Definium's LSD-based depression pill delivers strong late-stage results(reuters.com)
reuters.com
Definium's LSD-based depression pill delivers strong late-stage results
https://www.reuters.com/business/healthcare-pharmaceuticals/definiums-lsd-based-pill-reduces-depression-symptoms-late-stage-trial-2026-06-22/
12 comments
Aldus Huxley was a proponent of LSD[0]. The Soma in his Brave New World is not meant to represent it.
[0] https://daily.jstor.org/when-aldous-huxley-dropped-acid/
[0] https://daily.jstor.org/when-aldous-huxley-dropped-acid/
Do other antidepressants, of which there are many, remind you of Soma as well?
pretty exciting if this passes FDA approval. it's getting close.
I'm going to skip the line on this one.
What is their dosing schedule? It says single dose, but how much are they giving?
It’s a single 100-microgram dose. It temporarily dampens the Default Mode Network (DMN), creating a "reset window" for the brain to rebuild its pathways. https://ir.definiumtx.com/news-events/press-releases/detail/...
How do you do a double-blind with a drug that perceptibly changes your state of mind?
I guess you do it anyway? the change in the state of mind is thought to be at least in part the mechanism of action, no? so if thats what makes it work, its good to test it against a non hallucinogen
You can't, and it's a real problem for some people. Other people realize that, like testing the efficacy of parachutes by throwing two people off an airplane, one without a parachute; other people realize the double blind standard can't be applied but that the results aren't woo mystical astrology unfounded conclusions despite that.
academia is struggling to realize this
What happens if I take 10?
Oh wait. That layoff caused my health insurance to quit working.
Oh well, can’t have any fun these days.
Oh wait. That layoff caused my health insurance to quit working.
Oh well, can’t have any fun these days.
Reminds me of Soma from “brave new world” by aldus huxley.
We’re only missing a way to generate some pre-conditioned humans and we’re pretty much done (birthrates are already falling anyway, no need for malthusian practices).