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noleary

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投稿

Pac-832: A New Drug for Alzheimer's Disease

pacepharmaceuticals.com
2 ポイント·投稿者 noleary·14 日前·1 コメント

Building a custom octocopter from scratch with no prior hardware experience

karolina.mgdubiel.com
418 ポイント·投稿者 noleary·14 日前·91 コメント

World-first: therapy to make cells young again trialled in a person

nature.com
2 ポイント·投稿者 noleary·24 日前·0 コメント

Mark Zuckerberg Orders His Employees to Have Fun Again

gadgetreview.com
7 ポイント·投稿者 noleary·24 日前·2 コメント

Researchers Design and Build First Artificial Protein (2003)

hhmi.org
3 ポイント·投稿者 noleary·2 か月前·0 コメント

Temu is advertising filet mignon on X

twitter.com
58 ポイント·投稿者 noleary·2 か月前·17 コメント

How the Blitz enhanced London's economy

blogs.lse.ac.uk
3 ポイント·投稿者 noleary·2 か月前·1 コメント

Mike: open-source legal AI

mikeoss.com
209 ポイント·投稿者 noleary·2 か月前·113 コメント

Devil worshippers are using AI, exorcists are warned

thetimes.com
5 ポイント·投稿者 noleary·3 か月前·0 コメント

American Exchange Group to buy sneaker maker Allbirds for $39M

reuters.com
2 ポイント·投稿者 noleary·3 か月前·0 コメント

Sycophantic AI decreases prosocial intentions and promotes dependence

science.org
4 ポイント·投稿者 noleary·4 か月前·1 コメント

Building FireStriker: Making Civic Tech Free

firestriker.org
139 ポイント·投稿者 noleary·4 か月前·27 コメント

Ant Chat

baothiento.com
15 ポイント·投稿者 noleary·4 か月前·7 コメント

Tome: Open-source documentation platform with Markdown

github.com
9 ポイント·投稿者 noleary·4 か月前·1 コメント

Spacetime DB: running a live video call over a database

twitter.com
2 ポイント·投稿者 noleary·4 か月前·0 コメント

America has a tungsten problem

noleary.com
205 ポイント·投稿者 noleary·5 か月前·201 コメント

Frog 'saunas' could help endangered species beat a deadly fungus (2024)

science.org
26 ポイント·投稿者 noleary·5 か月前·4 コメント

US Supreme Court to decide if the pesticide Roundup is shielded from lawsuits

nytimes.com
7 ポイント·投稿者 noleary·6 か月前·0 コメント

The industrial waste site that glitters like a glacier

nationalgeographic.com
2 ポイント·投稿者 noleary·6 か月前·0 コメント

Vanderbilt University plans new campus in San Francisco

wsj.com
18 ポイント·投稿者 noleary·6 か月前·15 コメント

コメント

noleary
·2 か月前·議論
There've been some interesting new developments in cell therapies over the last few years. Bemdaneprocel from BlueRock Therapeutics is now into Phase 3 trials for Parkinson's, for example. The essential idea is to implant some dopaminergic neuron precursors to grow new cells in place of cell death. Still a long way from the kind of general stroke treatment you're describing, but regenerative neuroscience is looking pretty promising.

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[1] https://www.bluerocktx.com/bluerock-therapeutics-announces-p...
noleary
·4 か月前·議論
Also linking here the creator's broader portfolio: https://www.baothiento.com/
noleary
·4 か月前·議論
Seems to be changing the .org to a .com

https://firestriker.org/blog/building-firestriker-why-im-mak...

--

related, author is a friend with a less active HN account https://news.ycombinator.com/user?id=blakeofwilliam
noleary
·5 か月前·議論
> If you build apps with a lot of traffic, you know the first thing to break is the database.

Just out of curiosity, what kinds of high-traffic apps have been most interested in using PgDog? I see you guys have Coinbase and Ramp logos on your homepage -- seems like fintech is a fit?
noleary
·5 か月前·議論
FYI, Tungsten prices are quoted in metric ton units (MTUs) [1], which surprisingly aren't metric tons. They're actually 1% of a metric ton -- or 10kg. [2] So the price of Tungsten is actually 100x that.

[1] https://www.fastmarkets.com/metals-and-mining/minor-metals/t...

[2] https://quoteddata.com/glossary/mtu/
noleary
·5 か月前·議論
I'm not smart enough to stake an opinion on the viability of fusion. I pretty much only have high school mechanics and Wikipedia in my toolkit.

I can only ever make material conditional claims about things like this :)
noleary
·5 か月前·議論
Hey, I wrote the article. This is my personal website that I wrote mostly over the weekend.

I went down a rabbit hole reading about metals and mining and just thought it was interesting. Not an expert or a nefarious actor, unfortunately.
noleary
·5 か月前·議論
Reserves means something specific in the context of minerals! Reserves measure 'economically viable' deposits. [1]

There used to be tons of tungsten mines in the USA, e.g. in Colorado linked below.

[1] https://resourcecapitalfunds.com/insights/rcf-partners-blog/...

[2] https://coloradogeologicalsurvey.org/publications/tungsten-m...
noleary
·6 か月前·議論
https://archive.md/zqPZA
noleary
·6 か月前·議論
> We responsibly disclosed this vulnerability to Notion via HackerOne. Unfortunately, they said “we're closing this finding as `Not Applicable`”.
noleary
·6 か月前·議論
Related: https://news.ycombinator.com/item?id=46527706
noleary
·9 か月前·議論
It's not that uncommon to keep the "CTO" title and not be the primary manager of the engineering organization. There are all kinds of things you can do with the org chart. If I recall correctly, Clickhouse works this way.

The company's cofounders comprise three people [1]:

* Aaron, a sales-oriented CEO from Elastic and Salesforce

* Alexey, the original Clickhouse developer, as CTO

* Yury, an experienced engineering executive from Google/Netflix as "President"

An excerpt from the launch announcement [2]:

> While negotiations were still ongoing, Katz decided they needed a third co-founder. “I kept thinking, if I could get a third co-founder to run product and engineering, and if I could find someone with the same level of experience building distributed systems on open-source that I have on go-to-market, it could be a really compelling combination,” Katz says.

---

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[1] https://clickhouse.com/company/our-story

[2] https://www.indexventures.com/perspectives/the-fast-and-the-...
noleary
·10 か月前·議論
Ontario Teachers' is a pretty active principal in venture/growth financings and a major LP to a bunch of funds. That said, venture/growth is a pretty small percentage of their holdings.

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[1] https://www.crunchbase.com/organization/ontario-teachers-pen...

[2] https://www.otpp.com/en-ca/investments/our-investments/teach...