One good timesaver: debug in the easiest environment that you can reproduce the bug in. For instance, if it’s an issue with a website on an iPad, first see if you reproduce in chrome using the responsive tools in web developer. If that doesn’t work, see if it reproduces in desktop safari. Then the iPad simulator, and only then the real hardware. Saves a lot of frustration and time, and each step towards the actual hardware eliminates a whole category of bugs.