greygoo222

17 時間前議論

I am referring to t.me/hackernewslive, 27k subscribers. This post was reposted on Telegram within 2 minutes of it going live on HackerNews, when it still had <5 upvotes, so I feel there has to be either some manual or LLM-driven curation here, or something else.

greygoo222

17 時間前議論

Who runs the HackerNews Telegram channel? I used to think they had some algorithmic repost script that grabbed top posts, but this is a 5 minute old post by a low-karma account and it got posted to Telegram.

greygoo222

18 時間前議論

The world is so big, why spend 40 years in a single place?

greygoo222

3 日前議論

It's like the people writing this shit have never been a teenager. I feel like an old man yelling at clouds, but damn, the internet was so much less sanitized when I was 13 and we were happy for it.

greygoo222

9 日前議論

Has anyone ever heard of this person? Why did this get posted?

greygoo222

19 日前議論

Leetcode/hackerrank problems aren't that high variance, dedicate a weekend studying and you should be good.

greygoo222

19 日前議論

I'm a new grad. It took me about three weeks to get two offers, both from cold applications. I applied to ~100 jobs in total and got first round interviews from 10% of the ones I cold applied to, much higher when I had an in.

I then, uh, turned both offers down because I thought the roles weren't interesting enough and didn't pay enough to make up for not being interesting (170k base). Now I am back in the process and, knock on wood, I am in the middle of final rounds with several companies and expect to have a much better offer by next week.

I have a background in ML and agentic systems, which did come up, but my resume isn't outstanding. No big tech or frontier lab internships, no published papers, no unicorn startup. I wouldn't say finding jobs has been easy, but it hasn't been remotely as difficult as this thread implies, and I believe the statistics back me up here. I suspect this is a "people who aren't struggling don't complain about it online" phenomenon.

Regardless, I wish everyone here best of luck in finding a job.

greygoo222

28 日前議論

Please name one "third world country" that enforces gender roles less harshly than the US, particularly the liberal US cities where gender diversity is the most common.

greygoo222

2 か月前議論

Utterly asinine article that doesn't understand its own subject matter.

greygoo222

3 か月前議論

https://en.wikipedia.org/wiki/Prohibition_in_the_United_Stat...

greygoo222

3 か月前議論

Can confirm.

The people behind the website asked a voice agent to program it, and the STT parsed "agent" as "asian."

greygoo222

3 か月前議論

If someone wants to take Ozempic for cosmetic reasons, that's their business. I am almost certain you personally indulge in riskier activities than using Ozempic, or... modafinil? You know people still use research chemicals, testosterone, and modafinil, right?

greygoo222

3 か月前議論

Depends on how they work. Many genes that are active during early development are entirely silenced throughout adulthood, or otherwise have no effect.

greygoo222

4 か月前議論

Quite a biased source, no? This doesn't provide evidence that these differences are biological. Boys are much more likely to exercise than girls due to social norms: https://pmc.ncbi.nlm.nih.gov/articles/PMC10478357/.

greygoo222

4 か月前議論

You can debate what policies are the most fair without calling trans women "men."

greygoo222

4 か月前議論

Transition changes biology. We don't yet have the technology to fully reverse the effects of male puberty, so there can be reasonable debate about trans women who transitioned after puberty, but early transitioners have no meaningful advantage. Their bodies, in an athletic context, are female.

This is also true for many cisgender intersex women with XY chromosomes. Someone with androgen insensitivity can have XY chromosomes, yet be capable of giving birth. Drawing the line at having a Y chromosome makes no sense.

greygoo222

4 か月前議論

You don't understand how the technology in question works, and you're just making shit up because you don't want to admit to being wrong.

What are you alleging here anyways? That all the scientists quoted and photographed in the article discussing their part in making the vaccine are in on the game? That the Australian made the story up wholesale? Come on.

greygoo222

4 か月前議論

He is not using an LLM in some new and exciting way. The process of making a personalized mRNA vaccine looks something like this:

1. Collect and sequence patient's normal and tumor genomes 2. Predict immunogenic neoantigens from genome 3. Generate optimized mRNA sequence from neoantigens 4. Create vaccine from sequence

modulo some variations, which I wrote off the top of my head because I understand this technology.

Steps 1 and 4 are done by contracted labs. Steps 2 and 3 are doable through open-source computational tools and a little engineering. What does ChatGPT do here? ChatGPT explains the process, finds labs that will do 1 and 4 for pay, finds published algorithms and data for steps 2 and 3. It's barely more complicated than what ChatGPT would do to help a student with their homework.

Legal documents, on the other hand? Have you ever tried to get an LLM to do your taxes? It's not easy.

greygoo222

4 か月前議論

Have you ever tried writing a long, complicated document with an LLM? The last 20% takes 99% of the work.

greygoo222

4 か月前議論

ChatGPT did not make the treatment. ChatGPT summarized literature explaining how to make similar treatments, and then specialized tools were used to make the treatment. It is perfectly reasonable that ChatGPT can summarize literature and not make compliant 100 page legal documents.

The principle behind personalized mRNA vaccines is simple enough, and it's perfectly plausible that someone with money and lab access can create an effective treatment not offered through conventional means. It would be plausible even for a human patient right now, with mRNA vaccines still hung up in clinical trials. For a dog? Of course.

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