The way these type checkers get fast is usually by not supporting the crazy rich reality of realworld python code.
The reason we're stuck on mypy at work is because it's the only type checker that has a plugin for Django that properly manages to type check its crazy runtime generated methods.
I wish more python tooling took the TS approach of "what's in the wild IS the language", as opposed to a "we only typecheck the constructs we think you SHOULD be using".