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mac-mc

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mac-mc
·7 か月前·議論
Dude, disclose the AI writing; it has AI smells all over it, such as contrastive sentences.
mac-mc
·8 か月前·議論
No, I mean for some, a high saturated fat diet can do amazing wonders. And for others, it causes horrible issues. The studies are not well segmented genetically and by body state since that is signficantly more expensive and genetics only got cheap in the past 10 years or so, so they wash out these large sub-population dynamics.
mac-mc
·8 か月前·議論
Different countries are different, some are far more trigger happy about it like Canada. What you suggest as an alternative other than 'git gud' diet & exercise also changes it.
mac-mc
·8 か月前·議論
I've tried designing information-dense things for colorblind coworkers, and they seemed a bit disinterested in testing it out with me. Even with tools that simulate it, you can still be off, I've found.

There can be some sensitivity about trying to figure it out with them. I've added little affordances here and there, and ironically, I rely mentally more on color coding things because I am bad at finding things in a visual field than most.

I've also found that colorblind family members and friends just never tell you and they tend to suffer in silence. Even my own half-brother (which I have a 15 year gap with) didn't tell me he was colorblind until recently.
mac-mc
·8 か月前·議論
17 years is far from rapid or move fast and break things. ApoB has been known about for quite a long time, since the 90s its effects have been obvious, and showed up in research in the 70s-80s!!! It's still not part of standard testing!!!

Guidelines also leads to standards of care being random and heavily driven by politics & financial reasons disguised as medical best practice. South Korea and India are "parallel testing" places, which saves time, while the USA & others are serial testing places mostly because of their funding models.

Talk to any American doctor and they will give you a bunch of emotionally wrapped cope about why it's bad because the cognitive dissonance sucks and there are liability reasons to avoid admitting your wrong. I would argue that in many cases, parallel testing is cheaper because $300 of tests is cheaper than 4 chained $500 doctor visits. But whatever.
mac-mc
·8 か月前·議論
If you dig into research and follow the low-risk experiments that people do online to reduce their Lp(a), you can find techniques and evidence to do so. It doesn't have to be an impossible-to-fix issue.

I like this list of experiments by Greg Muschen: https://x.com/gregmushen/status/1924676651268653474
mac-mc
·8 か月前·議論
If you fix it without statins through better lifestyle and diet, that is the preferrable route.

As to why medicine is like this, it's because it's conservative, usually about 17 years behind university research[0], and doctors are shackled to guidelines in most health systems or risk losing their licenses. It isn't a coincidence that the article author had his out-of-pocket concierge doctor tell him the more up-to-date stuff.

[0] https://pmc.ncbi.nlm.nih.gov/articles/PMC3241518/
mac-mc
·8 か月前·議論
IMO, I think that is more of a saturated fat issue, and only a subset of the population is like that. Others solve their health issues through eating a lot of red meat.
mac-mc
·9 か月前·議論
It's a fairly useful tool if you know how to use it. People will also play with it as a toy. It's much like the masses getting access to cheap video cameras and smartphones with good cameras. It's going to enable different content, it's not going to make more hollywood movies. This is an early example of what people will make: https://www.youtube.com/watch?v=jBwluRXtS2U . It's just one person making all of this on the side.
mac-mc
·9 か月前·議論
Yes, much like wet streets are a high predictor of rain. Or smoke, firefighters and wood are a high predictor of fire. The firefighters are not causing the fire, neither do the wet streets cause rain. This is what people are trying to tell you. If you remove the firefighters only, then you might make it worse. If you do something to cause the firefighters to go away, probably because there isn't a fire anymore, then you did the right thing. The important thing is not to goodhart's law yourself into doing the wrong thing.
mac-mc
·9 か月前·議論
Don't you sign something to the effect that you have not hidden testing like this that you are aware of?
mac-mc
·9 か月前·議論
Cholesterol is more of a proxy "smoke" or "firefighter" measure than a measurement of the actual fire. It's very much a wet streets cause rain kind of thing.

Artificially eliminating the firefighters doesn't necessarily mean you've solved most of the problem.

Heart disease is a far more complicated problem than "cholesterol" or "cholesterol + inflammation", but humans and patients mentally gravitate to silver bullet thinking, which makes it really hard to work with. One interesting measure I've encountered is the lipid clearance rate, but it costs something like +$20k to measure and is not something a doctor can order from a lab; it's typically only performed in research settings.
mac-mc
·10 か月前·議論
It is ultimately a form of insecurity.
mac-mc
·10 か月前·議論
ok what is DMV, RTP is research triangle park from what I can see. DMV is unsearchable.
mac-mc
·10 か月前·議論
I was the manager in this case, and I also hated JIRA with a passion. It's often the managers doing the alternative spreadsheets too and only using JIRA as necessary. I found you didn't need to "hound" developers with Phabricator and part of the hounding was me being hounded further up about it. Tools matter! Developers love automated organization!
mac-mc
·10 か月前·議論
JIRA is so dysfunctional in many places that people do a good chunk of intra-team planning in spreadsheets and docs instead, and use JIRA sparingly to make everyone faster.

I saw this effect live at my previous big tech after they moved to JIRA. JIRA got used way less than Phabricator because of all the friction it introduced and a lot more informal google docs + slack bot usage increased instead.

I remember to this day asking a report to plan more stuff in JIRA and seeing a beautiful task tree in Phabricator they did in the past. I asked why, and he shrugged and said it was just easier. That's when it really clicked for me. Linear can't come soon enough and burn JIRA to the ground.
mac-mc
·10 か月前·議論
IMO you need all types. A well-functioning team has people with different strengths that can get pathological when they go too far, and they cover for each other's strengths. The "just do it" high work ethic guys like that are great, but they can sometimes "just do it" in the wrong direction and don't stand back and ask if we should even do these things. "Mr. strategic" can sometimes stand back a bit too much and overthink things, etc.