Hey mate for what it's worth and you might say not much and may be right, the argument I ear goes as follow: the trials showing the ineffectiveness of HCQ use protocols that are inconsistent with the protocols the advocate of HCQ propose.
To my understanding, the proponents tend to say that HCQ is effective when administered as soon as first symptoms (day 0 to 3 I believe). There are also dosage issues and combinations with other drugs, and they say that HCQ is ineffective administered late.
In the first paper you propose, patients treated are already hospitalized (day 14 or fewer still probably not day 0 to 3). The fourth paper states (when following the link the to protocol) that hospitalisation is a condition for eligibility. That's not first symptoms.
The third papers talks about "initiated medication a median of 5.9 days after symptom onset". So not 0 to 3 days?
The second paper you propose talks about administering HCQ as post-exposure prophylaxis. It seems outside of the scope to me.
There are other issues on this debate, dosage, drug combinations, I can't talk about that, this website does:
To my understanding, the proponents tend to say that HCQ is effective when administered as soon as first symptoms (day 0 to 3 I believe). There are also dosage issues and combinations with other drugs, and they say that HCQ is ineffective administered late.
In the first paper you propose, patients treated are already hospitalized (day 14 or fewer still probably not day 0 to 3). The fourth paper states (when following the link the to protocol) that hospitalisation is a condition for eligibility. That's not first symptoms.
The third papers talks about "initiated medication a median of 5.9 days after symptom onset". So not 0 to 3 days?
The second paper you propose talks about administering HCQ as post-exposure prophylaxis. It seems outside of the scope to me.
There are other issues on this debate, dosage, drug combinations, I can't talk about that, this website does:
https://hcqmeta.com/
This person resumes the argument this way:
https://roundingtheearth.substack.com/p/how-to-rig-research-...
(Note that the fourth paper on your list is the RECOVERY trial he's no a fan of)
What do you think about this? Also what about intelligent design?