What popular intruments can be made to play microtunal / non-Equal tempermant without major modifications? Sitar, and fretless stringed instruments come to mind, but I wouldnt say "like physical instruments" because the culture of building musical tools is so heavily influenced by western musicians.
Do you feel that this isn't true? I was raised by musicians, and am an (amateur) musician. It rings true to my feelings and experiences. It not just our software but inside our hears and ears. We want to play and replicate what we hear and know and western musicians hear mostly western music, based on (but not exclusively on) 4/4, equal temperament.