Schizophrenia is basically symptoms of permeability of the blood brain barrier. Whole proteins pass through and mess things up. Similar to automimmune disease. Why else are those diseases on the list the only ones increasing in pravalence, and all others are decreasing (infectious, cancerous, viral, etc.). ASD is neuroprotective and tightens those cell junctions, with behavioral drawbacks. All these things are interrelated, the issue is they can be caused by 100k different contributing factors and susceptibilities.
The penjulum of "things startups are wrong about" and/or "you succeed despite this rather than because of it" open plan offices will shift back the other way in the next decade to "deep work" and "closed door productivity". Joel Spolsky & co are just two decades ahead.
I went through and activated Google Authenticator 2FA for everything. I am at about 45% of all accounts now. If you want to send feedback to Namecheap: [email protected].
Senior individual sales, full-time, in person, 2000+ person company.
[07:30]: Wake up naturally. Shower, shave, get dressed.
[08:15]: Walk 5-minutes with wife to work for breakfast.
[08:30]: Standup over breakfast with team, very boring.
[09:00]: Start working on new business outreach. Phone meetings and remote demos all morning in succession in large open space full of around 40 desks. I like the energy of the environment. I occasionally book a room if I want some space to work but mostly like the intensity.
[12:00]: Catered company lunch with buddies and/or wife
[12:30]: More work, same as before except more existing deal outreach and internal meetings in afternoon. Mostly go to a breakout space to get things done, peak energy during this time. This part is the most fun generally.
[17:30]: Walk 5 minutes home with wife. Sometimes take the long way.
[18:00]: Start and eat dinner, go for a walk again or to the gym.
[20:00]: Work on side project for 1-2 hours if time allows.
[21:30]: Read nonfiction with wife for an hour or two before bed.
[23:00]: Head to bed and hang out chatting before dozing off.
I do this everyday and would not change a thing with the exception of removing all formal training and most internal meetings and adding kids. Same as when I had a company except the part about nonfiction, side projects and standups was just grinding away instead.
Socialization is for pets. I just ran around the forest and played Runescape for my single digit formative years. I did not learn to read until I was 11. To call my childhood homeschooling would be offensive (to me), school is the whole thing I was trying to avoid. I was home though. I played sports and chess with other people my age and older. I missed nothing but the cynicical, pluralistic burnout one gets attending school. And as an adult, I would not say I am missing anything social skills wise, other than that pathological desire to be normal school people have. Mimesis begets external validation begets emptiness.
I have done a great deal of armchair research in this area. It seems like if we can figure out a way to get the salt out of the cells, Salicornia protein would be an excellent, sustainable way to offer humans a plant based protein for which the inputs are literally sun and sea water and the output is a high quality vegan protein source that can be grown in the dessert. Getting the salt out of the cells was above my head biochem wise but I hope this goes the Tesla route of disruption, starting as a garnish on fancy hipster salads and ending up the standard in staple meal cooking greens. The biggest advantage is the lack of reliable on fresh water and ability to grow on saline land. If we can create the demand the business case for a business whose main inputs are sunlight and seawater is pretty strong.
Talk to customers. Who is the customer? Talk to them. Ask them how they do it now. Ask them to describe how it would ideally work. Ask them how much they would be willing to pay, and tell them your question is not to bottom line them but to figure out how they perceive what it would be worth. Ask them if they are willing to commit to pay that if you are able to meet A, B and C minimum viable functionality. Ask them to put it in writing.
I think LinkedIn is good for information gathering, but you should ideally cold email people with an ask for 10 minutes on the phone and then schedule as many phone calls a day as you can. These are called discovery calls. Your goal is to discover what the priorities and needs of the business are in the area you intend to tackle to figure out if there is even a business there in the first place.
If those calls go well and a few people are willing to put in writing an intention to purchase it if you are able to deliver, build the A, B and C functionality as fast as possible and then call them back and ask them to pay for it. Assume half of those never actually intended to pay for it. Assume the other half will email you constantly complaining that you are missing D, E and F. Call a bunch of new people who you think might be customers and ask how critical D, E and F are.
If they are critical, ask those new customers if they would commit in writing to purchase such a solution. A few more will be willing to than before if you are on to something. Build D, E and F to appease the initial customers (they will be happy) and close the next customers. Carefully reflect on what the potential market is now that you have ABCDEF. Try as much as possible to sell that to new customers until you have a critical mass. At that point you should be nearing product/market fit.
Then ask yourself what you are best at? Try to use customer money to fund hiring everything that is not that thing. Continue to repeat this process through increasingly large and complex markets and layers of abstration below you in the organization heirarchy. Sorry I only have time to write but not to edit, hope this helps.
Include a line about using their likelness for marketing purposes in the terms of service and contract and agree to waive it for anyone not comfortable with the concept.
All my friends, immediate and extended family communicate over Signal. <50% use Facebook, login once a week and are horrified by the posts, log back out. We are probably not typical users of technology, but Signal is our core communication tool now.
It is insane, and yes you can "expense" mortgage interest against your taxes, and in the case of a rental, a portion of everything else too. Incentivizes owning houses.
Celiac here. I went through a not nearly as bad although still 18 month long painful regression, diagnoses and recovery period before getting to my current better than ever state (thanks to diagnoses and fixing my diet). My brother and I wrote a learning algorithm in Go that allows you to log your food and how it made you feel, and then it evaluates that against all of the other things you have eaten and changes the score for that food. After a month or two of data you start to see compelling patterns, and it allows you to isolate single ingredients through continued trial and error. If something results in 10 bad experiences and no good ones, it is probably a trigger food and should be eliminated. On the opposite end, you can conclusively rule out foods by trialing them with a bunch of other ingredients and seeing if they cause problems.
I built it because three people I know went through processes similar to the one you describe and they found the trying foods process very hard to track in a way that made is easy to determine which foods were a problem. I never took it further but the Go app is deployable and I think there is a great service to be built I have just been busy with my day job. I think that if this job goes well I will have enough money to work on this mission full time and at that point I will revisit this project and try to make it more functional and integrate with other medical and health devices and APIs for easier logging and better correlations (ie. eat a food, that increases heart rate 10-20bpm indicating autoimmune response of some kind, that is automatically tracked and the food is scored lower).
I signed up on the website, first name starts with R and time around 21:20, feel free to email me and we can chat.
It would be easier to make people give up most of their rights and freedoms than it would be to make them stop eating bad food that will make them an expensive burden to the healthcare system. The only solution is to regulate and tax the way cigarettes are. All that Pepsi goes to fund all that diabetes and heart disease. Everyone, including the highly competent managers and researchers at Pepsi, knows it is bad for you. That does not mean no one should work for Philip Morris - it just means there are probably more virtuous ways to spend your time. Ultimately, society will give the people what they want, so we should tax the bad wants.
This makes sense. In business, it pays to be objective. But this effect is a coping mechanism that spans areas of life well beyond business. Similar to how everyone considers themselves an above average driver - narcissism/inflated sense of self keeps people in the gene pool. It is not a long term strategy, though, so the longer you lie to yourself, the more life will find your real level for you. I think that you can actually go a long time with this reality distortion - and the same narcissism can be implicated as much in success as in failure.