Parental experience influences behavior and neural structure in generations(ncbi.nlm.nih.gov)
ncbi.nlm.nih.gov
Parental experience influences behavior and neural structure in generations
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923835/
2 comments
From the abstract:
> We subjected F0 mice to odor fear conditioning before conception and found that subsequently conceived F1 and F2 generations had an increased behavioral sensitivity to the F0-conditioned odor, but not to other odors. When an odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition F0 mice, the behavioral sensitivity of the F1 and F2 generations to acetophenone was complemented by an enhanced neuroanatomical representation of the Olfr151 pathway. Bisulfite sequencing of sperm DNA from conditioned F0 males and F1 naive offspring revealed CpG hypomethylation in the Olfr151 gene.
> In addition, in vitro fertilization, F2 inheritance and cross-fostering revealed that these transgenerational effects are inherited via parental gametes.
Fascinating implications. It will be interesting to see if this can be replicated.
> We subjected F0 mice to odor fear conditioning before conception and found that subsequently conceived F1 and F2 generations had an increased behavioral sensitivity to the F0-conditioned odor, but not to other odors. When an odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition F0 mice, the behavioral sensitivity of the F1 and F2 generations to acetophenone was complemented by an enhanced neuroanatomical representation of the Olfr151 pathway. Bisulfite sequencing of sperm DNA from conditioned F0 males and F1 naive offspring revealed CpG hypomethylation in the Olfr151 gene.
> In addition, in vitro fertilization, F2 inheritance and cross-fostering revealed that these transgenerational effects are inherited via parental gametes.
Fascinating implications. It will be interesting to see if this can be replicated.
The abuse of animals for absolutely nothing interesting or useful.
Reminds me of Skinner and Pavlov.
How about I pop round your house and force some fear conditioning on you muppet!
I bet that would influence your behaviour too.
Psychoanalysis already know this happens in humans with generational trauma, so why fuck up and abuse some poor mices to prove a point.
Muppets!