Well done team Lithuania! Remember hearing Pixelmator founders giving a speech ~12 years ago. They were very vocal and repeated this many times: "Our marketing strategy is to just focus on the product". Not sure I agree with that statement, but they sure seem to followed it thoroughly. Congrats on the acquisition!
"I guess you could still have multiple Hono-based packages that handle segments of your backend" -> I am thinking the same - if you hit bundle size problems, you can just split your app.
I'd also love to see some benchmarks how bigger bundle size impacts the performance - i.e. 1 MB adds additional 1ms on average, or so... My platform of interest is mostly Cloudflare Workers.