Consider that all options consists of exactly the same code change outcome.
Consider some reasonable average for lines of code changed by file that shouldn't affect your decision.
Consider that, for multiple PRs, each new PR can only be created after the previous is reviewed and merged.
Note that options with more PRs have less files changed per PR, but the total sum of the option is larger than an option with less PRs. This kind of assumes that in order to split a code change in multiple PRs you have to make some temporary changes that you will revert in later PRs (so more total changes than a single PR with the final desired outcome).
Consider some reasonable average for lines of code changed by file that shouldn't affect your decision.
Consider that, for multiple PRs, each new PR can only be created after the previous is reviewed and merged.
Note that options with more PRs have less files changed per PR, but the total sum of the option is larger than an option with less PRs. This kind of assumes that in order to split a code change in multiple PRs you have to make some temporary changes that you will revert in later PRs (so more total changes than a single PR with the final desired outcome).