I am a current undergraduate student using TopHat software. My professor stated that he was unable to typeface using Latex for the class notes. This should be a feature if it hasn't been updated already.
Additionally, at my school there is a centralized online interface for professors and students to post notes, quizzes, updates about the course, grades, forum discussions etc. Myself and many students were upset when we had to pay for a 'premium' service which offered no features outside what was offered for free in all our other classes.
All I can say is in order for TopHat to impress STEM students they will have to be very creative in the features that they offer. Though they are sometimes liked by professors, interfaces like TopHat and McGraw-Hill/Pearson are almost universally seen as a rip off by students. Access to propriety notes isn't a feature when very few students pay for any textbooks in their STEM subjects.