SDR42E1 modulates Vitamin D absorption and cancer pathogenesis(frontiersin.org)
frontiersin.org
SDR42E1 modulates Vitamin D absorption and cancer pathogenesis
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1585859/full
4 comments
If you’ve heard about a journal publishing an AI slop paper claiming they reviewed it, its the same journal we are seeing here.
That happened in Frontiers in Endocrinology?
Sadly Frontiers in Oncology is not better. Recently they published a meta analysis from „research institute” that pushes alternative cancer medicine written by people who have no domain education with no actual analysis of quoted research being done in the paper:
https://www.frontiersin.org/journals/oncology/articles/10.33...
https://www.frontiersin.org/journals/oncology/articles/10.33...
> SDR42E1 modulates vitamin D absorption and cancer pathogenesis: insights from an in vitro model
[If you're unfamiliar - "in vitro" basically means they're doing research with cells in test tubes - so no live animals, and no human subjects. And "SDR42E1" is a particular gene.]
> Nagham Nafiz Hendi,&#x;Nagham Nafiz Hendi1,2†Georges Nemer,&#x;Georges Nemer2,3†
> Introduction: Vitamin D is a pleiotropic hormone essential for bone health and overall physiological function. Despite its significance, vitamin D deficiency remains widespread and is often influenced by genetic factors.
> Methods: This study investigates the role of SDR42E1, a gene encoding a short-chain dehydrogenase/reductase enzyme, in vitamin D regulation and sterol metabolism. Using CRISPR/Cas9 gene-editing, we generated an SDR42E1 knock-in model in HCT116 colorectal cells, which exhibit high endogenous SDR42E1 expression, harboring a nonsense variant associated with vitamin D deficiency.
> Results: [...]
> Conclusion: These findings establish SDR42E1 as a key modulator of vitamin D-related pathways and highlight its potential as a therapeutic target for addressing vitamin D deficiency and associated pathologies, including cancer.