One of the contributors here - not entirely sure if you're asking for pros or cons, but the entire point of Caldera is to execute/keep the React code on the server and only stream DOM updates. It's set up such that existing React web apps can be easily ported over (essentially just move all client logic to the server), so you can definitely make normal web apps with the framework! If you're asking about drawbacks, one of the biggest issues is latency, since events need to be sent to the server to be processed, but this can be relatively easily alleviated by hosting servers closer to clients.
Definitely want to take the time to throw out a huge recommendation for FBN (Farmers Business Network), a KPCB/Google Ventures backed startup that's doing really cool work in data analysis + aggregation + insights for farmers.
For the sake of clarity, I was an intern there, but I objectively think that their approach is very insightful and hits a lot of key points that many ag startups get wrong. Two of my biggest personal takeaways were that obsession with farm yields doesn't actually translate very well to increased profits, because there are so many other factors and costs (and risk) in farm operations. Furthermore, because of all these other operations (e.g. researching better seed varieties, buying inputs, loans in order to buy inputs and hope that they can be repaid later when harvest time comes), there is a huge need to address pervasive and complex issues with regards to the entire farming enterprise, not just the yield portion. FBN does a really great job at tackling the holistic approach, which I think really helps increase the effectiveness of FBN's product and makes it a really powerful tool.