm of some "anarchist" "opening up access" to your capital.
Anarchism isn't some cursory subject for me. Someone up thread mentioned Rojava as an example of something closest to an anarchist collective. I went there and lived there. What I found was voluntary trade which we commonly call capitalism. I find this to be compatible with anarchism when trades are made voluntarily and not say, by strong arm of government forcing how you trade with people or the strong arm of some "anarchist" "opening up access" to your capital.
I would consider "opening up access" to someone else's capital to be a kind of theft, in general, and not consistent with anarchism. When the capital in question is means-of-production that the workers have contributed to building, things are a bit less clear-cut.
Allowing workers to join the board, perhaps as a response to an all-out strike, might be a step towards worker's collectives.
It's much easier to articulate the objectives than the path.
Allowing workers to join the board, perhaps as a response to an all-out strike, might be a step towards worker's collectives.
It's much easier to articulate the objectives than the path.
I just checked out Rojava on wikipedia; it's a new one on me. Turns out it's what I have thought to be the Kurdish Autonomous Region.
I have heard that KAR operates on roughly-anarchist lines, and works well; I'm very interested in large-scale, working, contemporary anarchist and collective societies. The only other one I can think of is Catalunya, which is sometimes described as anarchist. It appears to me to be mostly capitalism with a strong public sector, along with some major collectivised industries. But I'm not familiar with how decisions are made.
I'm very interested to hear that you've spent time in Rojava.
[Edit] Clarified, I hope.
I have heard that KAR operates on roughly-anarchist lines, and works well; I'm very interested in large-scale, working, contemporary anarchist and collective societies. The only other one I can think of is Catalunya, which is sometimes described as anarchist. It appears to me to be mostly capitalism with a strong public sector, along with some major collectivised industries. But I'm not familiar with how decisions are made.
I'm very interested to hear that you've spent time in Rojava.
[Edit] Clarified, I hope.
It means you're an extreme libertarian, but no anarchist.
That's just leftist gate-keeping of anarchism. A completely voluntary system of free trade isn't incompatible with a system without coercion. Note I consider something coercion when it is performed by violence by the aggressor, a victim can fight back and I won't classify that as coercion.
It's only "leftist gatekeeeping" if you're wedded to the idiosyncratic notion that anarchism is not a form of socialism.
From the language you use, I suspect you are a USAian; the term "leftist" seems to be used mainly as a term USAians use to express their contempt for socialism. In most of the world, "socialism" is not a bad word. But the term "leftist" is often used by authoritarians to describe the "terrorists" they're using the army to suppress.
From the language you use, I suspect you are a USAian; the term "leftist" seems to be used mainly as a term USAians use to express their contempt for socialism. In most of the world, "socialism" is not a bad word. But the term "leftist" is often used by authoritarians to describe the "terrorists" they're using the army to suppress.
I could be wrong but I infered on your other response you're ok with people keeping the fruits of their labor. If you're ok with them trading those fruits I'd call you a capitalist, not a socialist. Some of those fruits and some of those trades may be means of production, like a drill press or factory floor or whatever. Unless of course you're strong arming someone with violence to hand over some of those fruits.
I'm ok with socialism when it's done consensually. If a bunch of people want to go live on a commune, more power to them. It's when you come for the equipment and capital I use to manufacture things and feed my family, is when you're gonna start needing the commune comrades to enact violence if you want to steal that from me. And to do that seems.... coercive and non-anarchistic.
I'm ok with socialism when it's done consensually. If a bunch of people want to go live on a commune, more power to them. It's when you come for the equipment and capital I use to manufacture things and feed my family, is when you're gonna start needing the commune comrades to enact violence if you want to steal that from me. And to do that seems.... coercive and non-anarchistic.
I'm OK with people keeping the fruits of their labour. Up to a point. When you get people using money to get more money, exponentially, until they've got so much they can't think of ways to spend it and start buying NFTs and building space rockets, it's gone way too far. So I'm good with keeping "fruits of labour" if that's what you need to live, subject to the constraints of tax policy.
My own political views are neither here nor there. I live in the UK, but I don't support Labour; I don't think Labour is socialist, and I do think they're authoritarian and militarist. I don't know how you can scale up anarchism from a collective to a nation; I do know when things are going in the wrong direction.
> I'm ok with socialism when it's done consensually.
You mean, when you can opt out, apparently.
My own political views are neither here nor there. I live in the UK, but I don't support Labour; I don't think Labour is socialist, and I do think they're authoritarian and militarist. I don't know how you can scale up anarchism from a collective to a nation; I do know when things are going in the wrong direction.
> I'm ok with socialism when it's done consensually.
You mean, when you can opt out, apparently.
>What if everyone had an analysis machine that could analyze the medicines
Because, as a post below notes, this is a pure fantasy. At this point you're proposing actual magic.
>Linux versus, say, Solaris and Microsoft Windows
Your choice of operating system isn't going to severely harm or kill you. "Move fast and break things" is a problem when the "things" are people.
>medical consequences have to get pretty costly before they're more costly than selling your home and emptying your retirement account and your kids' college funds.
Welcome to the reality of healthcare in the US for the uninsured (and often times for the poorly-insured).
Because, as a post below notes, this is a pure fantasy. At this point you're proposing actual magic.
>Linux versus, say, Solaris and Microsoft Windows
Your choice of operating system isn't going to severely harm or kill you. "Move fast and break things" is a problem when the "things" are people.
>medical consequences have to get pretty costly before they're more costly than selling your home and emptying your retirement account and your kids' college funds.
Welcome to the reality of healthcare in the US for the uninsured (and often times for the poorly-insured).
Meh it's the classic black market vs white market debate, where here the white market is a huge oligopoly with insane markups to pay off lobbyists / regulator / advertisers / the rich people who own the pharma companies. Sometimes the black market is even more expensive but in DIY it often isn't.
If it were me I'd just make it all in one go, hopefully enough to be set for life, huge pile of it whatever drug I need to stay alive. Create a homogeneous mixture, GC/MS the mixture for purity and then package it for long term storage.
If it were me I'd just make it all in one go, hopefully enough to be set for life, huge pile of it whatever drug I need to stay alive. Create a homogeneous mixture, GC/MS the mixture for purity and then package it for long term storage.
some university will buy it first! actually this sounds like good, but this so difficult.
if someone glad to try some secret drug, maybe they can killed by error one...
if someone glad to try some secret drug, maybe they can killed by error one...
> People mostly aren't dying because they can't afford life-saving medicine.
I don’t where you live. But in California there are clearly destitute people on the street in need of simple medical interventions like antibiotics.
For whatever reason* they aren’t able to get medical help — and I’m not just meaning people in mental crisis and drug addiction. There are seemingly “regular” people suffering from what should be 19th century style deaths.
* I’ve noticed that EMTs are very cynical about helping poor looking people. I’m sure the classism extends to getting care, even when hospitals are legally required to provide immediate help without taking finances in to account.
I don’t where you live. But in California there are clearly destitute people on the street in need of simple medical interventions like antibiotics.
For whatever reason* they aren’t able to get medical help — and I’m not just meaning people in mental crisis and drug addiction. There are seemingly “regular” people suffering from what should be 19th century style deaths.
* I’ve noticed that EMTs are very cynical about helping poor looking people. I’m sure the classism extends to getting care, even when hospitals are legally required to provide immediate help without taking finances in to account.
Affordability is not the only reason people are being denied medicine. Many people have wanted, e.g. ivermectin, monoclonal antibodies, etc; and even gone to court to fight to get them, not because of the cost but because doctors, pharmacies and/or government bodies refuse to provide.
The -mabs are often denied because they really are expensive to make. Ivermectin is super cheap and quite safe in the usual doses; in the case of covid, denying it to people isn't directly causing any harm, but also very little good, if any.
>The -mabs are often denied because they really are expensive to make.
Source? According to the HHS via Washington Post[1], many doses of monoclonal antibodies have already been made, but only 20% of those distributed have been used, with 80% sitting on a shelf. The article suggests a few reasons for the lack of use, but it does not mention cost to make them.
[1]https://archive.fo/IHK4J
Source? According to the HHS via Washington Post[1], many doses of monoclonal antibodies have already been made, but only 20% of those distributed have been used, with 80% sitting on a shelf. The article suggests a few reasons for the lack of use, but it does not mention cost to make them.
[1]https://archive.fo/IHK4J
It says 0.378 million doses have been distributed to healthcare facilities in the US. There have been 58 million confirmed cases in the US, 0.62 million new cases yesterday and 0.56 million new cases the day before. If they were to give those unallocated doses to every new covid case, they would be gone in 12 hours.
So they are not abundant; they are scarce. Not enough are being made.
It is true that I don't know how much Regeneron and Lilly are spending on making them, or how much they are getting paid, but monoclonal antibodies are usually very expensive, and I infer from the production levels that the expense is high enough that they don't have ten million doses sitting around just waiting to ship out.
So they are not abundant; they are scarce. Not enough are being made.
It is true that I don't know how much Regeneron and Lilly are spending on making them, or how much they are getting paid, but monoclonal antibodies are usually very expensive, and I infer from the production levels that the expense is high enough that they don't have ten million doses sitting around just waiting to ship out.
I can get the medicines I need to "save" me. I can't get the medicines that would help me to die. I wonder what this group's moral posture is on using their equipment to manufacture Nembutal (or other barbiturates).
I would like to have 15g of Nembutal in a safe place, so that I can kill myself painlessly and without leaving a mess, should the circumstances require that. I know that no medical professional would help me do that, because they would immediately be disqualified. Instead they would have to strive officiously to prolong my life.
Nembutal is illegal to possess, at least it is here. That's not like the drugs this group are helping people to make, which are all legal to possess provided you have a prescription, or so the article says. There's no "therapeutic" use for Nembutal that can't be met by a safer drug.
As a result Nembutal is really difficult to source (also because it's part of the traditional cocktail used in US death-by-poisoning executions).
I would like to have 15g of Nembutal in a safe place, so that I can kill myself painlessly and without leaving a mess, should the circumstances require that. I know that no medical professional would help me do that, because they would immediately be disqualified. Instead they would have to strive officiously to prolong my life.
Nembutal is illegal to possess, at least it is here. That's not like the drugs this group are helping people to make, which are all legal to possess provided you have a prescription, or so the article says. There's no "therapeutic" use for Nembutal that can't be met by a safer drug.
As a result Nembutal is really difficult to source (also because it's part of the traditional cocktail used in US death-by-poisoning executions).
>I would like to have 15g of Nembutal in a safe place, so that I can kill myself painlessly and without leaving a mess
Wouldn't this inevitably leave a mess when your dead body bloats and eventually spills open the quickly decaying contents?
Wouldn't this inevitably leave a mess when your dead body bloats and eventually spills open the quickly decaying contents?
[deleted]
This is pretty interesting, but skimming the article I didn't see any mention of lab testing the purity and quantity of drugs produced. There's a lot of fiery talk but how do we know that the results are usable?
This is a very important step in the production of medications. We need to know that nothing went wrong with the synthesis and we aren't ingesting toxic and potentially fatal byproducts. Dosage can also be wrong if measuring an impure compound.
Imagine injecting too much epi! Not good!
Honestly my concern is too little. Say you make a measurement expecting 90% purity but its actually 60%. You're getting way less epi and may continue struggling to breathe after taking the shot. Scary shit.
Due to the pandemic I’ve often thought about what the ideal model for vaccines and other drugs would be. I understand that there’s enormous costs for pharma companies to bring a new drug to the market, and I guess a lot of new drug prospects end up not going anywhere, but it’s hard to swallow that there’s drugs out there that are cheap to manufacture and are life saving (or life changing) for people that need them yet some/many of them can’t afford them.
What’s the best way to fix this? Direct government funding? Indirect one via subsidising the drugs for those who need it? Im
What’s the best way to fix this? Direct government funding? Indirect one via subsidising the drugs for those who need it? Im
For one thing we can cut down on red tape. The covid vaccines have proven that the typical FDA approval process is way too long. Trials are usually the most expensive part of drug development, so this would cut down on costs to consumers by a lot.
This was 2018 and the link to fourthievesvinegar.org is dead, where are they now?
They're active on Twitter: https://twitter.com/4ThievesVinegar
But they claim their site has been under construction for about a year now.
I think it's important to note that this group is more about political activism and getting headlines than they are about actually producing and distributing the medication.
But they claim their site has been under construction for about a year now.
I think it's important to note that this group is more about political activism and getting headlines than they are about actually producing and distributing the medication.
It's all fun and games until somebody reacts badly and dies.
My first thought was how dangerous this is. Then after thinking some more, I was left questioning how a developed country can mess up so badly that some people feel this is their only option.
Also, the article mentions an MIT professor's safety concerns, but, upon reflection, given the conditions some of these drugs are meant to treat, the error rate would have to be very high to make it worse than no treatment.
> I was left questioning how a developed country can mess up so badly that some people feel this is their only option.
Regulatory capture.
Regulatory capture.
That and market failure.
The market tends to fail when it's strangled by regulations (which pleases the large incumbents, whose necks are much thicker than their competitors). For any apparent market failure, try translating your complaint into a business plan, and see what obstacles you hit. "These drugs are way too expensive. Why can't I make a profit by making the drug and selling it for a lower price?" Answer: the patent system forbids it.
And for medical conditions that don't yet have drugs developed: "Why can't I make a profit by investing some reasonable amount of money to develop a drug?" https://en.wikipedia.org/wiki/Cost_of_drug_development puts the average cost in the billions of dollars. How much of that is due to intrinsic difficulty, and how much is artificially imposed?
And for medical conditions that don't yet have drugs developed: "Why can't I make a profit by investing some reasonable amount of money to develop a drug?" https://en.wikipedia.org/wiki/Cost_of_drug_development puts the average cost in the billions of dollars. How much of that is due to intrinsic difficulty, and how much is artificially imposed?
I'm not sure if life saving medicine should or even can be understood through economic equilibrium. This is ultimately a question of ethics, politics and sheer survival. This isn't a market in the first place and it doesn't help that we pretend it is.
Everything is a market. Someone has to produce a finite supply for some cost. There is some demand for the medicine. Suppliers can be incentivized to produce by demand through price.
Look up the percentage of all drugs that were invented in the United States. Socialized medicine is subsidized by capitalist innovation overseas. There are so many problems with the US system, but they have more to do with regulatory capture (including difficulty of FDA approval + difficulty of becoming a doctor) and price transparency than anything else.
Look up the percentage of all drugs that were invented in the United States. Socialized medicine is subsidized by capitalist innovation overseas. There are so many problems with the US system, but they have more to do with regulatory capture (including difficulty of FDA approval + difficulty of becoming a doctor) and price transparency than anything else.
Sit tight and assess! This is like reading a propaganda pamphlet with the inevitable very long term "it may work, we'll have to wait and see in a decade or two, but until then at least our profits are not affected"-solutions.
Did you forget to read the last part, describing the major things that need to change?
I did not.
Then you clearly misunderstood and your response adds no value. Nobody said sit tight. I said change some major things with powerful gatekeepers. Don't let your ideology get in the way of entertaining new ideas.
I did not misunderstand you. The suggested changes are bullshit.
From your comment history, it appears you have a problem with making HN-quality comments [0]. Reddit's always an option if you don't want to change.
Otherwise, please work on entertaining new ideas and contributing with your own ideas/suggestions/explanations rather than being "that guy" who shits on people with low value comments lacking any reason or explanation (typically because they are wrong but don't want to admit their position for fear of ridicule by people like themselves).
[0] https://news.ycombinator.com/newsguidelines.html
Otherwise, please work on entertaining new ideas and contributing with your own ideas/suggestions/explanations rather than being "that guy" who shits on people with low value comments lacking any reason or explanation (typically because they are wrong but don't want to admit their position for fear of ridicule by people like themselves).
[0] https://news.ycombinator.com/newsguidelines.html
If you send your compounds off for proper testing it shouldn't be that dangerous, but that will increase the cost a few 100% most likely
Testing usually doesn't come cheap, but you also might be able to drop by a well equipped Chem department at a university for testing as well
Testing usually doesn't come cheap, but you also might be able to drop by a well equipped Chem department at a university for testing as well
> If you send your compounds off for proper testing it shouldn't be that dangerous, but that will increase the cost a few 100% most likely
> Testing usually doesn't come cheap, but you also might be able to drop by a well equipped Chem department at a university for testing as well
I don't think it's that easy. Even if you successfully synthesize the right chemical, you also have to get dosage and delivery right (consistently!).
From the OP:
> In response, Four Thieves published the instructions for a DIY epipen online that can be made for $30 in off-the-shelf parts and reloaded for $3.
If I had to depend on an epipen to save my life, I don't think I'd want a DIY version that may not work when I need it (e.g. mechanism fails, storage stability issues, dosage issues, etc.). Sure I guess it's better than nothing, but it's also proof this clearly isn't the solution to the $600 epipen problem.
> Shkreli drove the price of the lifesaving HIV medicine Daraprim sells up to $750 per pill. So Four Thieves developed an open source portable chemistry lab that allows anyone to manufacture their own Daraprim for just 25 cents apiece.
The article calls Daraprim and "HIV medicine" throughout, but isn't that misleading? I thought it was an anti-parasitic (that may be used by HIV patients to treat secondary infections).
> Testing usually doesn't come cheap, but you also might be able to drop by a well equipped Chem department at a university for testing as well
I don't think it's that easy. Even if you successfully synthesize the right chemical, you also have to get dosage and delivery right (consistently!).
From the OP:
> In response, Four Thieves published the instructions for a DIY epipen online that can be made for $30 in off-the-shelf parts and reloaded for $3.
If I had to depend on an epipen to save my life, I don't think I'd want a DIY version that may not work when I need it (e.g. mechanism fails, storage stability issues, dosage issues, etc.). Sure I guess it's better than nothing, but it's also proof this clearly isn't the solution to the $600 epipen problem.
> Shkreli drove the price of the lifesaving HIV medicine Daraprim sells up to $750 per pill. So Four Thieves developed an open source portable chemistry lab that allows anyone to manufacture their own Daraprim for just 25 cents apiece.
The article calls Daraprim and "HIV medicine" throughout, but isn't that misleading? I thought it was an anti-parasitic (that may be used by HIV patients to treat secondary infections).
> If I had to depend on an epipen to save my life, I don't think I'd want a DIY version that may not work when I need it. Sure I guess it's better than nothing, but it's also proof this clearly isn't the solution to the $600 epipen problem.
DIY versions are normally more expensive than mass-produced equivalents. So either this DIY version has atrocious quality, or $600 is far too expensive. (Judging by the prices in normal countries, $600 is far too expensive!)
DIY versions are normally more expensive than mass-produced equivalents. So either this DIY version has atrocious quality, or $600 is far too expensive. (Judging by the prices in normal countries, $600 is far too expensive!)
> DIY versions are normally more expensive than mass-produced equivalents. So either this DIY version has atrocious quality, or $600 is far too expensive. (Judging by the prices in normal countries, $600 is far too expensive!)
Yeah, the answer is $600 is far too expensive.
IMHO the answer is some kind of regulation (e.g. limiting the profit margin on generics or even drugs more generally), or some kind of boutique government-owned generic maker tasked with being a manufacturer of last resort and selling generics at its cost (which should be higher than a non-price-gouging private company, so it works to put a price-ceiling on those companies and also acts as insurance against unavailability).
Yeah, the answer is $600 is far too expensive.
IMHO the answer is some kind of regulation (e.g. limiting the profit margin on generics or even drugs more generally), or some kind of boutique government-owned generic maker tasked with being a manufacturer of last resort and selling generics at its cost (which should be higher than a non-price-gouging private company, so it works to put a price-ceiling on those companies and also acts as insurance against unavailability).
> IMHO the answer is some kind of regulation
IMHO, the solution is actually less regulation.
If any company could enter that market with being sued into the ground, you'd get top notch a quality product for a fraction of the price before you could finish spelling epinephrine.
IMHO, the solution is actually less regulation.
If any company could enter that market with being sued into the ground, you'd get top notch a quality product for a fraction of the price before you could finish spelling epinephrine.
> IMHO, the solution is actually less regulation.
> If any company could enter that market with being sued into the ground, you'd get top notch a quality product for a fraction of the price before you could finish spelling epinephrine.
I doubt it. IIRC, EpiPens are off-patent, and the only thing holding back competition is the need to demonstrate the competing product is safe, reliable, and equivalent. I even believe a competitor product was withdrawn from the market because it was delivering an unreliable dosage.
So if you remove the regulations, you'll probably get a flood of corner-cutting crap that's dangerous. That's likely especially true for an emergency use item like an EpiPen, which literally sits on a shelf unused unless there's an emergency (leaving a big opportunity to sell defective items undetected by consumers).
> If any company could enter that market with being sued into the ground, you'd get top notch a quality product for a fraction of the price before you could finish spelling epinephrine.
I doubt it. IIRC, EpiPens are off-patent, and the only thing holding back competition is the need to demonstrate the competing product is safe, reliable, and equivalent. I even believe a competitor product was withdrawn from the market because it was delivering an unreliable dosage.
So if you remove the regulations, you'll probably get a flood of corner-cutting crap that's dangerous. That's likely especially true for an emergency use item like an EpiPen, which literally sits on a shelf unused unless there's an emergency (leaving a big opportunity to sell defective items undetected by consumers).
The computer market is not particularly regulated, yet we still have international big tech monopolies stifling competition. I think the US simultaneously needs:
• less regulation, to reduce barriers-to-entry
• more regulation, to allow competition
Normally, I'd be concerned about reduced regulations having safety implications, but the existing situation is already unsafe.
• less regulation, to reduce barriers-to-entry
• more regulation, to allow competition
Normally, I'd be concerned about reduced regulations having safety implications, but the existing situation is already unsafe.
Patents are a big part of how the stifling is done. Getting rid of them, or at least cutting their term by a factor of 3-4, would help a great deal.
While I agree that patents are net harmful, especially in software, if you cut their term by a factor of 4 to 5 years, many of them would expire before being granted, which would be a hard policy to defend.
Heh, interesting. Perhaps that problem would self-correct after a while; if the payoff for a patent was lower, fewer would apply and there would be less of a backlog... Hmm, looking into it, https://www.uspto.gov/dashboard/patents/pendency.html measures a bunch of different things, but it seems "traditional total pendency" is the main metric, and it seems to be about 2 years on that at the moment. Of course, if there's high variance, then that could mean that a bunch do take 5 years.
That said, if a patent is pending and no one knows when it'll be granted, is that not enough? Would competitors really introduce their own patent-violating version, knowing they may have to suddenly cut production if the patent goes through? Do they do that today?
At any rate, those delays seem absurd; presumably they're due to having a backlog, due to the USPTO not employing enough people, due presumably to them not having enough of a budget. Not that I'm in favor of giving money to patent-granters, though. I wonder if a fee paid by the patent-holders—say, a small percentage of the revenue from selling patented products—would be a reasonable way to fund it.
That said, if a patent is pending and no one knows when it'll be granted, is that not enough? Would competitors really introduce their own patent-violating version, knowing they may have to suddenly cut production if the patent goes through? Do they do that today?
At any rate, those delays seem absurd; presumably they're due to having a backlog, due to the USPTO not employing enough people, due presumably to them not having enough of a budget. Not that I'm in favor of giving money to patent-granters, though. I wonder if a fee paid by the patent-holders—say, a small percentage of the revenue from selling patented products—would be a reasonable way to fund it.
Competitors might have a bigger incentive to try to delay the granting of the patent with red tape.
I don't know how common it is today to introduce a product while planning to cancel it if a competitor's pending patent gets granted.
The funding of the PTO has been a contentious political issue for decades.
I don't know how common it is today to introduce a product while planning to cancel it if a competitor's pending patent gets granted.
The funding of the PTO has been a contentious political issue for decades.
Not with epinephrine, because it's out-of-patent. For clarity, I very much dislike the patent system.
Epinephrine itself, sure. Epipens, though? Looking at https://en.wikipedia.org/wiki/Epinephrine_autoinjector , I see "In 2009, Teva Pharmaceuticals filed an ANDA to market a generic EpiPen in collaboration with Antares Pharma Inc, a maker of injection systems; Pfizer and King sued them for infringing US Patent 7,449,012 that was due to expire in 2025", and "In 2010, Pfizer and King sued Novartis' Sandoz generic unit for patent infringement after Sandoz submitted an ANDA to sell a generic EpiPen."
You need a delivery mechanism that can be used quickly and reasonably safely, ideally by someone in the early stages of anaphylaxis. Taking out a vial and a syringe, and carefully extracting the epinephrine from the vial with the syringe, are not things you'd want to be doing under those circumstances. Hence the invention of better approaches.
But epipens were originally "brought to market in 1983". How are there still active patents for it? "Kaplan continued to improve his designs over the years, filing for example US Patent 6,767,336 in 2003." I wonder if the new patents cover the 1983 devices. If so, that seems like an obvious abuse of the system: keep filing a new patent for different aspects of or variations on the device, and you can multiply the duration of your monopoly grant.
You need a delivery mechanism that can be used quickly and reasonably safely, ideally by someone in the early stages of anaphylaxis. Taking out a vial and a syringe, and carefully extracting the epinephrine from the vial with the syringe, are not things you'd want to be doing under those circumstances. Hence the invention of better approaches.
But epipens were originally "brought to market in 1983". How are there still active patents for it? "Kaplan continued to improve his designs over the years, filing for example US Patent 6,767,336 in 2003." I wonder if the new patents cover the 1983 devices. If so, that seems like an obvious abuse of the system: keep filing a new patent for different aspects of or variations on the device, and you can multiply the duration of your monopoly grant.
It makes more sense when you realize that much of US population is ok with vulture capitalism: extract as much rent as possible from everything, no matter the consequence to society or harms done, especially if focused on poor people.
See also payday loans, overage bank fees, credit card APRs, etc.
See also payday loans, overage bank fees, credit card APRs, etc.
this will be useful in 20 years when society has collapsed, but you want to survive
> After a few minutes of gloating about pharma bro Martin Shkreli “rotting at Fort Dix” for raising the price of Daraprim, a lifesaving HIV medicine, from $13 to $750, Laufer grew serious. “It’s been two years, but despite everything that’s happened, the price of Daraprim hasn’t changed,” he said.
Shkreli went to jail for securities fraud- not raising the price of a drug. I think Shkreli was a convenient scapegoat for the pharmaceutical industry though. All the time and energy people spent angry at Shkreli was time spent not directing their anger at the industry that allowed it.
Shkreli went to jail for securities fraud- not raising the price of a drug. I think Shkreli was a convenient scapegoat for the pharmaceutical industry though. All the time and energy people spent angry at Shkreli was time spent not directing their anger at the industry that allowed it.
while all that drama on the surface, the industry had coopted government's War on Drugs and pushed opiates (great thing when used as needed) into the opioid epidemics, and now they coopted government's War on Covid and has been pushing billions of doses of the vaccines (great thing when it works) which clearly fail to control the spread (and thus these vaccines have only limited use, i.e. only for the people who really need it (like high risk groups, etc.) - the situation pretty similar to opioids. And if one looks at those 3rd, 4th, ... boosters - sales tactic wise it looks eerily similar to the jacking up the "12hr" opioid dose approach as it simultaneously increases sales and creates addiction). I wonder if several years down the road we'll see vaccine trials/settlements similar to the opioids ones.
> these vaccines have only limited use
It's clear that the vaccines don't confer total immunity. They do change the course of the infection if you contract it, though. As you'd expect: they induce your immune system to create antibodies.
Spend even a few minutes browsing stories from ICU nurses and you'll conclude that pretty much all their admissions are unvaccinated.
Vaccinated => get sick Unvaccinated => get very sick, maybe die
That seems like a great utility to me.
Sure, that's anecdata, but data doesn't convince people who call others "sheep"
It's clear that the vaccines don't confer total immunity. They do change the course of the infection if you contract it, though. As you'd expect: they induce your immune system to create antibodies.
Spend even a few minutes browsing stories from ICU nurses and you'll conclude that pretty much all their admissions are unvaccinated.
Vaccinated => get sick Unvaccinated => get very sick, maybe die
That seems like a great utility to me.
Sure, that's anecdata, but data doesn't convince people who call others "sheep"
that has no meaningful bearing on the situation of many people who has very low risk of serious decease to start with. Yet the industry got its way, and the vaccines are forced down the everybody's throat.
Seems like they're pretty different cases, given how life-destroying opioid addiction is.
Pushing vaccines is mostly just profiting by adding another layer of bureaucracy and annoyance into daily life.
I'm not really more angry at pfizer than I am Booz Allen for wasting however many billions of my tax dollars.
Pushing vaccines is mostly just profiting by adding another layer of bureaucracy and annoyance into daily life.
I'm not really more angry at pfizer than I am Booz Allen for wasting however many billions of my tax dollars.
>Seems like they're pretty different cases, given how life-destroying opioid addiction is.
Pfizer/Booz Allen waste of billions of tax dollars do come with resulting indirect damage to people health and lives who could have been helped otherwise. And for direct damage - I think jury is still out on that one. For example, in UK according to the link they already count 0.3M of heart issues which they officially pinned on pandemic stress
https://www.standard.co.uk/news/health/post-pandemic-stress-...
with more expected to come:
"Mark Rayner, a former senior NHS psychological therapist and founder of EASE Wellbeing CIC, said that as many as three million people in Britain are already suffering from PPSD, thanks to stress and anxiety caused by the effects of Covid-19.
He fears this could result in a dramatic rise in physical health issues, such as coronary heart failure, if cases are not detected or treated early."
Pinning on pandemic stress means they couldn't pin it on covid - either it is non-infected people or timing isn't correlated enough. Now, simple politically correct choice - stress or mRNA vaccines known for causing heart issues?
Pfizer/Booz Allen waste of billions of tax dollars do come with resulting indirect damage to people health and lives who could have been helped otherwise. And for direct damage - I think jury is still out on that one. For example, in UK according to the link they already count 0.3M of heart issues which they officially pinned on pandemic stress
https://www.standard.co.uk/news/health/post-pandemic-stress-...
with more expected to come:
"Mark Rayner, a former senior NHS psychological therapist and founder of EASE Wellbeing CIC, said that as many as three million people in Britain are already suffering from PPSD, thanks to stress and anxiety caused by the effects of Covid-19.
He fears this could result in a dramatic rise in physical health issues, such as coronary heart failure, if cases are not detected or treated early."
Pinning on pandemic stress means they couldn't pin it on covid - either it is non-infected people or timing isn't correlated enough. Now, simple politically correct choice - stress or mRNA vaccines known for causing heart issues?
> Now, simple politically correct choice - stress or mRNA vaccines known for causing heart issues?
Huh? You assume the vaccines cause heart issues, and use as evidence for concluding that vaccines cause heart issues...? Did I misunderstand?
I don't really have an opinion here since I haven't looked at any of the data you're referencing.
Moreover, this is straying from my initial point, which was that opioid addiction is life-destroying on an scale far beyond what we have yet seen from vaccines, and it doesn't even require any careful study to see that since the effect size is so huge, with explicit societal harm in the form of drug trafficking, crime, and overdose deaths.
Huh? You assume the vaccines cause heart issues, and use as evidence for concluding that vaccines cause heart issues...? Did I misunderstand?
I don't really have an opinion here since I haven't looked at any of the data you're referencing.
Moreover, this is straying from my initial point, which was that opioid addiction is life-destroying on an scale far beyond what we have yet seen from vaccines, and it doesn't even require any careful study to see that since the effect size is so huge, with explicit societal harm in the form of drug trafficking, crime, and overdose deaths.
Pro-opiate and anti-vax? Niiiice!
I'd like to be able to discuss ideas on their merits instead of being confronted with factional applause lights like "anti-vax".
Arguments like "clearly fail to control the spread" are low effort Gish Gallops that need to be treated as such.
Publicly slugging it out in the weeds grants an optical stalemate to an argument that deserves to lose. Do this a million times in a row and you can launch an entire contrarian movement off vapors -- which is exactly what we have seen.
Publicly slugging it out in the weeds grants an optical stalemate to an argument that deserves to lose. Do this a million times in a row and you can launch an entire contrarian movement off vapors -- which is exactly what we have seen.
I don't see any arguments beside cheap meta and labels from your side (which seems to be pretty characteristic of the people pushing the current vaccine campaign).
>Arguments like "clearly fail to control the spread" are low effort Gish Gallops that need to be treated as such.
The failure to control the spread has been obvious for at least half-a-year for anybody doing simple arithmetic on public numbers (and like others i have commented on that as far back then). Now beside being obvious, it is also confirmed by a proper scientific publication
https://www.nature.com/articles/d41586-021-02689-y
" A person who was fully vaccinated and then had a ‘breakthrough’ Delta infection was almost twice as likely to pass on the virus as someone who was infected with Alpha."
"Unfortunately, the vaccine’s beneficial effect on Delta transmission waned to almost negligible levels over time. In people infected 2 weeks after receiving the vaccine developed by the University of Oxford and AstraZeneca, both in the UK, the chance that an unvaccinated close contact would test positive was 57%, but 3 months later, that chance rose to 67%. The latter figure is on par with the likelihood that an unvaccinated person will spread the virus."
>Arguments like "clearly fail to control the spread" are low effort Gish Gallops that need to be treated as such.
The failure to control the spread has been obvious for at least half-a-year for anybody doing simple arithmetic on public numbers (and like others i have commented on that as far back then). Now beside being obvious, it is also confirmed by a proper scientific publication
https://www.nature.com/articles/d41586-021-02689-y
" A person who was fully vaccinated and then had a ‘breakthrough’ Delta infection was almost twice as likely to pass on the virus as someone who was infected with Alpha."
"Unfortunately, the vaccine’s beneficial effect on Delta transmission waned to almost negligible levels over time. In people infected 2 weeks after receiving the vaccine developed by the University of Oxford and AstraZeneca, both in the UK, the chance that an unvaccinated close contact would test positive was 57%, but 3 months later, that chance rose to 67%. The latter figure is on par with the likelihood that an unvaccinated person will spread the virus."
At first I expected the advent of mass vaccination to end the pandemic, because it only had to drop R by a factor of two or so to drop below the critical percolation threshold, so even a vaccine providing 50% sterilizing immunity would be good enough, and the mRNA vaccines turned out to be even more effective than expected. I turned out to be spectacularly wrong about that; as you may or may not be aware, the pandemic did not end a year ago. It turned out that, unlike vaccines like the smallpox vaccine, the covid vaccines did not provide much sterilizing immunity.
Moreover, the virus has become endemic in a number of zoonotic reservoirs, including deer, feral cats, and some mustelids, and vaccinating or exterminating those populations is not realistic in the next few decades. This is not currently a significant source of human outbreaks as far as I can tell, but after the humans reach herd immunity, it will be the only one.
Consequently, the cost-benefit tradeoff for covid vaccinations with the currently available vaccines needs to be evaluated with respect to the benefit to the person being vaccinated. I'm glad I'm vaccinated: as an obese 45-year-old man, my risk of death from covid might approach 1%, which is enormously higher than any plausible risks from any of the vaccines I'm familiar with. But that tradeoff is not the same for everyone, and there are populations where the rate of death or permanent harm from a vaccine, though still extremely low, is likely higher than the rate of death or permanent harm from covid itself.
The situation would be different if, for example, vaccinating schoolchildren prevented them from infecting and inadvertently killing their grandparents. But it doesn't. So the fact that the existing vaccinations clearly fail to control the spread is extremely relevant to the cost-benefit tradeoff, in particular because it means that there's no valid public-interest argument for requiring people to get vaccinated. Since both the cost and the benefit flow to them individually, they should be able to make the decision individually, except in cases such as small children and comatose patients.
This is an argument that deserves rational consideration, not dismissal with mindkiller phrases like "vapors" and "anti-vax". That's the sort of argument, or rather non-argument, that "deserves to lose".
Moreover, the virus has become endemic in a number of zoonotic reservoirs, including deer, feral cats, and some mustelids, and vaccinating or exterminating those populations is not realistic in the next few decades. This is not currently a significant source of human outbreaks as far as I can tell, but after the humans reach herd immunity, it will be the only one.
Consequently, the cost-benefit tradeoff for covid vaccinations with the currently available vaccines needs to be evaluated with respect to the benefit to the person being vaccinated. I'm glad I'm vaccinated: as an obese 45-year-old man, my risk of death from covid might approach 1%, which is enormously higher than any plausible risks from any of the vaccines I'm familiar with. But that tradeoff is not the same for everyone, and there are populations where the rate of death or permanent harm from a vaccine, though still extremely low, is likely higher than the rate of death or permanent harm from covid itself.
The situation would be different if, for example, vaccinating schoolchildren prevented them from infecting and inadvertently killing their grandparents. But it doesn't. So the fact that the existing vaccinations clearly fail to control the spread is extremely relevant to the cost-benefit tradeoff, in particular because it means that there's no valid public-interest argument for requiring people to get vaccinated. Since both the cost and the benefit flow to them individually, they should be able to make the decision individually, except in cases such as small children and comatose patients.
This is an argument that deserves rational consideration, not dismissal with mindkiller phrases like "vapors" and "anti-vax". That's the sort of argument, or rather non-argument, that "deserves to lose".
> after the humans reach herd immunity
That doesn't appear to be on the cards; neither vaccines nor actual infection confers immunity, in either case you only get resistance. And if you can't get individual immunity, talk of herd immunity is silly.
COVID is going to be endemic.
My hope is that omicron confers cross-resistance to other variants. From what I've heard, an omicron infection is nastier than a bad dose of 'flu, but much less nasty than infection with delta. With omicron's extreme success at transmission, perhaps omicron will give the whole world a degree of resistance to all COVID variants, and endemic COVID will eventually become no more scary than endemic adenovirus.
That doesn't appear to be on the cards; neither vaccines nor actual infection confers immunity, in either case you only get resistance. And if you can't get individual immunity, talk of herd immunity is silly.
COVID is going to be endemic.
My hope is that omicron confers cross-resistance to other variants. From what I've heard, an omicron infection is nastier than a bad dose of 'flu, but much less nasty than infection with delta. With omicron's extreme success at transmission, perhaps omicron will give the whole world a degree of resistance to all COVID variants, and endemic COVID will eventually become no more scary than endemic adenovirus.
Immunity and resistance are the same thing, not two separate things. Total immunity ("sterilizing immunity") is relatively unusual, and doesn't seem to exist for covid, but covid immunity seems to last for at least several months, maybe a year or more, at high enough levels to prevent epidemics ("herd immunity"). Given how fast O spreads, it seems likely that it will burn itself out among the humans in a few months --- but covid will probably always be able to come back from the zoonotic reservoirs.
I hope you're right about the scariness, but I worry about the incidence of "long covid", and in particular the possibility of widespread organ damage from blood clots.
I hope you're right about the scariness, but I worry about the incidence of "long covid", and in particular the possibility of widespread organ damage from blood clots.
Bad premise. It is not all about benefit to the person being vaccinated even in a low imputed immunity scenario. The unvaccinated fill up and overwhelm healthcare systems. That disrupts all medical care for everyone. By being vaccinated you are reducing the burden for everybody.
You may have a point there, but I think it would be a stronger point if you were advocating prohibiting something like rock climbing or motorcycle riding during the pandemic, because the absolute risk that a young, healthy person will end up in the hospital due to covid is just so much lower than those activities. It's a quick slippery slope to prohibiting physical inactivity that could produce obesity.
>The unvaccinated fill up and overwhelm healthcare systems. That disrupts all medical care for everyone. By being vaccinated you are reducing the burden for everybody.
That argument just doesn't hold the water. Most people don't reduce that burden by being vaccinated because they weren't such a burden to start with. For the most people the probability of hospitalization is so low that vaccinating them results in the practically undetectable changes to the total hospitalizations. High-risk groups is a different story. Vaccinating them does change the hospitalizations number.
So far - the available vaccines fail to control the spread, and those vaccines for most people fail to affect hospitalization numbers. So, what is the rationale for the vaccination mandates?
Note - it is the core of democracy that a limitation of personal body rights should be accompanied by a well founded reason of public interest. For the vaccination mandate that would be a scientifically sound conclusion of limit of spread for example or even say meaningful effect on the hospitalizations numbers. So far the vaccination mandate side has failed to provide any such scientifically sound reason. That makes the vaccination mandate to be an unreasonable authoritative action of gross violation of basic personal rights.
That argument just doesn't hold the water. Most people don't reduce that burden by being vaccinated because they weren't such a burden to start with. For the most people the probability of hospitalization is so low that vaccinating them results in the practically undetectable changes to the total hospitalizations. High-risk groups is a different story. Vaccinating them does change the hospitalizations number.
So far - the available vaccines fail to control the spread, and those vaccines for most people fail to affect hospitalization numbers. So, what is the rationale for the vaccination mandates?
Note - it is the core of democracy that a limitation of personal body rights should be accompanied by a well founded reason of public interest. For the vaccination mandate that would be a scientifically sound conclusion of limit of spread for example or even say meaningful effect on the hospitalizations numbers. So far the vaccination mandate side has failed to provide any such scientifically sound reason. That makes the vaccination mandate to be an unreasonable authoritative action of gross violation of basic personal rights.
That's straw-manning
I've also talked to the biohackers. S ome of them are smart, careful, and just get stuff done in the lab. Then there are the attention hogs who inject themselves on youtube (typically with no ability to know if they did anything at all), many of whom, after a few years, realize that what they are doing is naive, and that there was actually a reason for the entire establishment around pharma.