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dumb1224

254 karmajoined 6년 전
curious about new trends and other distractions besides work-related technologies

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dumb1224
·5일 전·discuss
[dead]
dumb1224
·5일 전·discuss
The definition of haplotypes is definitely incorrect am I misunderstanding anything?
dumb1224
·13일 전·discuss
Exactly. Old parts of the system will be working if you leave them undisturbed. Mechanics have very good intuitions of this sort of thing.

I read about before there's proper engineering / physics theory about this too, it's like a car as a machine is a linear/smooth physics system with multiple weaknesses. Overtime longtime period of running many places might weaken but it still evolves into a slightly different smooth system, until you introduce a replacement which cause a mis-match of impedance or something like that.
dumb1224
·13일 전·discuss
Depending on the disease, even in cancer there's myeloma which may cause bone metastasis in many parts of the body with very focal lesions. Radiologists can't assess each and an every one of them, or even to find them all. So AI can definitely help in these scenarios.
dumb1224
·13일 전·discuss
I tried that AI diagnosis for my 15 old Ford C MAx too, however with a diagnostic problem the issue is unless you've got the ground truth, there's simply no way to verify any tool / human with a metric that you can compare and decide on future tasks.

The AI might be very good at diagnosing all minor issues, but might not lead to a successful repair, whereas human mechanics are extremely good on 80% of major issues that's not the ground truth, but will lead to successful repairs (that might not address the root but simply patch it). So it comes down to manage expectation / outcomes.
dumb1224
·지난달·discuss
I don't think it's anyone (lay person)'s fault. As a chinese person moved to European in the early 2000s for the longest time I wouldn't touch a chinese product (although I'm very proud of the progress made in terms of industrialisation).

Things changed in 2012 when I bought a 'cheap-ish' Huawei phone, it was nothing of a flagship, no performance but it was really solid product. Very light and well built too. How ironic that was my first ever experience of buying a product exported to Europe.
dumb1224
·지난달·discuss
High amount variance of quality is a daily reality and as any chinese consumer we are very used to that since the beginning of e-commerce. However there are multiple aspects to the quality feel. Production of high quality items is one thing (e.g one can do better QA etc), what I heard from some local car garages in China is that standardisation in the industry is still quite poor. E.g Parts to replace and bolts and nuts are not as standardised say as the German counter parts (purely from a mechanics point of view).

Having said that a lot of German car suppliers are in China, and the German car manufacturing industry evolved over a significantly longer period of time.
dumb1224
·2개월 전·discuss
Probably morden production. When I was a kid in the 90s he's a giant figure in the books taught often in school (his birthplace is very close to my city too which makes him a local national hero) and well known as model figure. But not anything in the media. Maybe even earlier times before me.
dumb1224
·4개월 전·discuss
It used to be a lot of them roaming in the residential area, out of necessity since household items were precious. Related is also the profession of a tinker to mend woks and pots and the scissor sharpener https://donwagner.dk/tinkers/tinkers-Zhongwen.html

Used to hear their shout in the street but largely disappeared in the 90s.
dumb1224
·4개월 전·discuss
I did my CS undergrad in China but was already in the UK early 2000s. I was also abit surprised there's little mention of TCP/IP which is kinda considered classics if there's anything taught in CS at all. Java was definitly the new dominating force in industry and academia at that time.

However it depends on the resources the univ got. In some places there were other less Comp sci / software engineering focused degrees but got a little content overlap (I guess for financial benefits to enroll more students) such as e-commerce / digital degrees. They shared some courses with CS but not all.
dumb1224
·5개월 전·discuss
> The art of Hendrix's playing, then, is partly in how he harnessed that sound and integrated it into his voice. And of course, he's a force of nature when he does so.

One thing for me to notice is his playing does not require a rhythm guitarist. I discovered that what worked well is Mitch Mitchell as a Jazz drummer his playing was heavily influenced by classics. In a way it complemented Jimi's guitar tone so well.
dumb1224
·5개월 전·discuss
I got the area wrong. Greater London is apparently 1500 km^2 so the total area of my administrative city is 4 times the size of that (with a total population of 3.4 mil)
dumb1224
·5개월 전·discuss
Forgot to add context, my hometown is under zhejiang province (as different regions have different population structures).
dumb1224
·5개월 전·discuss
It's a common source of confusion. The administrative definition of a 'city' is the equivalent of its metropolitan area + all satelite 'towns' and their suburbs (including farm lands).

My hometown has a population of 3.4 million (prefecture level city or 3rd tier as people call it). But it has an area about 6000 km^2, easily reaching the total size of London. At its core the central town has roughly a population of 700,000. And there are 4 more towns after the central one, each has smaller villages and suburbs under them. People living in these towns wouldn't consider they are living in the same city.
dumb1224
·6개월 전·discuss
Yes it's only relevant if you know the reference at that time. The day today and the other satire shows aimed to follow certain general formula though so even if it's not funny for some its archetypical characters still fit in that genre of comedies in my opinion.
dumb1224
·6개월 전·discuss
True that. So it's down to our preferences : )
dumb1224
·6개월 전·discuss
Well depending on your taste of TV shows and the general culture.

When I moved to the UK early 2000s I could understand but can't appreciate that type of humour. I think its rooted in culture. Luckily that was the golden era of British comedies and there were great diversities so you can pick and choose what flavour you like.
dumb1224
·8개월 전·discuss
Tumour evolution and progression is complex, being diagnosed early does not guarantee a linear growth. Even when it's biopsied at a timed interval you can't get a full picture of the cancer (invasive pattern etc) evolution trajectory. In some cases low grade tumours will be put on surveilance without radical treatment.

Diagnosis is complex too, you don't want the test to have low specificity. False positive is sometimes tolerated.
dumb1224
·9개월 전·discuss
Cellular level computational simulation existed a very long time and it's more impressive by the day because of large collections of experimental datasets available.

However to infer or predict celular acitivities you need a ton of domain knowledge and experties about particular cell types, biological processes and specific environments. Typically the successful ones are human curated and validated (e.g large interaction networks based on literature).

In cancer it's even more unpredictable because of the lack of good (experimental) models, in-vivo or in-vitro, representing what actually happens the clinically and biologically underneath. Given the single cell resolution, its uncertainty will also amplify because of how heterogeneous inter- and intra- tumours are.

Having said that, a foundation model is definitely the future for futher development. But with all of these things, the bigger the model, the harder the validation process.