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SubiculumCode

7,124 karmajoined 10 anni fa
I am a neuroimaging scientist with expertise in autism, memory function, and brain development. I am also a part-time coder, part-time composer, and part-time table-top enthusiast.

Submissions

Another ICE threat visit: How did agents track down this critic on his vacation?

syracuse.com
6 points·by SubiculumCode·13 giorni fa·1 comments

TimyWind Sailing Game

tinywind.io
3 points·by SubiculumCode·27 giorni fa·0 comments

Popular Weight-Loss Drug Found to Slow Biological Aging in Landmark Human Trial

scitechdaily.com
2 points·by SubiculumCode·mese scorso·0 comments

HHS is overriding peer review to require changes to research scope, design

science.org
43 points·by SubiculumCode·mese scorso·37 comments

OMB's Proposed Federal Rules That May Destroy American Science

elizabethginexi.substack.com
6 points·by SubiculumCode·mese scorso·3 comments

Trump administration proposes NDAs for federal workers

reuters.com
10 points·by SubiculumCode·2 mesi fa·3 comments

Almost Every Angband Variant – Play Online

angband.live
3 points·by SubiculumCode·2 mesi fa·0 comments

[untitled]

1 points·by SubiculumCode·2 mesi fa·0 comments

AI Stupid Level: Independent monitoring fluctuations in AI model performance

aistupidlevel.info
3 points·by SubiculumCode·3 mesi fa·1 comments

What NIH Staff Can't Tell You–and Why That Matters

substack.com
5 points·by SubiculumCode·5 mesi fa·3 comments

The Crumbling Workflow Moat: Aggregation Theory's Final Chapter

twitter.com
1 points·by SubiculumCode·5 mesi fa·0 comments

Chinese Fishing Boats Form Sea Barriers

nytimes.com
15 points·by SubiculumCode·6 mesi fa·3 comments

How 150 Minutes over Caracas Rewrote the Physics of Global Power

substack.com
2 points·by SubiculumCode·6 mesi fa·0 comments

The Venezuelan Oil Narative Is Pure Theatre

renegaderesources.pro
23 points·by SubiculumCode·6 mesi fa·35 comments

Mostlymatter: A fork of Mattermost by Framasoft

packages.framasoft.org
66 points·by SubiculumCode·7 mesi fa·9 comments

Federal Shutdown Means More Grants Won't Be Reviewed This Cycle

31 points·by SubiculumCode·9 mesi fa·22 comments

Hegseth orders rare, urgent meeting of numerous generals, admirals

cbsnews.com
6 points·by SubiculumCode·10 mesi fa·0 comments

comments

SubiculumCode
·6 ore fa·discuss
I wonder. There has been some headway in getting decentralized training runs to work.
SubiculumCode
·6 ore fa·discuss
Sounds like another Chinese Op to me; Ensuring Chinese compliance would be incredible hard to enforce or to check.

Look, I am scared of where we are heading, but I cannot see how we can change the dilemma towards mutual cooperation unless, as humans tend to do, only react massively after something really bad happens.
SubiculumCode
·7 ore fa·discuss
So, at some point, will our devices connect to their corporate offices in any environment, even without providing access to your network, short of putting it inside a Faraday Cage?
SubiculumCode
·7 ore fa·discuss
Human: I specialize in tasks in which the correctness of my solution cannot be easily specified or checked. Truuuuussssttttt meeeeee.

I'm just saying, let's not get painted into that corner completely as a species :)
SubiculumCode
·13 ore fa·discuss
Its like we don't already show faces in fMRI experiments because we know that it will often activate the fusiform face area. Its just light years away from anything dangerous, that I am compelled, as a neuroscientist, to try to shake some sense into people. This is HN, but it feels like twitter on some topics.
SubiculumCode
·13 ore fa·discuss
A completely off-topic anecdote, then a completely unfounded fear based on a clear misunderstanding of this research. If companies ever start making us live in a MRI machine so they can reliably activate brain areas with certain stimuli, I think there is a bigger problem we are having.

Here is how I see it. This type of research helps us understand the brain, helps us do things like model potential surgery sites better (e.g. for seizure activity interventions). What it does not do is become the basis for mind reading.

Just so that you know that I am not totally unsympathetic to your apparent worldview, let me tell you how I think your concern might actually play out:

AI continues to get more powerful, and computer brain interfaces begin to move beyond EEG scalp electrodes, but begins to take the form or brain augmentation via integrating networked AI compute into implanted chips with electrode neural interfaces, where our brain's neurons and the neural interfaces learn to speak each other's language (i.e. integrate). I can actually see this happening within 20 years. At first, it would be our brain using this augmentation for greater intelligence, etc. However, remote manipulation of the interface could reverse control of brain activity, leading exactly to your fear.

But this research? This is light years from that,,,so much so that it is not even relevant to bring up unless you are just against all technology.
SubiculumCode
·13 ore fa·discuss
Oh you are right. Let's just end neuroscience altogether. Also computer science, aerospace, and biology in general. In fact, let's go full Amish. Wait, no. Someone might use a buggy cart to run people over.

What exactly is your new fear here?
SubiculumCode
·13 ore fa·discuss
yeah. This is one of those things where they used previously collected data, built a model that has validity on modeling validity between simulation and actual brain (encoding model for digital twin), then built a new model using the encoding model that tries to reliably activate particular brain regions. The next obvious step is to validate this back to the original person, but they will need to collect new data, and so likely, will need to get research funding. One step at a time.

The digital twin types of models will become more and more useful, but I don't think we will be at the point where all research will be done entirely within these models.

They can be fun to play with btw: https://www.thevirtualbrain.org/tvb/zwei/ and they don't require a beast of a machine to run.
SubiculumCode
·13 ore fa·discuss
A. Unless you think that brain science is immoral science, then I do not see any problem with this kind of research. As a neuroscientist, I strongly object to the insinuation as unfounded.

B. "Digital twins" e.g. [1] are a growing class of brain simulations that can successfully approximate brain activity patterns at large scale. I think these can be very useful, but we shouldn't think that they are at the level of actually simulating a brain. They are usually made of model neuronal approximative simulations (e.g. integrate and fire, balancing excitatory and inhibitatory neural populations within units), then using diffusion imaging to estimate white matter axonal wiring between those populations from the subject to increase the accuracy of the simulation. These are increasingly being used to, for example, model how a surgical intervention would effect seizure propagation prior to actual surgery. Here is a nice episode of Theoretical Neuroscience podcast [2] on the Virtual Brain [3], one of the available models for this kind of work.

C. In terms of validation. Only partly. From my quick read, this NEVO model optimized neural response only in the digital twin encoding model. While the digital twin model reportedly has solid predictive validity [4], which by the way was not the Virtual Brain model I mentioned in point B. Moreover, the outputs looked neurobiologically plausible, but at this point, there is no independent model or new fMRI showing the optimized stimuli actually drive the target regions. This was performed using previously collected fMRI data, and full validation of this model *IS* the obvious next step, but the money to collect such data does not come from nowhere: funding will be needed, and such a paper as this can help them get it.

D. A final point I'd make. We have long been able to create static stimuli that we can be fairly certain will activate above baseline certain brain regions, on average. Certain stimuli-region pairs ar emore homogenous between people, others e.g. the fusiform face area (FFA), are small enough that individual differences prevent a simple ROI approach, and identification depends on using face stimuli to identify at the individual level, but for the most part, it is reliably locatable. Brain activations are very coarse things. In fMRI, you are talking about ~3x3x3mm voxels (27mm^3) where the hemodynamic responses have a ton of spatial autocorrelation, or in EEG, where the surface spatial area of the reeptive fields are very large(~400 mm^2). These virtual twin models already do a decent job of modeling dynamics of the brain there parameters are tuned to *at this scale*..but this scale does not have a ton of information content. Automating this with video content is not that much a reach.

[1] https://spj.science.org/doi/10.34133/icomputing.0055 [2] https://theoreticalneuroscience.no/thn23/ [3] https://www.thevirtualbrain.org/tvb/zwei/ [4] https://www.biorxiv.org/content/10.1101/2025.07.22.664908v2....
SubiculumCode
·ieri·discuss
Ahh, I remember hearing that before, and it makes general sense too.
SubiculumCode
·ieri·discuss
Excuse my ignorance. Could one just say, "One expert is all I can handle" and strip the others from the model?
SubiculumCode
·ieri·discuss
thank you.
SubiculumCode
·l’altro ieri·discuss
The US was not brought down to its knees. That is propaganda speaking, not reality. Jeez.
SubiculumCode
·l’altro ieri·discuss
I sometimes wonder if they are leaving their best models for purely internal use. They are after regular users, integration locking with their full stack lock-in...having the best AI public might not add much to that play...just good enough for most people...while their internal models can help their company achieve faster production.. idk
SubiculumCode
·l’altro ieri·discuss
the title was flamebait, but its true for him...and for me. I do neuroimaging. It won't answer any question / coding task having to do with data analysis / statistical analysis. etc. It IS useless, for me.
SubiculumCode
·l’altro ieri·discuss
I absolutely have been unable to use Fable for any neuroimaging work. Its fine. The other models are good enough, honestly...and while I AM annoyed that the filter is so broad, I also understand it, as I do believe that models can become dangerous as WMDs, eventually. Still, it is completely useless for me.

The only question I had was being flagged for other reasons, so I asked it a mechanical engineering question, and it was just fine with that.
SubiculumCode
·3 giorni fa·discuss
Funny, the cheerleading at HN for leading Chinese models, but a non Chinese lab (building on top of a Chinese model) gets dissed here.
SubiculumCode
·3 giorni fa·discuss
Link for this?
SubiculumCode
·3 giorni fa·discuss
Up and out the back door, any 'ol time.
SubiculumCode
·3 giorni fa·discuss
kokoro is very nice, but I am disappointed that this wasn't an announcement of a new kokoro version.