Accelerationists may argue that the eroding of proper attribution and proof verification by humans is a meaningless short term struggle of a dying field.
Mathematics seems to be entering an era where human + machine maximizes performance, much like chess in the 1990s. However, imagine a future where even talented mathematicians are nothing but noise in the machine (as is the case in chess now). A future where AI generates and verifies proofs without humans in the loop. Where the mathematics may be beyond human comprehension.
In that future, does it matter that early career mathematicians are inhibited by these developments? Perhaps not. Programming faces the same issue. As AI crawls up the competence ladder, does it matter that fewer people have opportunities to develop the skillset of a senior engineer? Perhaps not.
Accelerationists may argue that the eroding of proper attribution and proof verification by humans is a meaningless short term struggle of a dying field.
Mathematics seems to be entering an era where human + machine maximizes performance, much like chess in the 1990s. However, imagine a future where even talented mathematicians are nothing but noise in the machine (as is the case in chess now). A future where AI generates and verifies proofs without humans in the loop. Where the mathematics may be beyond human comprehension.
In that future, does it matter that early career mathematicians are inhibited by these developments? Perhaps not. Programming faces the same issue. As AI crawls up the competence ladder, does it matter that fewer people have opportunities to develop the skillset of a senior engineer? Perhaps not.
"Generative AI is art. It’s irredeemably shit art; end of conversation."
I think most people cannot destinguish between "genuine" creativity and an artificial almalgamation of training data and human provided context. For one, I do not know what already exsists. Some work created by AI may be an obvious rip off of the style of a particular artist, but I wouldnt know. To me it might look awesome and fresh.
I think many of the more human centric thinkers will be disappointed at how many people just wont care.
Regarding point 2: I think most people cannot destinguish between "genuine" creativity and artificial almalgamation of training data and human provided context. For one, I do not know what already exsists. Some work created by AI may be an obvious rip off of the style of a particular artist, but I wouldnt know. To me it might look awesome and fresh.
Furthermore, I think many of the more human centric thinkers will be disappointed at how many people just wont care.
AI tools are here to stay. They will start to creep into everything, everywhere, all the time. Either you recognize the moment at which it becomes a significant disadvantage not to use them (I agree that moment is not now), or get left behind.
If you take the ambitions of robotics and AI companies seriously then what they are trying to create is the equivalent of unleashing 100 million cloned copies of the smartest and most well adjusted people you know upon the economy at a fraction of the cost. If they succeed it would absolutely reduce jobs significantly. In fact, its a little hard to imagine how the average Joe would have any economic value at all.
I'm a genetic engineer at a large pharma company. We corrected the HTT gene in patient derived iPSCs in the lab. The region is a long repeat sequence of which a section needs to be deleted. Because of this the locus is quite difficult to genetically engineer, since it is difficult to target just the diseased allele but not the wild-type allele.
Typical gene therapeutic approaches probably wont work, e.g. Cas9 (you'd need two cuts to delete the sequence), Base editors (cant delete sequence), prime editing (deletion is too large for standard prime editing).
You'd either need a template based system such as homologous recombination (too inefficient) or something like twin-prime editing, but good luck getting that to work on repeat sequence.
The transgene engineering is totally possible without a viral vector. We engineer cells all the time with recombinase based editing methods for targeted safe harbor insertion of transgenes https://www.nature.com/articles/s41551-024-01227-1. This stuff just permeates through the community slowly.