I had acid reflux from the time I was 15 years old. By the time I was 22 it had eaten holes almost through my esophagus, so I had Laparoscopic Nissen fundoplication surgery. They basically wrapped part of my stomach around the valve and it tightened it up. No more heartburn.
On the down side, I no longer can vomit, so there's that. (Confirmed after the not-so-smart decision to try every booth at a chili cook-off.)